Vasoactive intestinal peptide increases tyrosine hydroxylase activity in normal and neoplastic rat chromaffin cell cultures.

Tischler AS, Perlman RL, Costopoulos D, Horwitz J

Neuroscience letters1 Oct 1985Cited by 26 (Europe PMC)

PMID2867499DOI10.1016/0304-3940(85)90415-xPepBankPUB-02867499

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In cultured normal adult rat chromaffin cells, VIP at 10 microM increased tyrosine hydroxylase activity about 3-fold.
In plain wordsIn rat adrenal cells in culture, a high VIP concentration raised the activity of tyrosine hydroxylase about 3-fold.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseTyrosine hydroxylase activity in normal chromaffin cells
Study
ratn: not reported in source
Cultured dispersed normal adult rat chromaffin cells
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
10 microMAs given in this study (rat).
Measurements
TH activity increase
≈ 3 fold
normal chromaffin cells, VIP 10 microM
Source sentences
Summary
High concentrations of VIP (10 microM) produce about 3-fold increases in TH activity in both cell types.
1 context sentence(design, population, supporting numbers)
Summary · context
Vasoactive intestinal peptide (VIP) acutely increases tyrosine hydroxylase (TH) activity in cultures of dispersed normal adult rat chromaffin cells and of PC12 rat pheochromocytoma cells.
Report a problemFND-0286749901
02LabIn vitro (cells)Activity measurement
In PC12 rat pheochromocytoma cells, VIP at 10 microM increased tyrosine hydroxylase activity about 3-fold.
In plain wordsIn rat tumour cells in culture, a high VIP concentration raised the activity of tyrosine hydroxylase about 3-fold.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseTyrosine hydroxylase activity in PC12 cells
Study
ratn: not reported in source
PC12 rat pheochromocytoma cells
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
10 microMAs given in this study (rat).
Measurements
TH activity increase
≈ 3 fold
PC12 cells, VIP 10 microM
Source sentences
Summary
High concentrations of VIP (10 microM) produce about 3-fold increases in TH activity in both cell types.
1 context sentence(design, population, supporting numbers)
Summary · context
Vasoactive intestinal peptide (VIP) acutely increases tyrosine hydroxylase (TH) activity in cultures of dispersed normal adult rat chromaffin cells and of PC12 rat pheochromocytoma cells.
Report a problemFND-0286749902
03LabIn vitro (cells)Activity measurement
In PC12 rat pheochromocytoma cells, VIP increased the content of cyclic AMP.
In plain wordsIn rat tumour cells in culture, VIP raised the level of the signalling molecule cAMP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasecAMP content in PC12 cells
Study
ratn: not reported in source
PC12 rat pheochromocytoma cells
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
VIP also increases the content of cyclic adenosine 3':5'-monophosphate (cAMP) in PC12 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Vasoactive intestinal peptide (VIP) acutely increases tyrosine hydroxylase (TH) activity in cultures of dispersed normal adult rat chromaffin cells and of PC12 rat pheochromocytoma cells.
Report a problemFND-0286749903

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.