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Study · Animal study (in vivo) · rat · 1985

4 results

Dose-response characteristics of various peptides with growth hormone-releasing activity in the unanesthetized male rat.

McCormick GF, Millard WJ, Badger TM, Bowers CY, Martin JB

Endocrinology1 Jul 1985Cited by 22 (Europe PMC)

PMID2861083 (opens in a new tab)DOI10.1210/endo-117-1-97 (opens in a new tab)PepBankPUB-02861083
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In pretreated male rats, repeated administration of GHRP did not produce consistent GH responses, unlike rGRF and GRF44.

    In plain wordsIn rats, repeated GHRP doses gave uneven growth hormone responses, unlike two natural releasing factors.

    Peptide
    GHRP-6
    Outcome
    MixedConsistency of GH response to repeated GHRP
    Study

    ratn: not reported in source

    Adult male rats pretreated with diethyldithiocarbamate and antisomatostatin serum
    Comparator
    rGRF and GRF44
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast to either rGRF or GRF44, repeated administration of the same dose of GHRP did not produce consistent GH responses.
    1 context sentence
    Summary · context
    We describe a model to minimize endogenous hypothalamic interference by pretreating adult male rats with iv diethyldithiocarbamate and antisomatostatin serum.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In pretreated male rats, the first GHRP bolus produced a larger GH pulse than the second (P less than 0.01).

    In plain wordsIn rats, the first GHRP dose produced a bigger growth hormone pulse than the second dose.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH pulse after second versus first GHRP bolus
    Study

    ratn: not reported in source

    Adult male rats pretreated with diethyldithiocarbamate and antisomatostatin serum
    Comparator
    First GHRP bolus
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The first bolus of GHRP produced a larger GH pulse than the second (P less than 0.01)
    1 context sentence
    Summary · context
    We describe a model to minimize endogenous hypothalamic interference by pretreating adult male rats with iv diethyldithiocarbamate and antisomatostatin serum.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In pretreated male rats, GH responses to GHRP increased from injection 2 to injection 7.

    In plain wordsIn rats, growth hormone responses to repeated GHRP doses rose from the second to the seventh dose.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response across GHRP injections 2 to 7
    Study

    ratn: not reported in source

    Adult male rats pretreated with diethyldithiocarbamate and antisomatostatin serum
    Comparator
    Previous injection
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    followed by increasing GH responses from injections 2 to 7.
    1 context sentence
    Summary · context
    We describe a model to minimize endogenous hypothalamic interference by pretreating adult male rats with iv diethyldithiocarbamate and antisomatostatin serum.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In pretreated male rats, GHRP was about 2 log orders less potent than rGRF or GRF44 for GH release on a molar basis.

    In plain wordsIn rats, GHRP was far less potent than two natural releasing factors at releasing growth hormone.

    Peptide
    GHRP-6
    Outcome
    DecreaseMolar potency of GHRP for GH release
    Study

    ratn: not reported in source

    Adult male rats pretreated with diethyldithiocarbamate and antisomatostatin serum
    Comparator
    rGRF and GRF44
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP was about 2 log orders less potent than either rGRF or GRF44 on a molar basis.
    1 context sentence
    Summary · context
    We describe a model to minimize endogenous hypothalamic interference by pretreating adult male rats with iv diethyldithiocarbamate and antisomatostatin serum.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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