The effects of MIF-I, beta-endorphin and alpha-MSH on d-amphetamine induced paradoxical behavioral thermoregulation: possible involvement of the dopaminergic system.

Yehuda S, Sheleff P

Peptides1 Mar 1985Cited by 6 (Europe PMC)

PMID2863810DOI10.1016/0196-9781(85)90038-5PepBankPUB-02863810

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Sprague Dawley rats, MIF‑1 induced hypermotility, as did the other tested peptides.
In plain wordsIn rats, MIF‑1 increased movement, as did the other tested peptides.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseHypermotility
Study
Ratn: not reported in source
Sprague Dawley rats in a thermoregulatory runway
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated · IPAs given in this study (Rat).
Source sentences
Summary
All peptides induced hypermotility, although no differentiated effects for the peptides on d-amphetamine induced paradoxical behavioral thermoregulation were found.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined thermoregulatory behavior of rats in a runway device that housed a heat source at one end and in which locomotion along the length of the runway could be observed.
Summary · context
Sprague Dawley rats were pretreated with IP injections of saline, beta-endorphin, MIF-1, or alpha-MSH, with a repeat injection after 30 min.
Summary · context
In a second experiment, d-amphetamine was administered as the repeat drug for all Ss.
Report a problemFND-0286381001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, MIF‑1 showed no differentiated effect from the other peptides on amphetamine-induced paradoxical behavioral thermoregulation.
In plain wordsIn rats, MIF‑1 did not differ from the other tested peptides in its effect on amphetamine-induced temperature-related behavior.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
No significant changeAmphetamine-induced paradoxical behavioral thermoregulation
Study
Ratn: not reported in source
Sprague Dawley rats in a thermoregulatory runway
Comparator
Other tested peptides
Outcome group
Body temperature · Nervous system and cognition
Studied dose
Dose not stated · IPAs given in this study (Rat).
Source sentences
Summary
All peptides induced hypermotility, although no differentiated effects for the peptides on d-amphetamine induced paradoxical behavioral thermoregulation were found.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined thermoregulatory behavior of rats in a runway device that housed a heat source at one end and in which locomotion along the length of the runway could be observed.
Summary · context
Sprague Dawley rats were pretreated with IP injections of saline, beta-endorphin, MIF-1, or alpha-MSH, with a repeat injection after 30 min.
Summary · context
In a second experiment, d-amphetamine was administered as the repeat drug for all Ss.
Report a problemFND-0286381002

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

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