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Study · Animal study (in vivo) · rat · 1986

2 results

Acute administration of MIF-1 or Tyr-MIF-1 inhibits haloperidol-induced catalepsy in rats.

Hara C, Kastin AJ

Pharmacology, biochemistry, and behavior1 Jun 1986Cited by 17 (Europe PMC)

PMID2874569 (opens in a new tab)DOI10.1016/0091-3057(86)90521-6 (opens in a new tab)PepBankPUB-02874569
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, optimal effects on haloperidol-induced catalepsy occurred with MIF‑1 at 1.0 mg/kg SC 30 min before testing and haloperidol an hour before testing.

    In plain wordsIn rats, MIF‑1 had its optimal effect on haloperidol-induced catalepsy at 1.0 mg/kg, given 30 min before testing.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseCatalepsy under optimized pretreatment conditions
    Study

    Ratn: not reported in source

    Haloperidol-induced catalepsy
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    1.0 mg/kg · SCAs given in this study (Rat).

    Measurements

    MIF-1 dose
    1 mg/kg
    optimal effect

    Source sentences

    Summary
    It was found that the optimal effect was achieved with a dose of 1.0 mg/kg haloperidol injected SC an hour before testing for catalepsy and 1.0 mg/kg MIF-1 injected SC 30 min before testing.
    1 context sentence
    Summary · context
    The effects of MIF-1 (Pro-Leu-Gly-NH2) and Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) on haloperidol-induced catalepsy were studied in order to examine the influences of both peptides on central dopaminergic function.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MIF‑1 inhibited haloperidol-induced catalepsy with an inverted U-shaped dose response and maximal effect at 1.0 mg/kg.

    In plain wordsIn rats, MIF‑1 reduced haloperidol-induced catalepsy, with its greatest effect at 1.0 mg/kg.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseCatalepsy dose-response
    Study

    Ratn: not reported in source

    Haloperidol-induced catalepsy
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Dose at maximal effect
    1 mg/kg
    MIF-1

    Source sentences

    Summary
    Catalepsy was inhibited in an inverted U-shape dose-response relationship with the maximal effect of each peptide occurring at 1.0 mg/kg.
    2 context sentences
    Summary · context
    In the second experiment, Tyr-MIF-1 as well as MIF-1 were injected as single injections at four doses.
    Summary · context
    The effects of MIF-1 (Pro-Leu-Gly-NH2) and Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) on haloperidol-induced catalepsy were studied in order to examine the influences of both peptides on central dopaminergic function.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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