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Study · Animal study (in vivo) · rat · 1986

2 results

Biphasic effects of MIF-1 and Tyr-MIF-1 on apomorphine-induced stereotypy in rats.

Hara C, Kastin AJ

Pharmacology, biochemistry, and behavior1 Oct 1986Cited by 18 (Europe PMC)

PMID2878442 (opens in a new tab)DOI10.1016/0091-3057(86)90383-7 (opens in a new tab)PepBankPUB-02878442
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MIF‑1 increased stereotypic behavior induced by apomorphine at 0.5 and 1.0 mg/kg.

    In plain wordsIn rats, MIF‑1 increased repetitive behavior induced by apomorphine at 0.5 and 1.0 mg/kg.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseStereotypy with lower apomorphine doses
    Study

    Ratn: not reported in source

    Apomorphine-induced stereotypy
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    0.2, 0.5, 1.0 and 5.0 mg/kg · SCAs given in this study (Rat).

    Source sentences

    Summary
    MIF-1 increased the stereotypic behavior induced by 0.5 and 1.0 mg/kg of APO, but decreased the stereotypic behavior induced by 2.0 mg/kg of APO.
    1 context sentence
    Summary · context
    The effects of several doses of MIF-1 and Tyr-MIF-1 (0.2, 0.5, 1.0 and 5.0 mg/kg, SC) on the stereotypic behavior induced by various doses (0.08, 0.2, 0.5, 1.0 and 2.0 mg/kg, SC) of apomorphine (APO) were tested in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MIF‑1 decreased stereotypic behavior induced by apomorphine at 2.0 mg/kg.

    In plain wordsIn rats, MIF‑1 reduced repetitive behavior induced by apomorphine at 2.0 mg/kg.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseStereotypy with higher apomorphine dose
    Study

    Ratn: not reported in source

    Apomorphine-induced stereotypy
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    0.2, 0.5, 1.0 and 5.0 mg/kg · SCAs given in this study (Rat).

    Source sentences

    Summary
    MIF-1 increased the stereotypic behavior induced by 0.5 and 1.0 mg/kg of APO, but decreased the stereotypic behavior induced by 2.0 mg/kg of APO.
    1 context sentence
    Summary · context
    The effects of several doses of MIF-1 and Tyr-MIF-1 (0.2, 0.5, 1.0 and 5.0 mg/kg, SC) on the stereotypic behavior induced by various doses (0.08, 0.2, 0.5, 1.0 and 2.0 mg/kg, SC) of apomorphine (APO) were tested in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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