The effect of oxytocin infusion on adenohypophysial and adrenal cortical responses to insulin-induced hypoglycaemia.

Nussey SS, Page SR, Ang VT, Jenkins JS, White A

Clinical endocrinology1 Sept 1988Cited by 9 (Europe PMC)

PMID2855220DOI10.1111/j.1365-2265.1988.tb01223.xPepBankPUB-02855220

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialPharmacokinetics
In six lean men, mean plasma oxytocin increased from 1.9 pmol/l to 138 pmol/l during oxytocin infusion.
In plain wordsIn six lean men, oxytocin infusion raised blood oxytocin levels.
Peptide
Oxytocin
Outcome
IncreasePlasma oxytocin during oxytocin infusion
Study
n = 6
Outcome group
Pharmacokinetics · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Mean plasma oxytocin before infusion
1.9 pmol/l
oxytocin infusion
Mean plasma oxytocin during infusion
138 pmol/l
oxytocin infusion
Source sentences
Summary
During the oxytocin infusion mean plasma oxytocin increased from 1.9 pmol/l to 138 pmol/l.
1 context sentence(design, population, supporting numbers)
Summary · context
The responses of plasma adrenocorticotrophin (ACTH), cortisol, growth hormone (GH) and prolactin to insulin-induced hypoglycaemia were studied in six lean male subjects (age 22-29 years). Intravenous insulin tests were performed with and without oxytocin infusion.
Report a problemFND-0285522001
02HumanRandomized controlled trialEfficacy outcome
In six lean men, the blood sugar nadir during insulin-induced hypoglycaemia did not differ significantly between oxytocin and saline infusion.
In plain wordsIn six lean men, the lowest blood sugar after insulin was not different with oxytocin than with saline.
Peptide
Oxytocin
Outcome
No significant changeBlood sugar nadir during insulin-induced hypoglycaemia
Study
n = 6
Comparator
Saline infusion
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Blood sugar nadir occurred at the onset of symptoms (time S) with no significant differences between oxytocin and saline infusion.
1 context sentence(design, population, supporting numbers)
Summary · context
The responses of plasma adrenocorticotrophin (ACTH), cortisol, growth hormone (GH) and prolactin to insulin-induced hypoglycaemia were studied in six lean male subjects (age 22-29 years). Intravenous insulin tests were performed with and without oxytocin infusion.
Report a problemFND-0285522002
03HumanRandomized controlled trialEfficacy outcome
In six lean men, peak plasma ACTH after insulin-induced hypoglycaemia did not differ significantly between oxytocin and saline infusion.
In plain wordsIn six lean men, oxytocin infusion did not change the peak ACTH stress-hormone response to low blood sugar compared with saline.
Peptide
Oxytocin
Outcome
No significant changePeak plasma ACTH response to hypoglycaemia
Study
n = 6
Comparator
Saline infusion
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Peak plasma ACTH
266 ng/l
oxytocin
Peak plasma ACTH
281 ng/l
saline
Source sentences
Summary
There were no significant differences in plasma concentrations of ACTH, cortisol, GH or prolactin between saline and oxytocin infusion.
2 context sentences(design, population, supporting numbers)
Summary · context
Peak increase in plasma ACTH (oxytocin 266 +/- 54 ng/l; saline 281 +/- 43 ng/l, mean +/- SEM)
Summary · context
The responses of plasma adrenocorticotrophin (ACTH), cortisol, growth hormone (GH) and prolactin to insulin-induced hypoglycaemia were studied in six lean male subjects (age 22-29 years). Intravenous insulin tests were performed with and without oxytocin infusion.
Report a problemFND-0285522003
04HumanRandomized controlled trialEfficacy outcome
In six lean men, peak plasma cortisol after insulin-induced hypoglycaemia did not differ significantly between oxytocin and saline infusion.
In plain wordsIn six lean men, oxytocin infusion did not change the peak cortisol response to low blood sugar compared with saline.
Peptide
Oxytocin
Outcome
No significant changePeak plasma cortisol response to hypoglycaemia
Study
n = 6
Comparator
Saline infusion
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Peak plasma cortisol
680 nmol/l
oxytocin
Peak plasma cortisol
656 nmol/l
saline
Source sentences
Summary
There were no significant differences in plasma concentrations of ACTH, cortisol, GH or prolactin between saline and oxytocin infusion.
2 context sentences(design, population, supporting numbers)
Summary · context
peak plasma cortisol (oxytocin 680 +/- 47 nmol/l: saline 656 +/- 40 nmol/l)
Summary · context
The responses of plasma adrenocorticotrophin (ACTH), cortisol, growth hormone (GH) and prolactin to insulin-induced hypoglycaemia were studied in six lean male subjects (age 22-29 years). Intravenous insulin tests were performed with and without oxytocin infusion.
Report a problemFND-0285522004
05HumanRandomized controlled trialEfficacy outcome
In six lean men, peak plasma growth hormone after insulin-induced hypoglycaemia did not differ significantly between oxytocin and saline infusion.
In plain wordsIn six lean men, oxytocin infusion did not change the peak growth hormone response to low blood sugar compared with saline.
Peptide
Oxytocin
Outcome
No significant changePeak plasma growth hormone response to hypoglycaemia
Study
n = 6
Comparator
Saline infusion
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Peak plasma GH
96 mU/l
oxytocin
Peak plasma GH
106 mU/l
saline
Source sentences
Summary
There were no significant differences in plasma concentrations of ACTH, cortisol, GH or prolactin between saline and oxytocin infusion.
2 context sentences(design, population, supporting numbers)
Summary · context
peak GH (oxytocin 96 +/- 17.8 mU/l; saline 106 +/- 18.6 mU/l)
Summary · context
The responses of plasma adrenocorticotrophin (ACTH), cortisol, growth hormone (GH) and prolactin to insulin-induced hypoglycaemia were studied in six lean male subjects (age 22-29 years). Intravenous insulin tests were performed with and without oxytocin infusion.
Report a problemFND-0285522005
06HumanRandomized controlled trialEfficacy outcome
In six lean men, peak plasma prolactin after insulin-induced hypoglycaemia did not differ significantly between oxytocin and saline infusion.
In plain wordsIn six lean men, oxytocin infusion did not change the peak prolactin response to low blood sugar compared with saline.
Peptide
Oxytocin
Outcome
No significant changePeak plasma prolactin response to hypoglycaemia
Study
n = 6
Comparator
Saline infusion
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Peak plasma prolactin
1332 mU/l
oxytocin
Peak plasma prolactin
1242 mU/l
saline
Source sentences
Summary
There were no significant differences in plasma concentrations of ACTH, cortisol, GH or prolactin between saline and oxytocin infusion.
2 context sentences(design, population, supporting numbers)
Summary · context
prolactin (oxytocin 1332 +/- 239 mU/l; saline 1242 +/- 273 mU/l)
Summary · context
The responses of plasma adrenocorticotrophin (ACTH), cortisol, growth hormone (GH) and prolactin to insulin-induced hypoglycaemia were studied in six lean male subjects (age 22-29 years). Intravenous insulin tests were performed with and without oxytocin infusion.
Report a problemFND-0285522006

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

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