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Study · Animal study (in vivo) · rat · 1985

3 results

Effect of chronic treatment with morphine on the binding of 3H-N-n-propylnorapomorphine to striatal membranes of rats: influence of prolyl-leucyl-glycinamide.

Das S, Bhargava HN

Pharmacology1 Jan 1985Cited by 7 (Europe PMC)

PMID2866551 (opens in a new tab)DOI10.1159/000138128 (opens in a new tab)PepBankPUB-02866551
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, MIF antagonized the morphine-induced decreases in the apparent dissociation constant of striatal 3H-NPA binding.

    In plain wordsIn rats, MIF‑1 opposed morphine's reduction of the apparent dissociation constant for striatal dopamine agonist binding.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseApparent dissociation constant during morphine treatment
    Study

    Ratn: not reported in source

    Sprague-Dawley rats, striatal dopamine agonist binding after in vivo treatment
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2 mg/kgAs given in this study (Rat).

    Source sentences

    Summary
    MIF antagonized the decreases in Kd values induced by the administration of morphine.
    2 context sentences
    Summary · context
    The effect of prolyl-leucyl-glycinamide (MIF; 2 mg/kg), which has been shown to inhibit the development of tolerance to and dependence on morphine, on the changes in the binding of 3H-NPA induced by the implantation of morphine pellets was also determined.
    Summary · context
    The effect of chronic administration of morphine to Sprague-Dawley rats on the binding of dopamine receptor agonist, 3H-N-n-propylnorapomorphine (3H-NPA) to striatal membranes was determined.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, chronic MIF alone did not affect the total number of striatal 3H-NPA binding sites.

    In plain wordsIn rats, chronic MIF‑1 alone did not change the number of striatal dopamine agonist binding sites.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeTotal binding sites with MIF alone
    Study

    Ratn: not reported in source

    Sprague-Dawley rats, striatal dopamine agonist binding after in vivo treatment
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, when administered chronically by itself, MIF had no effect on either the Bmax or Kd values of 3H-NPA.
    1 context sentence
    Summary · context
    The effect of chronic administration of morphine to Sprague-Dawley rats on the binding of dopamine receptor agonist, 3H-N-n-propylnorapomorphine (3H-NPA) to striatal membranes was determined.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, chronic MIF alone did not affect the apparent dissociation constant of striatal 3H-NPA binding.

    In plain wordsIn rats, chronic MIF‑1 alone did not change the apparent dissociation constant for striatal dopamine agonist binding.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeApparent dissociation constant with MIF alone
    Study

    Ratn: not reported in source

    Sprague-Dawley rats, striatal dopamine agonist binding after in vivo treatment
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, when administered chronically by itself, MIF had no effect on either the Bmax or Kd values of 3H-NPA.
    1 context sentence
    Summary · context
    The effect of chronic administration of morphine to Sprague-Dawley rats on the binding of dopamine receptor agonist, 3H-N-n-propylnorapomorphine (3H-NPA) to striatal membranes was determined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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