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Study · Not a test of the peptide alone · 1988

5 results

[3H]-[Thr4,Gly7]OT: a highly selective ligand for central and peripheral OT receptors.

Elands J, Barberis C, Jard S

The American journal of physiology1 Jan 1988Cited by 71 (Europe PMC)

PMID2827511 (opens in a new tab)DOI10.1152/ajpendo.1988.254.1.e31 (opens in a new tab)PepBankPUB-02827511
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat tissue membranes, the tritiated agonist [Thr4,Gly7]oxytocin selectively labelled oxytocin receptors.

    In plain wordsIn lab tests on rat tissue, a labelled oxytocin-like compound bound selectively to oxytocin receptors.

    Peptide
    Oxytocin
    Outcome
    Not applicableSelectivity of [3H]-[Thr4,Gly7]oxytocin for oxytocin receptors
    Study

    ratn: not reported in source

    Hippocampal synaptic plasma membranes, mammary gland and uterus
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    We demonstrated that this ligand labels oxytocin receptors selectively.
    1 context sentence
    Summary · context
    Oxytocin receptors in rat hippocampal synaptic plasma membranes were compared with mammary gland and uterine oxytocin receptors.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat hippocampal, mammary gland and uterine membranes, the ligand bound oxytocin receptors with high affinity (equilibrium dissociation constants of 1.0 to 2.0 nM).

    In plain wordsIn lab tests on rat tissue, an oxytocin-like labelled compound bound oxytocin receptors tightly in all three tissues.

    Peptide
    Oxytocin
    Outcome
    Not applicableEquilibrium dissociation constant of oxytocin receptor ligand
    Study

    ratn: not reported in source

    Hippocampal synaptic plasma membranes, mammary gland and uterus
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    Kd
    1 to 2 nM
    oxytocin receptors, hippocampus, mammary gland, uterus

    Source sentences

    Summary
    Scatchard analyses revealed a high affinity for all the oxytocin receptors investigated, with equilibrium dissociation constants between 1.0 and 2.0 nM.
    1 context sentence
    Summary · context
    Oxytocin receptors in rat hippocampal synaptic plasma membranes were compared with mammary gland and uterine oxytocin receptors.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In rat tissue membranes, the ligand bound to a single population of receptor sites.

    In plain wordsIn lab tests on rat tissue, the labelled compound bound to one kind of receptor site.

    Peptide
    Oxytocin
    Outcome
    Not applicableNumber of receptor binding site populations
    Study

    ratn: not reported in source

    Hippocampal synaptic plasma membranes, mammary gland and uterus
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Binding appeared to take place at a single population of receptor sites.
    1 context sentence
    Summary · context
    Oxytocin receptors in rat hippocampal synaptic plasma membranes were compared with mammary gland and uterine oxytocin receptors.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In competition experiments, arginine vasopressin bound hippocampal oxytocin receptors with high affinity, and mammary gland and uterine oxytocin receptors did not discriminate more efficiently between oxytocin and arginine vasopressin.

    In plain wordsIn lab tests on rat tissue, vasopressin bound oxytocin receptors well, and mammary and uterine receptors did not separate oxytocin from vasopressin better.

    Peptide
    Oxytocin
    Outcome
    MixedDiscrimination between oxytocin and arginine vasopressin at oxytocin receptors
    Study

    ratn: not reported in source

    Hippocampal synaptic plasma membranes, mammary gland and uterus
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Competition experiments confirmed the high affinity of arginine vasopressin for hippocampal oxytocin receptors but also revealed that mammary gland and uterine oxytocin receptors do not discriminate more efficiently between oxytocin and arginine vasopressin.
    1 context sentence
    Summary · context
    Oxytocin receptors in rat hippocampal synaptic plasma membranes were compared with mammary gland and uterine oxytocin receptors.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  5. 05LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    Applying different concentrations of Mg ions did not affect the lack of specificity between oxytocin and arginine vasopressin.

    In plain wordsIn lab tests on rat tissue, changing magnesium ion levels did not change how poorly receptors told oxytocin from vasopressin.

    Peptide
    Oxytocin
    Outcome
    No significant changeEffect of Mg ions on receptor specificity
    Study

    ratn: not reported in source

    Hippocampal synaptic plasma membranes, mammary gland and uterus
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    This lack in specificity is not affected by applying different concentrations of Mg ions.
    1 context sentence
    Summary · context
    Oxytocin receptors in rat hippocampal synaptic plasma membranes were compared with mammary gland and uterine oxytocin receptors.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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