Comparison of the effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the cat gastric fundus.

D'Amato M, De Beurme FA, Lefebvre RA

European journal of pharmacology1 Jul 1988Cited by 32 (Europe PMC)

PMID2850204DOI10.1016/0014-2999(88)90837-0PepBankPUB-02850204

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In cat gastric fundus muscle strips, cumulative VIP induced a concentration-dependent relaxation.
In plain wordsIn lab tests on cat stomach muscle, VIP relaxed the muscle more as the concentration rose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of gastric fundus muscle strips
Study
catn: not reported in source
isolated circular and longitudinal muscle strips of the cat gastric fundus
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
while cumulative administration of VIP induced a concentration-dependent relaxation.
1 context sentence(design, population, supporting numbers)
Summary · context
The possible involvement of vasoactive intestinal polypeptide (VIP) in the non-adrenergic non-cholinergic (NANC) relaxation of the cat gastric fundus was studied in circular and longitudinal muscle strips.
Report a problemFND-0285020401
02LabEx vivo tissueMechanism
In cat gastric fundus muscle strips, tetrodotoxin did not influence the relaxation induced by VIP at 10(-7) M.
In plain wordsIn lab tests on cat stomach muscle, blocking nerve signals did not change the muscle relaxation caused by VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP-induced relaxation with tetrodotoxin
Study
catn: not reported in source
isolated circular and longitudinal muscle strips of the cat gastric fundus
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10(-7) MAs given in this study (cat).
Source sentences
Summary
but did not influence the relaxation induced by VIP (10(-7) M); the latter was not influenced by hexamethonium or propranolol plus phentolamine.
1 context sentence(design, population, supporting numbers)
Summary · context
The possible involvement of vasoactive intestinal polypeptide (VIP) in the non-adrenergic non-cholinergic (NANC) relaxation of the cat gastric fundus was studied in circular and longitudinal muscle strips.
Report a problemFND-0285020402
03LabEx vivo tissueMechanism
In cat gastric fundus muscle strips, VIP-induced relaxation was not influenced by hexamethonium or by propranolol plus phentolamine.
In plain wordsIn lab tests on cat stomach muscle, other receptor blockers did not change the muscle relaxation caused by VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP-induced relaxation with hexamethonium or propranolol plus phentolamine
Study
catn: not reported in source
isolated circular and longitudinal muscle strips of the cat gastric fundus
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10(-7) MAs given in this study (cat).
Source sentences
Summary
the latter was not influenced by hexamethonium or propranolol plus phentolamine.
1 context sentence(design, population, supporting numbers)
Summary · context
The possible involvement of vasoactive intestinal polypeptide (VIP) in the non-adrenergic non-cholinergic (NANC) relaxation of the cat gastric fundus was studied in circular and longitudinal muscle strips.
Report a problemFND-0285020403
04LabEx vivo tissueMechanism
In cat gastric fundus muscle strips, trypsin and VIP antiserum prevented the relaxation induced by VIP.
In plain wordsIn lab tests on cat stomach muscle, breaking down VIP or neutralising it with antiserum stopped the relaxation VIP caused.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP-induced relaxation with trypsin or VIP antiserum
Study
catn: not reported in source
isolated circular and longitudinal muscle strips of the cat gastric fundus
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
Trypsin (30 min incubation) and VIP antiserum (1 h incubation) prevented the relaxation induced by VIP
1 context sentence(design, population, supporting numbers)
Summary · context
The possible involvement of vasoactive intestinal polypeptide (VIP) in the non-adrenergic non-cholinergic (NANC) relaxation of the cat gastric fundus was studied in circular and longitudinal muscle strips.
Report a problemFND-0285020404
05LabEx vivo tissueMechanism
In cat gastric fundus muscle strips, two putative VIP receptor antagonists did not influence the relaxation induced by VIP.
In plain wordsIn lab tests on cat stomach muscle, two proposed VIP receptor blockers did not change the muscle relaxation caused by VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP-induced relaxation with putative VIP receptor antagonists
Study
catn: not reported in source
isolated circular and longitudinal muscle strips of the cat gastric fundus
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
Two putative VIP receptor antagonists, [AcTyr1]hGRF-(1-40)OH and [4Cl-D-Phe6,Leu17]VIP, did not influence the relaxation induced by VIP or transmural stimulation.
1 context sentence(design, population, supporting numbers)
Summary · context
The possible involvement of vasoactive intestinal polypeptide (VIP) in the non-adrenergic non-cholinergic (NANC) relaxation of the cat gastric fundus was studied in circular and longitudinal muscle strips.
Report a problemFND-0285020405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.