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Study · Animal study (in vivo) · rhesus monkey · 1985

7 results

Identification of major urinary metabolites of nafarelin acetate, a potent agonist of luteinizing hormone-releasing hormone, in the rhesus monkey.

Chan RL, Chaplin MD

Drug metabolism and disposition: the biological fate of chemicals1 Sept 1985Cited by 4 (Europe PMC)

PMID2865104 (opens in a new tab)DOI10.1016/s0090-9556(25)08251-0 (opens in a new tab)PepBankPUB-02865104
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus monkeys, about 80% of nafarelin-associated radioactivity was eliminated in urine after a single dose.

    In plain wordsIn rhesus monkeys, about 80% of nafarelin-associated radioactivity was eliminated in urine.

    Peptide
    Nafarelin
    Outcome
    Not applicableUrinary elimination
    Study

    rhesus monkeyn: not reported in source

    female rhesus monkeys
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    After a single iv administration of nafarelin acetate (with 14C label at C-3 of 3-(2-naphthyl)-D-Ala) to female rhesus monkeys, about 80% of the radioactivity was eliminated in urine.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus monkeys, urinary nafarelin metabolites included the 5-10-hexapeptide amide, 6-10-pentapeptide amide, 5-7-tripeptide, and 6-7-dipeptide.

    In plain wordsIn rhesus monkeys, four major urinary nafarelin metabolites were short peptide fragments.

    Peptide
    Nafarelin
    Outcome
    Not applicableUrinary peptide metabolites
    Study

    rhesus monkeyn: not reported in source

    female rhesus monkeys
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    Four of these metabolites, identified by amino acid analysis, were short peptides: the 5-10-hexapeptide amide, the 6-10-pentapeptide amide, the 5-7-tripeptide, and the 6-7-dipeptide.
    2 context sentences
    Summary · context
    Five major radioactive urinary metabolites were isolated and purified by reversed phase HPLC.
    Summary · context
    After a single iv administration of nafarelin acetate (with 14C label at C-3 of 3-(2-naphthyl)-D-Ala) to female rhesus monkeys, about 80% of the radioactivity was eliminated in urine.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus monkeys, 2-naphthylacetic acid accounted for about 15% of administered nafarelin-associated radioactivity.

    In plain wordsIn rhesus monkeys, 2-naphthylacetic acid accounted for about 15% of administered nafarelin-associated radioactivity.

    Peptide
    Nafarelin
    Outcome
    Not applicable2-naphthylacetic acid metabolite
    Study

    rhesus monkeyn: not reported in source

    female rhesus monkeys
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    The fifth metabolite, which accounted for about 15% of the radioactivity administered, was shown by NMR and mass spectrometry to be 2-naphthylacetic acid.
    1 context sentence
    Summary · context
    After a single iv administration of nafarelin acetate (with 14C label at C-3 of 3-(2-naphthyl)-D-Ala) to female rhesus monkeys, about 80% of the radioactivity was eliminated in urine.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus monkeys, five metabolites accounted for about 70% of urinary radioactivity and more than half of administered radioactivity.

    In plain wordsIn rhesus monkeys, five nafarelin metabolites accounted for about 70% of urinary radioactivity.

    Peptide
    Nafarelin
    Outcome
    Not applicableMajor metabolite recovery
    Study

    rhesus monkeyn: not reported in source

    female rhesus monkeys
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    These five metabolites together accounted for about 70% of the radioactivity recovered in the urine of rhesus monkeys, or more than half of the radioactivity in the administered dose.
    1 context sentence
    Summary · context
    After a single iv administration of nafarelin acetate (with 14C label at C-3 of 3-(2-naphthyl)-D-Ala) to female rhesus monkeys, about 80% of the radioactivity was eliminated in urine.
  5. 05AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus monkeys, a minor nafarelin metabolite coeluted with 3-(2-naphthyl)-D-Ala in two HPLC solvent systems.

    In plain wordsIn rhesus monkeys, a minor nafarelin metabolite coeluted with 3-(2-naphthyl)-D-Ala during laboratory analysis.

    Peptide
    Nafarelin
    Outcome
    Not applicableMinor urinary metabolite
    Study

    rhesus monkeyn: not reported in source

    female rhesus monkeys
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    A minor metabolite, which was not isolated, coeluted with 3-(2-naphthyl)-D-Ala in two solvent systems on HPLC.
    1 context sentence
    Summary · context
    After a single iv administration of nafarelin acetate (with 14C label at C-3 of 3-(2-naphthyl)-D-Ala) to female rhesus monkeys, about 80% of the radioactivity was eliminated in urine.
  6. 06AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus monkeys, small amounts of nafarelin remained in urine.

    In plain wordsIn rhesus monkeys, small amounts of unchanged nafarelin were present in urine.

    Peptide
    Nafarelin
    Outcome
    Not applicableUnchanged urinary nafarelin
    Study

    rhesus monkeyn: not reported in source

    female rhesus monkeys
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    Nafarelin acetate was also present in small amounts.
    2 context sentences
    Summary · context
    Five major radioactive urinary metabolites were isolated and purified by reversed phase HPLC.
    Summary · context
    After a single iv administration of nafarelin acetate (with 14C label at C-3 of 3-(2-naphthyl)-D-Ala) to female rhesus monkeys, about 80% of the radioactivity was eliminated in urine.
  7. 07AnimalAnimal study (in vivo)Pharmacokinetics

    In rhesus monkeys, several nafarelin metabolites were also present in plasma.

    In plain wordsIn rhesus monkeys, several nafarelin metabolites were also present in plasma.

    Peptide
    Nafarelin
    Outcome
    Not applicablePlasma metabolites
    Study

    rhesus monkeyn: not reported in source

    female rhesus monkeys
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rhesus monkey).

    Source sentences

    Summary
    Several of these metabolites were also present in plasma of the rhesus monkey.
    1 context sentence
    Summary · context
    After a single iv administration of nafarelin acetate (with 14C label at C-3 of 3-(2-naphthyl)-D-Ala) to female rhesus monkeys, about 80% of the radioactivity was eliminated in urine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

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