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Study · Measured the body's own peptide · 1988

5 results

Delta sleep-inducing peptide response to human corticotropin-releasing hormone (CRH) in major depressive disorder. Comparison with CRH-induced corticotropin and cortisol secretion.

Lesch KP, Widerlöv E, Ekman R, Laux G, Schulte HM, Pfüller H, Beckmann H

Biological psychiatry1 Jun 1988Cited by 11 (Europe PMC)

PMID2839244 (opens in a new tab)DOI10.1016/0006-3223(88)90271-5 (opens in a new tab)PepBankPUB-02839244
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with major depressive disorder, basal plasma DSIP concentrations were higher than in controls.

    In plain wordsIn people with major depression, the body's own DSIP levels at rest were higher than in healthy adults.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseBasal plasma DSIP concentration
    Study

    n = 24

    Comparator
    Healthy controls
    Outcome group
    Sleep · Mental health and mood

    Source sentences

    Summary
    Basal DSIP and cortisol concentrations were highly correlated and were higher in depressives than in controls.
    1 context sentence
    Summary · context
    Twenty-four subjects (12 patients with major depressive disorder and 12 controls matched for sex and age) received 100 micrograms synthetic human corticotropin-releasing hormone (hCRH) as an iv bolus dose.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Basal DSIP and basal cortisol concentrations were both negatively correlated with the DSIP response to CRH.

    In plain wordsPeople with higher natural DSIP and cortisol levels at rest had a smaller DSIP response to CRH.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableCorrelation of DSIP response to hCRH with basal DSIP and cortisol
    Study

    n = 24

    Outcome group
    Sleep · Mental health and mood

    Source sentences

    Summary
    Basal DSIP and cortisol concentrations were highly correlated and were higher in depressives than in controls. Both were negatively correlated with the DSIP responses to hCRH.
    1 context sentence
    Summary · context
    Twenty-four subjects (12 patients with major depressive disorder and 12 controls matched for sex and age) received 100 micrograms synthetic human corticotropin-releasing hormone (hCRH) as an iv bolus dose.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In patients with major depressive disorder and matched controls, basal plasma DSIP and cortisol concentrations were highly correlated.

    In plain wordsIn people with major depression and healthy adults, the body's own DSIP and cortisol levels at rest were closely linked.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableCorrelation of basal DSIP with basal cortisol
    Study

    n = 24

    Outcome group
    Sleep · Mental health and mood

    Source sentences

    Summary
    Basal DSIP and cortisol concentrations were highly correlated and were higher in depressives than in controls.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In healthy subjects, plasma DSIP concentrations rose slightly but steadily after a CRH bolus.

    In plain wordsIn healthy adults, the body's own DSIP levels rose slightly after a dose of CRH.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreasePlasma DSIP response to hCRH in healthy subjects
    Study

    n = 12

    Comparator
    Baseline
    Outcome group
    Sleep · Mental health and mood

    Source sentences

    Summary
    Healthy subjects exhibited a slight, but sustained, increase of plasma delta sleep-inducing peptide (DSIP) concentrations
    1 context sentence
    Summary · context
    Twenty-four subjects (12 patients with major depressive disorder and 12 controls matched for sex and age) received 100 micrograms synthetic human corticotropin-releasing hormone (hCRH) as an iv bolus dose.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In patients with major depressive disorder, plasma DSIP levels fell markedly after a CRH bolus, unlike in healthy controls.

    In plain wordsIn people with major depression, the body's own DSIP levels fell sharply after CRH, unlike in healthy adults.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreasePlasma DSIP response to hCRH in depressed patients
    Study

    n = 12

    Comparator
    Healthy controls
    Outcome group
    Sleep · Mental health and mood

    Source sentences

    Summary
    whereas a marked reduction of DSIP levels was found in depressives.
    1 context sentence
    Summary · context
    Twenty-four subjects (12 patients with major depressive disorder and 12 controls matched for sex and age) received 100 micrograms synthetic human corticotropin-releasing hormone (hCRH) as an iv bolus dose.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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