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Study · In vitro (cells) · mouse · 1988

7 results

Induction of calcitonin receptors by 1 alpha, 25-dihydroxyvitamin D3 in osteoclast-like multinucleated cells formed from mouse bone marrow cells.

Takahashi N, Akatsu T, Sasaki T, Nicholson GC, Moseley JM, Martin TJ, Suda T

Endocrinology1 Sept 1988Cited by 117 (Europe PMC)

PMID2841098 (opens in a new tab)DOI10.1210/endo-123-3-1504 (opens in a new tab)PepBankPUB-02841098
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In mouse marrow cultures, salmon calcitonin inhibited TRACP-positive multinucleated cell formation.

    In plain wordsIn cells from mouse marrow, salmon calcitonin inhibited osteoclast-like cell formation.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseTRACP-positive multinucleated cell formation
    Study

    mousen: not reported in source

    Mouse marrow cultures
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    1 alpha, 25-Dihydroxyvitamin D3 [1 alpha, 25 (OH)2D3] stimulated the formation of TRACP-positive MNCs, and salmon calcitonin (CT) inhibited it.
    1 context sentence
    Summary · context
    We have developed a mouse marrow culture system, in which multinucleated cells (MNCs) are formed within 6-8 days.
  2. 02LabIn vitro (cells)Mechanism

    In vitamin D-treated mouse marrow cultures, salmon calcitonin markedly stimulated cAMP production.

    In plain wordsIn cells from mouse marrow treated with vitamin D, salmon calcitonin increased cAMP production.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreasecAMP production
    Study

    mousen: not reported in source

    Mouse marrow cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    CT markedly stimulated cAMP production in the 1 alpha,25(OH)2D3-treated cultures.
    1 context sentence
    Summary · context
    We have developed a mouse marrow culture system, in which multinucleated cells (MNCs) are formed within 6-8 days.
  3. 03LabIn vitro (cells)Mechanism

    In mouse marrow cultures, calcitonin-dependent cAMP production increased with TRACP-positive multinucleated cell number.

    In plain wordsIn cells from mouse marrow, calcitonin-dependent cAMP production increased with the number of osteoclast-like cells.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreasecAMP production versus multinucleated cell number
    Study

    mousen: not reported in source

    Mouse marrow cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The CT-dependent cAMP production increased in parallel with the increase in the number of TRACP-positive MNCs formed.
    1 context sentence
    Summary · context
    We have developed a mouse marrow culture system, in which multinucleated cells (MNCs) are formed within 6-8 days.
  4. 04LabIn vitro (cells)Mechanism

    In freshly isolated mouse marrow cells, calcitonin did not induce cAMP accumulation.

    In plain wordsIn cells freshly isolated from mouse marrow, calcitonin did not induce cAMP accumulation.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changecAMP accumulation in fresh marrow cells
    Study

    mousen: not reported in source

    Freshly isolated mouse marrow cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither freshly isolated marrow cells nor cells cultured without 1 alpha, 25(OH)2D3 showed CT-induced cAMP accumulation.
    1 context sentence
    Summary · context
    We have developed a mouse marrow culture system, in which multinucleated cells (MNCs) are formed within 6-8 days.
  5. 05LabIn vitro (cells)Mechanism

    In mouse marrow cells cultured without vitamin D, calcitonin did not induce cAMP accumulation.

    In plain wordsIn cells from mouse marrow cultured without vitamin D, calcitonin did not induce cAMP accumulation.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changecAMP accumulation without vitamin D culture
    Study

    mousen: not reported in source

    Mouse marrow cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither freshly isolated marrow cells nor cells cultured without 1 alpha, 25(OH)2D3 showed CT-induced cAMP accumulation.
    1 context sentence
    Summary · context
    We have developed a mouse marrow culture system, in which multinucleated cells (MNCs) are formed within 6-8 days.
  6. 06LabIn vitro (cells)Activity measurement

    In mouse marrow-derived multinucleated cells, calcitonin induced cytoplasmic contraction.

    In plain wordsIn cells derived from mouse marrow, calcitonin induced cytoplasmic contraction.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseCytoplasmic contraction of marrow-derived multinucleated cells
    Study

    mousen: not reported in source

    Mouse marrow cultures
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, CT induced cytoplasmic contraction of both marrow-derived MNCs and isolated osteoclasts.
    1 context sentence
    Summary · context
    We have developed a mouse marrow culture system, in which multinucleated cells (MNCs) are formed within 6-8 days.
  7. 07LabIn vitro (cells)Activity measurement

    In isolated mouse osteoclasts, calcitonin induced cytoplasmic contraction.

    In plain wordsIn isolated mouse bone-resorbing cells, calcitonin induced cytoplasmic contraction.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseCytoplasmic contraction of isolated osteoclasts
    Study

    mousen: not reported in source

    Isolated mouse osteoclasts
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, CT induced cytoplasmic contraction of both marrow-derived MNCs and isolated osteoclasts.
    2 context sentences
    Summary · context
    Mouse marrow cells cultured for 8 days with 10 nM 1 alpha, 25(OH)2D3 and freshly isolated authentic mouse osteoclasts were incubated with [125I]-salmon CT in the presence or absence of excess amounts of unlabeled CT, stained for TRACP, and processed for autoradiography.
    Summary · context
    We have developed a mouse marrow culture system, in which multinucleated cells (MNCs) are formed within 6-8 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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