In immunosuppressed tumor-bearing mice, thymosin alpha‑1 for 4 days followed by interferon restored normal NK cell activity, where interferon alone gave lower or no improvement.
In plain wordsIn tumor-bearing mice, thymosin alpha‑1 followed by interferon restored NK cell activity better than interferon alone.
- Peptide
- Thymosin alpha-1
- Outcome
- IncreaseNK cell activity
- Study
mousen: not reported in source
tumor-bearing, immunosuppressed mice- Comparator
- IFN alone
- Outcome group
- Immune response · Immune and inflammation
- Studied dose
- 200 micrograms/kg · 4 daysAs given in this study (mouse).
Source sentences
On the other hand, the same treatment led to lower or no improvement of NK responses if the treatment was given 13 or 17 days after tumor inoculation, at a time when tumor growth causes immunosuppression. However, combination treatment with TH (200 micrograms/kg) for 4 days, followed by IFN was foun…
1 context sentence(design, population, supporting numbers)
We have investigated the possibility of thymosin alpha 1 (TH) cooperating with alpha beta-interferon (IFN) in boosting natural killer (NK) activity in tumor-bearing, immunosuppressed mice in vivo.