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Study · Randomized controlled trial · n = 7 · 1986

6 results

Somatostatin and oxytocin infusion inhibits the rise of plasma beta-endorphin, beta-lipotrophin and cortisol induced by insulin hypoglycaemia.

Petraglia F, Facchinetti F, D'Ambrogio G, Volpe A, Genazzani AR

Clinical endocrinology1 Jun 1986Cited by 23 (Europe PMC)

PMID2878746 (opens in a new tab)DOI10.1111/j.1365-2265.1986.tb01656.x (opens in a new tab)PepBankPUB-02878746
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy adults, oxytocin infusion did not significantly change basal plasma beta-endorphin.

    In plain wordsIn healthy adults, oxytocin infusion did not change resting beta-endorphin levels in blood.

    Peptide
    Oxytocin
    Outcome
    No significant changeBasal plasma beta-endorphin
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    0.4 micrograms/min · 120 minAs given in this study (human).

    Source sentences

    Summary
    Neither somatostatin nor oxytocin significantly modified basal plasma levels of beta-END, beta-LPH and cortisol.
    2 context sentences
    Summary · context
    For this purpose somatostatin (4.1 micrograms/min for 120 min or oxytocin (0.4 micrograms/min for 120 min) was infused into two different groups of seven healthy subjects; 30 min after the start of the infusion, placebo or insulin (0.1 IU/kg body weight, B.W.) was injected on two different days.
    Summary · context
    Plasma levels of beta-END, beta-LPH and cortisol were measured by radioimmunoassay.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy adults, oxytocin infusion did not significantly change basal plasma beta-lipotrophin.

    In plain wordsIn healthy adults, oxytocin infusion did not change resting beta-lipotrophin levels in blood.

    Peptide
    Oxytocin
    Outcome
    No significant changeBasal plasma beta-lipotrophin
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    0.4 micrograms/min · 120 minAs given in this study (human).

    Source sentences

    Summary
    Neither somatostatin nor oxytocin significantly modified basal plasma levels of beta-END, beta-LPH and cortisol.
    2 context sentences
    Summary · context
    For this purpose somatostatin (4.1 micrograms/min for 120 min or oxytocin (0.4 micrograms/min for 120 min) was infused into two different groups of seven healthy subjects; 30 min after the start of the infusion, placebo or insulin (0.1 IU/kg body weight, B.W.) was injected on two different days.
    Summary · context
    Plasma levels of beta-END, beta-LPH and cortisol were measured by radioimmunoassay.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy adults, oxytocin infusion did not significantly change basal plasma cortisol.

    In plain wordsIn healthy adults, oxytocin infusion did not change resting cortisol levels in blood.

    Peptide
    Oxytocin
    Outcome
    No significant changeBasal plasma cortisol
    Study

    n = 7

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    0.4 micrograms/min · 120 minAs given in this study (human).

    Source sentences

    Summary
    Neither somatostatin nor oxytocin significantly modified basal plasma levels of beta-END, beta-LPH and cortisol.
    2 context sentences
    Summary · context
    For this purpose somatostatin (4.1 micrograms/min for 120 min or oxytocin (0.4 micrograms/min for 120 min) was infused into two different groups of seven healthy subjects; 30 min after the start of the infusion, placebo or insulin (0.1 IU/kg body weight, B.W.) was injected on two different days.
    Summary · context
    Plasma levels of beta-END, beta-LPH and cortisol were measured by radioimmunoassay.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy adults, oxytocin infusion blunted the rise of plasma beta-endorphin during insulin-induced hypoglycaemia (P less than 0.01).

    In plain wordsIn healthy adults, oxytocin infusion reduced the beta-endorphin rise caused by low blood sugar, compared with saline infusion.

    Peptide
    Oxytocin
    Outcome
    DecreaseInsulin hypoglycaemia-induced rise of beta-endorphin
    Study

    n = 7

    Comparator
    Insulin tolerance test during saline infusion
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    0.4 micrograms/min · 120 minAs given in this study (human).

    Source sentences

    Summary
    However these treatments blunted the rise of the three hormones seen at 45 and 60 min during insulin-induced hypoglycaemia (P less than 0.01).
    3 context sentences
    Summary · context
    In a third experimental step, an insulin tolerance test was performed during saline infusion to evaluate stress-related effects on the different hormonal secretions under basal conditions.
    Summary · context
    For this purpose somatostatin (4.1 micrograms/min for 120 min or oxytocin (0.4 micrograms/min for 120 min) was infused into two different groups of seven healthy subjects; 30 min after the start of the infusion, placebo or insulin (0.1 IU/kg body weight, B.W.) was injected on two different days.
    Summary · context
    Plasma levels of beta-END, beta-LPH and cortisol were measured by radioimmunoassay.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In healthy adults, oxytocin infusion blunted the rise of plasma beta-lipotrophin during insulin-induced hypoglycaemia (P less than 0.01).

    In plain wordsIn healthy adults, oxytocin infusion reduced the beta-lipotrophin rise caused by low blood sugar, compared with saline infusion.

    Peptide
    Oxytocin
    Outcome
    DecreaseInsulin hypoglycaemia-induced rise of beta-lipotrophin
    Study

    n = 7

    Comparator
    Insulin tolerance test during saline infusion
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    0.4 micrograms/min · 120 minAs given in this study (human).

    Source sentences

    Summary
    However these treatments blunted the rise of the three hormones seen at 45 and 60 min during insulin-induced hypoglycaemia (P less than 0.01).
    3 context sentences
    Summary · context
    In a third experimental step, an insulin tolerance test was performed during saline infusion to evaluate stress-related effects on the different hormonal secretions under basal conditions.
    Summary · context
    For this purpose somatostatin (4.1 micrograms/min for 120 min or oxytocin (0.4 micrograms/min for 120 min) was infused into two different groups of seven healthy subjects; 30 min after the start of the infusion, placebo or insulin (0.1 IU/kg body weight, B.W.) was injected on two different days.
    Summary · context
    Plasma levels of beta-END, beta-LPH and cortisol were measured by radioimmunoassay.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In healthy adults, oxytocin infusion blunted the rise of plasma cortisol during insulin-induced hypoglycaemia (P less than 0.01).

    In plain wordsIn healthy adults, oxytocin infusion reduced the cortisol rise caused by low blood sugar, compared with saline infusion.

    Peptide
    Oxytocin
    Outcome
    DecreaseInsulin hypoglycaemia-induced rise of cortisol
    Study

    n = 7

    Comparator
    Insulin tolerance test during saline infusion
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    0.4 micrograms/min · 120 minAs given in this study (human).

    Source sentences

    Summary
    However these treatments blunted the rise of the three hormones seen at 45 and 60 min during insulin-induced hypoglycaemia (P less than 0.01).
    3 context sentences
    Summary · context
    In a third experimental step, an insulin tolerance test was performed during saline infusion to evaluate stress-related effects on the different hormonal secretions under basal conditions.
    Summary · context
    For this purpose somatostatin (4.1 micrograms/min for 120 min or oxytocin (0.4 micrograms/min for 120 min) was infused into two different groups of seven healthy subjects; 30 min after the start of the infusion, placebo or insulin (0.1 IU/kg body weight, B.W.) was injected on two different days.
    Summary · context
    Plasma levels of beta-END, beta-LPH and cortisol were measured by radioimmunoassay.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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