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Study · Animal study (in vivo) · rat · 1989

6 results

[The role of the brain monoaminergic systems in the anti-alcohol action of dermorphin and the delta-sleep peptide].

Gromova EA, Bobkova NV, Plakkhinas LA, Deĭgin VI, Iarova EP

Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova1 May 1989

PMID2767269 (opens in a new tab)PepBankPUB-02767269
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats chronically treated with ethanol, DSIP significantly reduced volitional alcohol intake for 3-4 weeks.

    In plain wordsIn rats given alcohol over time, DSIP reduced voluntary alcohol drinking for several weeks.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseVolitional alcohol intake
    Study

    ratn: not reported in source

    chronic ethanol treatment, male Wistar rats
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    200 mg/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Measurements

    Duration of reduced intake
    3 to 4 weeks
    DSIP

    Source sentences

    Summary
    Both peptides (200 mg/kg, i. p., daily during 10 days) significantly reduced volitional alcohol intake for 3-4 weeks.
    1 context sentence
    Summary · context
    The effects of dermorphin and DSIP were studied in male Wistar rats chronically treated with ethanol.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In alcohol-treated rats, DSIP was associated with a marked decrease in hypothalamic serotonin.

    In plain wordsIn rats given alcohol, DSIP treatment came with a marked drop in serotonin in a brain area.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseHypothalamic serotonin level
    Study

    ratn: not reported in source

    chronic ethanol treatment, male Wistar rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    200 mg/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    These effects were associated with a marked decrease in serotonin and its metabolite 5-HIAA levels in the hypothalamus.
    2 context sentences
    Summary · context
    Both peptides (200 mg/kg, i. p., daily during 10 days) significantly reduced volitional alcohol intake for 3-4 weeks.
    Summary · context
    The effects of dermorphin and DSIP were studied in male Wistar rats chronically treated with ethanol.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In alcohol-treated rats, DSIP was associated with a marked decrease in hypothalamic 5-HIAA, a serotonin metabolite.

    In plain wordsIn rats given alcohol, DSIP treatment came with a marked drop in a serotonin breakdown product in a brain area.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseHypothalamic 5-HIAA level
    Study

    ratn: not reported in source

    chronic ethanol treatment, male Wistar rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    200 mg/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    These effects were associated with a marked decrease in serotonin and its metabolite 5-HIAA levels in the hypothalamus.
    2 context sentences
    Summary · context
    Both peptides (200 mg/kg, i. p., daily during 10 days) significantly reduced volitional alcohol intake for 3-4 weeks.
    Summary · context
    The effects of dermorphin and DSIP were studied in male Wistar rats chronically treated with ethanol.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats chronically treated with ethanol, dermorphin significantly reduced volitional alcohol intake for 3-4 weeks.

    In plain wordsIn rats chronically treated with ethanol, dermorphin significantly reduced voluntary alcohol intake for 3-4 weeks.

    Peptide
    Dermorphin
    Outcome
    DecreaseVolitional alcohol intake
    Study

    ratn: not reported in source

    Male Wistar rats chronically treated with ethanol
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    200 mg/kg · i. p. · 10 daysAs given in this study (rat).

    Measurements

    Effect duration
    3 to 4 weeks
    reduced volitional alcohol intake

    Source sentences

    Summary
    Both peptides (200 mg/kg, i. p., daily during 10 days) significantly reduced volitional alcohol intake for 3-4 weeks.
    1 context sentence
    Summary · context
    The effects of dermorphin and DSIP were studied in male Wistar rats chronically treated with ethanol.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In male Wistar rats chronically treated with ethanol, dermorphin's effects were associated with markedly decreased hypothalamic serotonin levels.

    In plain wordsIn rats chronically treated with ethanol, dermorphin's effects were linked to markedly lower serotonin levels in the hypothalamus.

    Peptide
    Dermorphin
    Outcome
    DecreaseHypothalamic serotonin levels
    Study

    ratn: not reported in source

    Male Wistar rats chronically treated with ethanol
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    200 mg/kg · i. p. · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    These effects were associated with a marked decrease in serotonin and its metabolite 5-HIAA levels in the hypothalamus.
    2 context sentences
    Summary · context
    Both peptides (200 mg/kg, i. p., daily during 10 days) significantly reduced volitional alcohol intake for 3-4 weeks.
    Summary · context
    The effects of dermorphin and DSIP were studied in male Wistar rats chronically treated with ethanol.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In male Wistar rats chronically treated with ethanol, dermorphin's effects were associated with markedly decreased hypothalamic 5-HIAA levels.

    In plain wordsIn rats chronically treated with ethanol, dermorphin's effects were linked to markedly lower 5-HIAA levels in the hypothalamus.

    Peptide
    Dermorphin
    Outcome
    DecreaseHypothalamic 5-HIAA levels
    Study

    ratn: not reported in source

    Male Wistar rats chronically treated with ethanol
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    200 mg/kg · i. p. · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    These effects were associated with a marked decrease in serotonin and its metabolite 5-HIAA levels in the hypothalamus.
    2 context sentences
    Summary · context
    Both peptides (200 mg/kg, i. p., daily during 10 days) significantly reduced volitional alcohol intake for 3-4 weeks.
    Summary · context
    The effects of dermorphin and DSIP were studied in male Wistar rats chronically treated with ethanol.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 6Current

    28 Oct 2026, 02:03 UTC

    The same notice was added 3 times, first on 27 Oct 2026, 18:20 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    27 Oct 2026, 16:32 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    12 Oct 2026, 17:28 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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