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Study · Not a test of the peptide alone · 1985

4 results

Characteristics of the translation of thymosin alpha 1 precursor mRNA by cell-free wheat germ system. Evidence for the acetylation of thymosin alpha 1 precursor.

Nogueira M, Freire M

The International journal of biochemistry1 Jan 1985Cited by 1 (Europe PMC)

PMID2861125 (opens in a new tab)DOI10.1016/0020-711x(85)90152-1 (opens in a new tab)PepBankPUB-02861125
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Mechanism

    In a wheat germ cell-free system, purified thymosin alpha‑1 precursor mRNA saturated protein synthesis at a lower concentration than total thymus mRNAs.

    In plain wordsIn lab tests, the purified mRNA for the thymosin alpha‑1 precursor reached full protein synthesis at a lower concentration than total thymus mRNAs.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableTranslation saturation of precursor mRNA
    Study

    n: not reported in source

    wheat germ cell-free translation system
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    At the optimal concentrations of Mg2+ and K+ to translate total thymus PolyA+-RNA, the purified thymosin alpha 1 precursor mRNA saturate the protein synthetic activity at lower concentration than the total thymus mRNAs.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Mechanism

    In a wheat germ cell-free system, spermidine increased the translation rate of the thymosin alpha‑1 precursor mRNA without improving the yield of full-length chains.

    In plain wordsIn lab tests, spermidine sped up translation of the thymosin alpha‑1 precursor mRNA but did not raise the yield of full-length chains.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseEffect of spermidine on precursor translation rate
    Study

    n: not reported in source

    wheat germ cell-free translation system
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The polyamine spermidine increases the translation rate of the messenger, which is modulated by magnesium, rather than improve the yield in full-length chains of thymosin alpha 1 precursor.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 03LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Mechanism

    In a wheat germ cell-free system, [3H]acetate was incorporated into the translation product, which is evidence for acetylation of the thymosin alpha‑1 precursor.

    In plain wordsIn lab tests, the thymosin alpha‑1 precursor made in a cell-free system took up labelled acetate, which suggests it is acetylated.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAcetylation of the thymosin alpha 1 precursor
    Study

    n: not reported in source

    wheat germ cell-free translation system
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The incorporation of [3H]acetate into the translation product of the messenger, shows an evidence for the acetylation of the thymosin alpha 1 precursor during its biosynthesis in vitro.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  4. 04LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Mechanism

    In a wheat germ cell-free system, the thymosin alpha‑1 precursor mRNA carried the cap modification at its 5' terminal end, as other eukaryotic mRNAs do.

    In plain wordsIn lab tests, the mRNA for the thymosin alpha‑1 precursor had the usual cap structure at its start, like other eukaryotic mRNAs.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableCap modification of the precursor mRNA
    Study

    n: not reported in source

    wheat germ cell-free translation system
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    As other eukariotic mRNAs, this messenger presents the "cap" modification at the 5'-end terminal position.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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