Skip to content

Study · In vitro (cells) · rat · 1985

3 results

Vasoactive intestinal peptide and PHI stimulate somatostatin release from rat cerebral cortical and diencephalic cells in dispersed cell culture.

Tapia-Arancibia L, Reichlin S

Brain research1 Jun 1985Cited by 31 (Europe PMC)

PMID2860951 (opens in a new tab)DOI10.1016/0006-8993(85)90416-0 (opens in a new tab)PepBankPUB-02860951
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In dispersed fetal rat cerebral cortical and diencephalic cells, VIP caused a dose-dependent release of somatostatin.

    In plain wordsIn rat brain cells in culture, VIP made the cells release more somatostatin as the dose went up.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseSomatostatin release from cortical and diencephalic cells
    Study

    ratn: not reported in source

    Dispersed fetal cerebral cortical and diencephalic cell culture
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    VIP elicited a dose-dependent release of somatostatin from both cortical and diencephalic cells, the lowest effective concentration being 6 X 10(-9) M.
    1 context sentence
    Summary · context
    dispersed fetal cerebral cortical and diencephalic cells grown in culture were exposed on day 10 or 11 of culture to various concentrations of VIP
  2. 02LabIn vitro (cells)Activity measurement

    In cultured fetal rat brain cells, VIP was more potent than PHI for somatostatin release; PHI was 0.06 to 0.1 times as potent as VIP.

    In plain wordsIn rat brain cells in culture, VIP caused somatostatin release at lower doses than PHI did.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicablePotency of PHI relative to VIP for somatostatin release
    Study

    ratn: not reported in source

    Dispersed fetal cerebral cortical and diencephalic cell culture
    Comparator
    PHI
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    PHI potency relative to VIP
    0.06 to 0.1 x VIP
    somatostatin release

    Source sentences

    Summary
    PHI also brought about release of somatostatin, but was between 0.06 and 0.1 times as potent as VIP.
    1 context sentence
    Summary · context
    dispersed fetal cerebral cortical and diencephalic cells grown in culture were exposed on day 10 or 11 of culture to various concentrations of VIP

Studies that did not test the peptide alone1

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  1. 03LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Activity measurement

    In cultured fetal rat brain cells, VIP and PHI together at 10(-7) M did not release more somatostatin than expected from an additive effect.

    In plain wordsIn rat brain cells in culture, VIP and PHI together did not add up to a larger somatostatin release.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeSomatostatin release with VIP plus PHI together
    Study

    ratn: not reported in source

    Dispersed fetal cerebral cortical and diencephalic cell culture
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition

    Source sentences

    Summary
    Placed together in a concentration of 10(-7) M, the two peptides did not have an additive effect.
    1 context sentence
    Summary · context
    dispersed fetal cerebral cortical and diencephalic cells grown in culture were exposed on day 10 or 11 of culture to various concentrations of VIP

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.