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Study · Ex vivo tissue · rat · 1988

6 results

Quantitative autoradiographic mapping of neurohypophysial hormone binding sites in the rat forebrain and pituitary gland--II. Comparative study on the Long-Evans and Brattleboro strains.

Freund-Mercier MJ, Dietl MM, Stoeckel ME, Palacios JM, Richard P

Neuroscience1 Jul 1988Cited by 27 (Europe PMC)

PMID2843791 (opens in a new tab)DOI10.1016/0306-4522(88)90144-3 (opens in a new tab)PepBankPUB-02843791
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In the forebrains of Long-Evans and Brattleboro rats, [3H]oxytocin revealed the same types of binding sites in both strains, with noticeable variations in density in several areas.

    In plain wordsIn lab tests on rat brain slices, the same oxytocin binding sites were found in both strains, but their density differed in several areas.

    Peptide
    Oxytocin
    Outcome
    MixedTypes and densities of [3H]oxytocin binding sites in Long-Evans and Brattleboro brains
    Study

    ratn: not reported in source

    Forebrain and pituitary sections (quantitative autoradiography)
    Comparator
    Long-Evans rats vs Brattleboro rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 nMAs given in this study (rat).

    Source sentences

    Summary
    Quantitative autoradiography on sections incubated in the presence of 5 nM of either [3H]oxytocin or [3H]vasopressin revealed the presence of the same types of sites in the brains of both strains but noticeable variations in their densities were found in several areas.
  2. 02LabEx vivo tissueActivity measurement

    Oxytocin/vasopressin binding sites had the same locations and densities in the ventral subiculum, several amygdala nuclei, the bed nucleus of the stria terminalis and the olfactory tubercle in both strains.

    In plain wordsIn lab tests on rat brain slices, shared oxytocin and vasopressin binding sites had the same place and density in both strains in several areas.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin/vasopressin site density in ventral subiculum, amygdala, BST and olfactory tubercle
    Study

    ratn: not reported in source

    Forebrain and pituitary sections (quantitative autoradiography)
    Comparator
    Long-Evans rats vs Brattleboro rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 nMAs given in this study (rat).

    Source sentences

    Summary
    In the forebrain, oxytocin/vasopressin sites, which bind both peptides with similar high nanomolar affinities, had the same locations and densities in the ventral subiculum, in several nuclei of the amygdala, the bed nucleus of the stria terminalis and the olfactory tubercle.
    1 context sentence
    Summary · context
    The anatomical distribution and pharmacological characteristics of the different types of neurohypophysial hormone binding sites were compared in the forebrains and pituitary glands of Long-Evans rats and its mutant Brattleboro strain, genetically deficient in vasopressin.
  3. 03LabEx vivo tissueActivity measurement

    The density of oxytocin/vasopressin binding sites in the ventromedial hypothalamic nucleus was lower in the Brattleboro rat than in the Long-Evans rat.

    In plain wordsIn lab tests on rat brain slices, oxytocin and vasopressin binding sites were less dense in one hypothalamic area of Brattleboro than Long-Evans rats.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin/vasopressin site density in ventromedial hypothalamic nucleus
    Study

    ratn: not reported in source

    Forebrain and pituitary sections (quantitative autoradiography)
    Comparator
    Long-Evans rats vs Brattleboro rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 nMAs given in this study (rat).

    Source sentences

    Summary
    The density of such sites was, in contrast, lower in the ventromedial hypothalamic nucleus of the Brattleboro rat.
    1 context sentence
    Summary · context
    The anatomical distribution and pharmacological characteristics of the different types of neurohypophysial hormone binding sites were compared in the forebrains and pituitary glands of Long-Evans rats and its mutant Brattleboro strain, genetically deficient in vasopressin.
  4. 04LabEx vivo tissueActivity measurement

    Selective vasopressin sites bound [3H]oxytocin with a much lower affinity than [3H]vasopressin.

    In plain wordsIn lab tests on rat brain slices, vasopressin-selective sites bound oxytocin much more weakly than vasopressin.

    Peptide
    Oxytocin
    Outcome
    Not applicableAffinity of selective vasopressin sites for oxytocin
    Study

    ratn: not reported in source

    Forebrain and pituitary sections (quantitative autoradiography)
    Comparator
    [3H]vasopressin
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 nMAs given in this study (rat).

    Source sentences

    Summary
    Selective vasopressin sites which bind [3H]vasopressin with a nanomolar-range affinity and [3H]oxytocin with a much lower affinity showed more variations.
    1 context sentence
    Summary · context
    The anatomical distribution and pharmacological characteristics of the different types of neurohypophysial hormone binding sites were compared in the forebrains and pituitary glands of Long-Evans rats and its mutant Brattleboro strain, genetically deficient in vasopressin.
  5. 05LabEx vivo tissueActivity measurement

    In the hypothalamo-neurohypophysial system of the Long-Evans rat, [3H]oxytocin and [3H]vasopressin binding had characteristics different from those in other brain areas.

    In plain wordsIn lab tests on rat brain slices, oxytocin binding in the pituitary-linked hypothalamic system behaved differently from binding in other brain areas.

    Peptide
    Oxytocin
    Outcome
    Not applicableBinding characteristics in the hypothalamo-neurohypophysial system
    Study

    ratn: not reported in source

    Forebrain and pituitary sections (quantitative autoradiography)
    Comparator
    Other brain areas
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 nMAs given in this study (rat).

    Source sentences

    Summary
    In the hypothalamo-neurohypophysial system, [3H]oxytocin and [3H]vasopressin binding occurred in the Long-Evans rat with characteristics different from those found in other brain areas.
    1 context sentence
    Summary · context
    The anatomical distribution and pharmacological characteristics of the different types of neurohypophysial hormone binding sites were compared in the forebrains and pituitary glands of Long-Evans rats and its mutant Brattleboro strain, genetically deficient in vasopressin.
  6. 06LabEx vivo tissueActivity measurement

    In the Brattleboro rat, only low [3H]oxytocin binding was found, restricted to the magnocellular nuclei, and no [3H]vasopressin binding.

    In plain wordsIn lab tests on rat brain slices, Brattleboro rats showed only low oxytocin binding, limited to the magnocellular nuclei.

    Peptide
    Oxytocin
    Outcome
    Decrease[3H]oxytocin binding in Brattleboro rat hypothalamo-neurohypophysial system
    Study

    ratn: not reported in source

    Forebrain and pituitary sections (quantitative autoradiography)
    Comparator
    Long-Evans rats vs Brattleboro rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    5 nMAs given in this study (rat).

    Source sentences

    Summary
    In the Brattleboro rat, no [3H]vasopressin binding and only low [3H]oxytocin binding, restricted to the magnocellular nuclei
    1 context sentence
    Summary · context
    The anatomical distribution and pharmacological characteristics of the different types of neurohypophysial hormone binding sites were compared in the forebrains and pituitary glands of Long-Evans rats and its mutant Brattleboro strain, genetically deficient in vasopressin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

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