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Study · Animal study (in vivo) · rat · 1986

1 result

The role of metabolism in the action of prolyl-leucyl-glycinamide on the development of tolerance to the analgesic effect of morphine.

Bhargava HN

Neuropharmacology1 Jul 1986Cited by 9 (Europe PMC)

PMID2875417 (opens in a new tab)DOI10.1016/0028-3908(86)90089-4 (opens in a new tab)PepBankPUB-02875417
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male Sprague-Dawley rats, Pro-Leu-Gly-NH2 inhibited the development of tolerance to morphine analgesia.

    In plain wordsIn rats, Pro-Leu-Gly-NH2 reduced the development of tolerance to morphine's pain-relieving effect.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseDevelopment of morphine analgesic tolerance
    Study

    Ratn: not reported in source

    Male Sprague-Dawley rats with morphine pellet-induced tolerance
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    10 mumol/kg per day · SubcutaneousAs given in this study (Rat).

    Source sentences

    Summary
    Subcutaneous injections of Pro-Leu-Gly-NH2, Pro-Leu-OH or Leu-Gly-NH2 (10 mumol/kg per day), prior to and during the implantation of pellets, inhibited the development of tolerance to morphine.
    2 context sentences
    Summary · context
    In order to understand the mechanism by which this effect is produced, the effects of the possible metabolites of Pro-Leu-Gly-NH2 on the development of tolerance to the analgesic effects of morphine were determined in male Sprague-Dawley rats.
    Summary · context
    Rats were made tolerant to morphine by the subcutaneous implantation of four pellets of morphine over a 3-day period.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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