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Study · Animal study (in vivo) · mouse · 1989

5 results

Inhibition of wound repair by thymic hormones.

Barbul A, Shawe T, Frankel HL, Efron JE, Wasserkrug HL

Surgery1 Aug 1989Cited by 13 (Europe PMC)

PMID2763035 (opens in a new tab)PepBankPUB-02763035
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In normal mice, thymulin impaired wound breaking strength compared with saline.

    In plain wordsIn normal mice, thymulin reduced wound strength compared with saline.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseWound breaking strength
    Study

    mousen: not reported in source

    Normal euthymic mice with dorsal skin incision
    Comparator
    Saline
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    0.2 microgram/day · intramuscular · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results show that both thymic hormones impaired wound breaking strength and reparative collagen synthesis in normal and athymic mice.
    3 context sentences
    Summary · context
    (2) thymulin or facteur thymique serique (FTS), a naturally occurring circulating thymic hormone (0.2 microgram/day/IM); (3) control saline solution (0.1 ml/day/IM).
    Summary · context
    To further define the role of the thymus in wound healing, we studied the effects of two thymic hormones on fibroplasia in normal euthymic and in nude athymic mice.
    Summary · context
    All mice were killed 4 weeks after wounding, and wound breaking strength and hydroxyproline content of the sponge granulomas were measured.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In athymic mice, thymulin impaired wound breaking strength compared with saline.

    In plain wordsIn mice without a thymus, thymulin reduced wound strength compared with saline.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseWound breaking strength
    Study

    mousen: not reported in source

    Nude athymic mice with dorsal skin incision
    Comparator
    Saline
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    0.2 microgram/day · intramuscular · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results show that both thymic hormones impaired wound breaking strength and reparative collagen synthesis in normal and athymic mice.
    3 context sentences
    Summary · context
    (2) thymulin or facteur thymique serique (FTS), a naturally occurring circulating thymic hormone (0.2 microgram/day/IM); (3) control saline solution (0.1 ml/day/IM).
    Summary · context
    To further define the role of the thymus in wound healing, we studied the effects of two thymic hormones on fibroplasia in normal euthymic and in nude athymic mice.
    Summary · context
    All mice were killed 4 weeks after wounding, and wound breaking strength and hydroxyproline content of the sponge granulomas were measured.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In normal mice, thymulin impaired reparative collagen synthesis compared with saline.

    In plain wordsIn normal mice, thymulin reduced collagen production during wound repair compared with saline.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseReparative collagen synthesis
    Study

    mousen: not reported in source

    Normal euthymic mice with dorsal skin incision
    Comparator
    Saline
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    0.2 microgram/day · intramuscular · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results show that both thymic hormones impaired wound breaking strength and reparative collagen synthesis in normal and athymic mice.
    3 context sentences
    Summary · context
    (2) thymulin or facteur thymique serique (FTS), a naturally occurring circulating thymic hormone (0.2 microgram/day/IM); (3) control saline solution (0.1 ml/day/IM).
    Summary · context
    To further define the role of the thymus in wound healing, we studied the effects of two thymic hormones on fibroplasia in normal euthymic and in nude athymic mice.
    Summary · context
    All mice were killed 4 weeks after wounding, and wound breaking strength and hydroxyproline content of the sponge granulomas were measured.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In athymic mice, thymulin impaired reparative collagen synthesis compared with saline.

    In plain wordsIn mice without a thymus, thymulin reduced collagen production during wound repair compared with saline.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseReparative collagen synthesis
    Study

    mousen: not reported in source

    Nude athymic mice with dorsal skin incision
    Comparator
    Saline
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    0.2 microgram/day · intramuscular · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The results show that both thymic hormones impaired wound breaking strength and reparative collagen synthesis in normal and athymic mice.
    3 context sentences
    Summary · context
    (2) thymulin or facteur thymique serique (FTS), a naturally occurring circulating thymic hormone (0.2 microgram/day/IM); (3) control saline solution (0.1 ml/day/IM).
    Summary · context
    To further define the role of the thymus in wound healing, we studied the effects of two thymic hormones on fibroplasia in normal euthymic and in nude athymic mice.
    Summary · context
    All mice were killed 4 weeks after wounding, and wound breaking strength and hydroxyproline content of the sponge granulomas were measured.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, thymulin-induced wound healing impairment had equal magnitude in thymus-bearing and nude animals.

    In plain wordsIn mice, thymulin impaired wound healing equally in animals with and without a thymus.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeMagnitude of wound healing impairment
    Study

    mousen: not reported in source

    Normal euthymic and nude athymic wounded mice
    Comparator
    Thymus-bearing versus nude mice
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    0.2 microgram/day · intramuscular · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The magnitude of the wound healing impairment induced by the two hormones was equal in the thymus-bearing and in the nude mice.
    3 context sentences
    Summary · context
    The results show that both thymic hormones impaired wound breaking strength and reparative collagen synthesis in normal and athymic mice.
    Summary · context
    To further define the role of the thymus in wound healing, we studied the effects of two thymic hormones on fibroplasia in normal euthymic and in nude athymic mice.
    Summary · context
    All mice were killed 4 weeks after wounding, and wound breaking strength and hydroxyproline content of the sponge granulomas were measured.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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