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Study · Non-randomized trial · 1986

5 results

The interaction of growth hormone releasing hormone with other hypothalamic hormones on the release of anterior pituitary hormones.

Looij BJ Jr, Nieuwenhuijzen Kruseman AC, Mudde AH, Frölich M, Piaditis GP, Hodgkinson SC, McLean C, Grossman A, Coy DH, Rees LH

Clinical endocrinology1 Feb 1986Cited by 24 (Europe PMC)

PMID2871949 (opens in a new tab)DOI10.1111/j.1365-2265.1986.tb00757.x (opens in a new tab)PepBankPUB-02871949
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    Each intravenous bolus of GHRH(1-29)NH2 caused a rapid rise in plasma GH.

    In plain wordsEach dose of the GHRH peptide quickly raised growth hormone in the blood.

    Peptide
    Sermorelin
    Outcome
    IncreasePlasma GH increment after GHRH(1-29)NH2
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    Each infusion of GHRH(1-29)NH2 resulted in a rapid increment of the plasma GH value.
  2. 02HumanNon-randomized trialEfficacy outcome

    GHRH(1-29)NH2 caused a small transient rise in plasma PRL but no change in the integrated PRL response.

    In plain wordsThe GHRH peptide caused a small short rise in prolactin, but the total prolactin response did not change.

    Peptide
    Sermorelin
    Outcome
    MixedPlasma PRL response to GHRH(1-29)NH2
    Study

    n: not reported in source

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    Infusion of GHRH(1-29)NH2 also caused a small and transient rise in plasma PRL, but no change in the integrated PRL response.
  3. 03HumanNon-randomized trialEfficacy outcome

    GHRH(1-29)NH2 combined with LHRH plus TRH produced larger peak and integrated plasma TSH increments than LHRH plus TRH alone.

    In plain wordsAdding the GHRH peptide to two other releasing hormones gave a bigger thyroid-stimulating hormone rise than the two hormones alone.

    Peptide
    Sermorelin
    Outcome
    IncreaseTSH response to LHRH plus TRH with or without GHRH(1-29)NH2
    Study

    n: not reported in source

    Comparator
    LHRH plus TRH alone
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    The combination of GHRH(1-29)NH2 with LHRH plus TRH caused a larger increment of peak and integrated plasma TSH levels than LHRH plus TRH alone.
  4. 04HumanNon-randomized trialEfficacy outcome

    GHRH(1-29)NH2 did not affect the release of other anterior pituitary hormones after infusion with oCRH or LHRH plus TRH.

    In plain wordsThe GHRH peptide did not change the release of other pituitary hormones after the other releasing hormones.

    Peptide
    Sermorelin
    Outcome
    No significant changeOther anterior pituitary hormone release with oCRH or LHRH plus TRH
    Study

    n: not reported in source

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    GHRH(1-29)NH2 did not affect the release of other anterior pituitary hormones after infusion with oCRH or LHRH plus TRH.
  5. 05HumanNon-randomized trialEfficacy outcome

    GHRH(1-29)NH2, like GHRH(1-40), combined with TRH produced larger peak and integrated plasma TSH increments than TRH alone.

    In plain wordsAdding the GHRH peptide to TRH gave a bigger thyroid-stimulating hormone rise than TRH alone.

    Peptide
    Sermorelin
    Outcome
    IncreaseTSH response to TRH with or without GHRH preparations
    Study

    n: not reported in source

    Comparator
    TRH alone
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    In this study the combination of TRH with both GHRH preparations also caused a larger increment of the peak and integrated plasma TSH levels than TRH alone.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

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