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Study · Animal study (in vivo) · hartley guinea pig, lewis rat and guinea pig · 1988

7 results

Suppression of acute experimental allergic encephalomyelitis by synthetic serum thymic factor. Clinical, histopathological, and immunohistochemical studies.

Kato S, Nakamura H

Acta neuropathologica1 Jan 1988Cited by 10 (Europe PMC)

PMID2834909 (opens in a new tab)DOI10.1007/bf00687786 (opens in a new tab)PepBankPUB-02834909
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In guinea pigs and rats, synthetic serum thymic factor suppressed acute EAE symptoms with dosing that began before inoculation.

    In plain wordsIn guinea pigs and rats, serum thymic factor suppressed experimental allergic encephalomyelitis symptoms with dosing that began before inoculation.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseClinical EAE symptoms
    Study

    Hartley guinea pig and Lewis ratn: not reported in source

    Acute experimental allergic encephalomyelitis
    Comparator
    Untreated animals
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    30 micrograms/100 g body weight · subcutaneous · days -1, 4, 9 and 15As given in this study (Hartley guinea pig and Lewis rat).

    Source sentences

    Summary
    When a dose of 30 micrograms/100 g body weight of FTS was subcutaneously administered to the animals on days--1 (before inoculation), 4, 9 and 15 intermittently, clinical symptoms of acute EAE were suppressed.
    1 context sentence
    Summary · context
    Acute experimental allergic encephalomyelitis (EAE) was induced in Hartley guinea pigs and Lewis rats, which were then treated with synthetic serum thymic factor (FTS).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In guinea pigs, FTS reduced histopathological EAE severity compared with untreated animals.

    In plain wordsIn guinea pigs, FTS reduced tissue signs of experimental allergic encephalomyelitis compared with untreated animals.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseHistopathological EAE severity
    Study

    guinea pign: not reported in source

    Hartley guinea pigs with acute EAE
    Comparator
    Untreated animals
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    30 micrograms/100 g body weight · subcutaneous · days -1, 4, 9 and 15As given in this study (guinea pig).

    Source sentences

    Summary
    Histopathological evaluation showed that the severity of EAE in FTS-treated guinea pigs was less than in untreated guinea pigs.
    2 context sentences
    Summary · context
    When a dose of 30 micrograms/100 g body weight of FTS was subcutaneously administered to the animals on days--1 (before inoculation), 4, 9 and 15 intermittently, clinical symptoms of acute EAE were suppressed.
    Summary · context
    Acute experimental allergic encephalomyelitis (EAE) was induced in Hartley guinea pigs and Lewis rats, which were then treated with synthetic serum thymic factor (FTS).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with acute EAE, FTS reduced OX6+ cell numbers compared with untreated rats.

    In plain wordsIn rats with experimental allergic encephalomyelitis, FTS reduced OX6+ cells compared with untreated rats.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseOX6+ cells
    Study

    ratn: not reported in source

    Lewis rats with acute EAE
    Comparator
    Untreated animals
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 micrograms/100 g body weight · subcutaneous · days -1, 4, 9 and 15As given in this study (rat).

    Source sentences

    Summary
    Immunohistochemical examination showed that the numbers of OX6+, W3/25+, W3/13+ and OX19+ cells in FTS-treated rats were less than in untreated rats and that the number of OX8+ cells in FTS-treated rats was greater than in untreated rats.
    2 context sentences
    Summary · context
    When a dose of 30 micrograms/100 g body weight of FTS was subcutaneously administered to the animals on days--1 (before inoculation), 4, 9 and 15 intermittently, clinical symptoms of acute EAE were suppressed.
    Summary · context
    Acute experimental allergic encephalomyelitis (EAE) was induced in Hartley guinea pigs and Lewis rats, which were then treated with synthetic serum thymic factor (FTS).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with acute EAE, FTS reduced W3/25+ cell numbers compared with untreated rats.

    In plain wordsIn rats with experimental allergic encephalomyelitis, FTS reduced W3/25+ cells compared with untreated rats.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseW3/25+ cells
    Study

    ratn: not reported in source

    Lewis rats with acute EAE
    Comparator
    Untreated animals
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 micrograms/100 g body weight · subcutaneous · days -1, 4, 9 and 15As given in this study (rat).

