Vasoactive intestinal peptide receptors in rat spleen and brain: a shared communication network.

Wiedermann CJ, Sertl K, Zipser B, Hill JM, Pert CB

Peptides1 Jan 1988Cited by 13 (Europe PMC)

PMID2856804DOI10.1016/0196-9781(88)90218-5PepBankPUB-02856804

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In rat spleen, 125I-VIP bound to red pulp and most abundantly to the periarteriolar lymphoid sheath of the white pulp.
In plain wordsIn lab tests on rat spleen, labelled VIP attached mostly to the white pulp region that holds T cells.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicable125I-VIP binding sites in spleen
Study
ratn: not reported in source
Spleen and brain tissue sections
Outcome group
Receptor activity and mechanism · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
In spleen, specific binding of 125I-VIP occurs on red pulp and, most abundantly, on the periarteriolar lymphoid sheath (PALS) of white pulp.
1 context sentence(design, population, supporting numbers)
Summary · context
The binding sites for [125I]-vasoactive intestinal polypeptide (125I-VIP) in rat spleen and brain were localized using autoradiography.
Report a problemFND-0285680401
02LabEx vivo tissueMechanism
High affinity VIP receptors are present in rat spleen, with competition studies typical of VIP receptors elsewhere.
In plain wordsIn lab tests, rat spleen had high affinity VIP receptors like those found in other tissues.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableHigh affinity VIP receptors in spleen
Study
ratn: not reported in source
Spleen and brain tissue sections
Outcome group
Receptor activity and mechanism · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
High affinity VIP receptors are present in rat spleen, and competition studies reflect structure-activity relationship typical of VIP receptors elsewhere.
1 context sentence(design, population, supporting numbers)
Summary · context
The binding sites for [125I]-vasoactive intestinal polypeptide (125I-VIP) in rat spleen and brain were localized using autoradiography.
Report a problemFND-0285680402
03LabEx vivo tissueActivity measurement
In rat spleen sections, unlabelled VIP competed for 125I-VIP binding to both red pulp and white pulp.
In plain wordsIn lab tests on rat spleen, plain VIP competed with labelled VIP for binding in both red and white pulp.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableCompetition by unlabelled VIP for binding in spleen
Study
ratn: not reported in source
Spleen and brain tissue sections
Outcome group
Receptor activity and mechanism · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Unlabeled VIP competes for binding to both red pulp and white pulp
1 context sentence(design, population, supporting numbers)
Summary · context
The binding sites for [125I]-vasoactive intestinal polypeptide (125I-VIP) in rat spleen and brain were localized using autoradiography.
Report a problemFND-0285680403
04LabEx vivo tissueMechanism
In rat brain, VIP receptors are widely distributed, with the highest densities in sensory areas including the olfactory bulb, thalamic nuclei, cranial nuclei and area postrema.
In plain wordsIn lab tests on rat brain, VIP receptors were widespread, and most dense in sensory areas.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP receptor distribution in brain
Study
ratn: not reported in source
Spleen and brain tissue sections
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In the brain, VIP receptors are widely distributed with the highest densities occurring in "sensory" areas. Receptors are abundant in the olfactory bulb, thalamic nuclei, several cranial nuclei and the area postrema.
1 context sentence(design, population, supporting numbers)
Summary · context
The binding sites for [125I]-vasoactive intestinal polypeptide (125I-VIP) in rat spleen and brain were localized using autoradiography.
Report a problemFND-0285680404
05LabEx vivo tissueMechanism
High levels of 125I-VIP binding occurred on the inner walls of blood vessels in rat brain and spleen.
In plain wordsIn lab tests on rat tissue, labelled VIP attached strongly to the inner walls of blood vessels in brain and spleen.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicable125I-VIP binding on blood vessel walls
Study
ratn: not reported in source
Spleen and brain tissue sections
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
High levels of 125I-VIP binding occurred on inner walls of blood vessels of the brain and spleen.
1 context sentence(design, population, supporting numbers)
Summary · context
The binding sites for [125I]-vasoactive intestinal polypeptide (125I-VIP) in rat spleen and brain were localized using autoradiography.
Report a problemFND-0285680405
06LabEx vivo tissueActivity measurement
In rat spleen sections, secretin displaced 125I-VIP binding to the periarteriolar lymphoid sheath more potently than to red pulp.
In plain wordsIn lab tests on rat spleen, secretin pushed labelled VIP off the white pulp region more strongly than off the red pulp.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableSecretin displacement of 125I-VIP binding in spleen
Study
ratn: not reported in source
Spleen and brain tissue sections
Outcome group
Receptor activity and mechanism · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
whereas secretin displaces binding to PALS more potently than to red pulp.
1 context sentence(design, population, supporting numbers)
Summary · context
The binding sites for [125I]-vasoactive intestinal polypeptide (125I-VIP) in rat spleen and brain were localized using autoradiography.
Report a problemFND-0285680406

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

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