In human monocytes, the IL-1-inducing activity of purified TF5 fractions was not due to thymosin alpha‑1.
In plain wordsIn lab tests of human blood cells, thymosin alpha‑1 did not account for the IL-1 activity of the thymosin preparation.
- Peptide
- Thymosin alpha-1
- Outcome
- No significant changeIL-1-like factor production by monocytes
- Study
humann: not reported in source
Human peripheral blood monocytes- Outcome group
- Immune response · Immune and inflammation
- Studied dose
- Dose not stated
Source sentences
Studies with further purified TF5 fractions show that this activity is not due to the well-characterized peptide, thymosin alpha 1 (T alpha 1), but rather a new thymosin peptide(s) isolated from a more basic fraction.
1 context sentence(design, population, supporting numbers)
Incubation of human peripheral blood monocytes (PBM) with a partially purified thymic preparation, thymosin fraction (TF5), results in a dose dependent production of an interleukin-1 (IL-1)-like factor.