    Source sentences

    Summary
    Immunohistochemical examination showed that the numbers of OX6+, W3/25+, W3/13+ and OX19+ cells in FTS-treated rats were less than in untreated rats and that the number of OX8+ cells in FTS-treated rats was greater than in untreated rats.
    2 context sentences
    Summary · context
    When a dose of 30 micrograms/100 g body weight of FTS was subcutaneously administered to the animals on days--1 (before inoculation), 4, 9 and 15 intermittently, clinical symptoms of acute EAE were suppressed.
    Summary · context
    Acute experimental allergic encephalomyelitis (EAE) was induced in Hartley guinea pigs and Lewis rats, which were then treated with synthetic serum thymic factor (FTS).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with acute EAE, FTS reduced W3/13+ cell numbers compared with untreated rats.

    In plain wordsIn rats with experimental allergic encephalomyelitis, FTS reduced W3/13+ cells compared with untreated rats.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseW3/13+ cells
    Study

    ratn: not reported in source

    Lewis rats with acute EAE
    Comparator
    Untreated animals
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 micrograms/100 g body weight · subcutaneous · days -1, 4, 9 and 15As given in this study (rat).

    Source sentences

    Summary
    Immunohistochemical examination showed that the numbers of OX6+, W3/25+, W3/13+ and OX19+ cells in FTS-treated rats were less than in untreated rats and that the number of OX8+ cells in FTS-treated rats was greater than in untreated rats.
    2 context sentences
    Summary · context
    When a dose of 30 micrograms/100 g body weight of FTS was subcutaneously administered to the animals on days--1 (before inoculation), 4, 9 and 15 intermittently, clinical symptoms of acute EAE were suppressed.
    Summary · context
    Acute experimental allergic encephalomyelitis (EAE) was induced in Hartley guinea pigs and Lewis rats, which were then treated with synthetic serum thymic factor (FTS).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with acute EAE, FTS reduced OX19+ cell numbers compared with untreated rats.

    In plain wordsIn rats with experimental allergic encephalomyelitis, FTS reduced OX19+ cells compared with untreated rats.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseOX19+ cells
    Study

    ratn: not reported in source

    Lewis rats with acute EAE
    Comparator
    Untreated animals
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 micrograms/100 g body weight · subcutaneous · days -1, 4, 9 and 15As given in this study (rat).

    Source sentences

    Summary
    Immunohistochemical examination showed that the numbers of OX6+, W3/25+, W3/13+ and OX19+ cells in FTS-treated rats were less than in untreated rats and that the number of OX8+ cells in FTS-treated rats was greater than in untreated rats.
    2 context sentences
    Summary · context
    When a dose of 30 micrograms/100 g body weight of FTS was subcutaneously administered to the animals on days--1 (before inoculation), 4, 9 and 15 intermittently, clinical symptoms of acute EAE were suppressed.
    Summary · context
    Acute experimental allergic encephalomyelitis (EAE) was induced in Hartley guinea pigs and Lewis rats, which were then treated with synthetic serum thymic factor (FTS).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with acute EAE, FTS increased OX8+ cell numbers compared with untreated rats.

    In plain wordsIn rats with experimental allergic encephalomyelitis, FTS increased OX8+ cells compared with untreated rats.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseOX8+ cells
    Study

    ratn: not reported in source

    Lewis rats with acute EAE
    Comparator
    Untreated animals
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 micrograms/100 g body weight · subcutaneous · days -1, 4, 9 and 15As given in this study (rat).

    Source sentences

    Summary
    Immunohistochemical examination showed that the numbers of OX6+, W3/25+, W3/13+ and OX19+ cells in FTS-treated rats were less than in untreated rats and that the number of OX8+ cells in FTS-treated rats was greater than in untreated rats.
    2 context sentences
    Summary · context
    When a dose of 30 micrograms/100 g body weight of FTS was subcutaneously administered to the animals on days--1 (before inoculation), 4, 9 and 15 intermittently, clinical symptoms of acute EAE were suppressed.
    Summary · context
    Acute experimental allergic encephalomyelitis (EAE) was induced in Hartley guinea pigs and Lewis rats, which were then treated with synthetic serum thymic factor (FTS).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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