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Study · Animal study (in vivo) · mouse · 1986

4 results

Prolyl-leucyl-glycinamide (PLG): inhibition of offensive aggression in mice.

Kavaliers M, Hirst M

Life sciences1 Nov 1986Cited by 4 (Europe PMC)

PMID2877382 (opens in a new tab)DOI10.1016/0024-3205(86)90091-3 (opens in a new tab)PepBankPUB-02877382
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male dominant resident mice, PLG reduced the incidence of offensive aggression in a dose-dependent manner.

    In plain wordsIn mice, MIF‑1 reduced how often offensive aggression occurred, with a dose-dependent effect.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseIncidence of offensive aggression
    Study

    Mousen: not reported in source

    Male dominant resident mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.01-10 mg/KgAs given in this study (Mouse).

    Source sentences

    Summary
    PLG (0.01-10 mg/Kg) reduced, in a dose-dependent manner, the incidence and intensity of offensive aggression in dominant resident mice.
    1 context sentence
    Summary · context
    The effects on offensive aggression of the endogenous peptide-leucyl-glycinamide (PLG, MIF-1) and the exogenous opiate antagonist, naloxone, were examined in male mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male dominant resident mice, PLG reduced the intensity of offensive aggression in a dose-dependent manner.

    In plain wordsIn mice, MIF‑1 reduced the intensity of offensive aggression, with a dose-dependent effect.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseIntensity of offensive aggression
    Study

    Mousen: not reported in source

    Male dominant resident mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.01-10 mg/KgAs given in this study (Mouse).

    Source sentences

    Summary
    PLG (0.01-10 mg/Kg) reduced, in a dose-dependent manner, the incidence and intensity of offensive aggression in dominant resident mice.
    1 context sentence
    Summary · context
    The effects on offensive aggression of the endogenous peptide-leucyl-glycinamide (PLG, MIF-1) and the exogenous opiate antagonist, naloxone, were examined in male mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male mice, PLG was more potent against offensive aggression than naloxone.

    In plain wordsIn mice, MIF‑1 was more potent against offensive aggression than naloxone.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseAnti-aggressive potency versus naloxone
    Study

    Mousen: not reported in source

    Male dominant resident mice
    Comparator
    Naloxone 1.0 mg/Kg
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.01-10 mg/KgAs given in this study (Mouse).

    Source sentences

    Summary
    PLG was more potent than naloxone (1.0 mg/Kg).
    1 context sentence
    Summary · context
    The effects on offensive aggression of the endogenous peptide-leucyl-glycinamide (PLG, MIF-1) and the exogenous opiate antagonist, naloxone, were examined in male mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In some dominant resident mice, PLG completely eliminated offensive aggression towards intruder mice.

    In plain wordsIn some mice, MIF‑1 completely stopped offensive aggression towards intruder mice.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseComplete elimination of offensive aggression
    Study

    Mousen: not reported in source

    Male dominant resident mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.01-10 mg/KgAs given in this study (Mouse).

    Source sentences

    Summary
    In a number of cases, PLG completely eliminated the display of offensive aggression towards intruder mice.
    1 context sentence
    Summary · context
    The effects on offensive aggression of the endogenous peptide-leucyl-glycinamide (PLG, MIF-1) and the exogenous opiate antagonist, naloxone, were examined in male mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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