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Study · Not a test of the peptide alone · 1989

5 results

Binding of a growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sites.

Codd EE, Shu AY, Walker RF

Neuropharmacology1 Oct 1989Cited by 72 (Europe PMC)

PMID2812284 (opens in a new tab)DOI10.1016/0028-3908(89)90129-9 (opens in a new tab)PepBankPUB-02812284
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01LabNot a test of GHRP-6 aloneIn vitro (cell-free)Mechanism

    In membrane assays, radiolabeled GHRP bound reversibly and saturably to hypothalamic sites.

    In plain wordsIn lab tests, labeled GHRP bound reversibly to a limited number of hypothalamic membrane sites.

    Peptide
    GHRP-6
    Outcome
    Not applicableHypothalamic binding
    Study

    n: not reported in source

    hypothalamic and anterior pituitary membrane fragments
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Membrane fragments from both the hypothalamus and anterior pituitary tissue were found to contain sites to which [3H]SK&F 110679 reversibly and saturably bound.
    1 context sentence
    Summary · context
    In an attempt to understand its mode of action better, a binding assay for the peptide was established using a ligand which had been tritium labelled at the D-Trp2 residue.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02LabNot a test of GHRP-6 aloneIn vitro (cell-free)Mechanism

    In membrane assays, radiolabeled GHRP bound reversibly and saturably to anterior pituitary sites.

    In plain wordsIn lab tests, labeled GHRP bound reversibly to a limited number of anterior pituitary membrane sites.

    Peptide
    GHRP-6
    Outcome
    Not applicableAnterior pituitary binding
    Study

    n: not reported in source

    hypothalamic and anterior pituitary membrane fragments
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Membrane fragments from both the hypothalamus and anterior pituitary tissue were found to contain sites to which [3H]SK&F 110679 reversibly and saturably bound.
    1 context sentence
    Summary · context
    In an attempt to understand its mode of action better, a binding assay for the peptide was established using a ligand which had been tritium labelled at the D-Trp2 residue.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03LabNot a test of GHRP-6 aloneIn vitro (cell-free)Mechanism

    In membrane assays, GHRP binding in both tissues resolved into two components with affinities in distinct ranges.

    In plain wordsIn lab tests, GHRP binding in both tissues had two components with different affinities.

    Peptide
    GHRP-6
    Outcome
    Not applicableBinding components and affinities
    Study

    n: not reported in source

    hypothalamic and anterior pituitary membrane fragments
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The Kd's obtained were in the 10(-8) M and 10(-5) M range.
    2 context sentences
    Summary · context
    The binding curves for [3H]SK&F 110679 to membrane fragments of both hypothalamus and anterior pituitary were resolved into two binding components with the computer program LIGAND.
    Summary · context
    In an attempt to understand its mode of action better, a binding assay for the peptide was established using a ligand which had been tritium labelled at the D-Trp2 residue.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 04LabNot a test of GHRP-6 aloneIn vitro (cell-free)Mechanism

    Across GHRP-related peptides, hypothalamic binding correlated significantly with GH release potency.

    In plain wordsIn lab tests, binding of GHRP-related peptides to hypothalamic sites correlated with growth hormone release.

    Peptide
    GHRP-6
    Outcome
    Not applicableHypothalamic binding and GH release correlation
    Study

    n: not reported in source

    hypothalamic and anterior pituitary membrane fragments
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    For sites in both the hypothalamus and pituitary, a significant correlation between binding and the release of growth hormone was obtained.
    2 context sentences
    Summary · context
    The relationship of these binding sites to the growth hormone-releasing activity of the peptide was explored by examining the relationship between the binding and potency in releasing growth hormone of a series of peptides related to SK&F 110679.
    Summary · context
    In an attempt to understand its mode of action better, a binding assay for the peptide was established using a ligand which had been tritium labelled at the D-Trp2 residue.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  5. 05LabNot a test of GHRP-6 aloneIn vitro (cell-free)Mechanism

    Across GHRP-related peptides, pituitary binding correlated significantly with GH release potency.

    In plain wordsIn lab tests, binding of GHRP-related peptides to pituitary sites correlated with growth hormone release.

    Peptide
    GHRP-6
    Outcome
    Not applicablePituitary binding and GH release correlation
    Study

    n: not reported in source

    hypothalamic and anterior pituitary membrane fragments
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    For sites in both the hypothalamus and pituitary, a significant correlation between binding and the release of growth hormone was obtained.
    2 context sentences
    Summary · context
    The relationship of these binding sites to the growth hormone-releasing activity of the peptide was explored by examining the relationship between the binding and potency in releasing growth hormone of a series of peptides related to SK&F 110679.
    Summary · context
    In an attempt to understand its mode of action better, a binding assay for the peptide was established using a ligand which had been tritium labelled at the D-Trp2 residue.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:59 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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