Skip to content

Study · Animal study (in vivo) · mouse · 1985

2 results

Prolyl-leucyl-glycinamide reduces aggression and blocks defeat-induced opioid analgesia in mice.

Teskey GC, Kavaliers M

Peptides1 Mar 1985Cited by 27 (Europe PMC)

PMID2863808 (opens in a new tab)DOI10.1016/0196-9781(85)90034-8 (opens in a new tab)PepBankPUB-02863808
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male mice, MIF‑1 reduced the number of bites required to obtain defeat in subordinate mice.

    In plain wordsIn mice, MIF‑1 reduced the number of bites required to defeat subordinate mice.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseBites required for defeat
    Study

    Mousen: not reported in source

    Male mice during aggressive encounters
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both substances reduced the number of bites required to obtain defeat in subordinate mice during aggressive encounters as well as blocking the subsequent defeat-induced analgesia.
    1 context sentence
    Summary · context
    The effects of Prolyl-leucyl-glycinamide (PLG, MIF-1) and the exogenous opiate antagonist naloxone, on aggressive interactions and defeat-induced analgesia were examined in male mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male mice, MIF‑1 blocked subsequent defeat-induced analgesia.

    In plain wordsIn mice, MIF‑1 blocked the pain-reducing effect that followed defeat.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseDefeat-induced analgesia
    Study

    Mousen: not reported in source

    Male mice during aggressive encounters
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both substances reduced the number of bites required to obtain defeat in subordinate mice during aggressive encounters as well as blocking the subsequent defeat-induced analgesia.
    1 context sentence
    Summary · context
    The effects of Prolyl-leucyl-glycinamide (PLG, MIF-1) and the exogenous opiate antagonist naloxone, on aggressive interactions and defeat-induced analgesia were examined in male mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.