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Study · In vitro (cells) · mouse · 1989

4 results

Developmental changes in arginine vasopressin receptors and testosterone stimulation in Leydig cells.

Tahri-Joutei A, Pointis G

Endocrinology1 Aug 1989Cited by 12 (Europe PMC)

PMID2752967 (opens in a new tab)DOI10.1210/endo-125-2-605 (opens in a new tab)PepBankPUB-02752967
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In purified mouse Leydig cells, 24-h pretreatment with oxytocin or vasopressin increased acute testosterone production by 1.3- to 3-fold at all ages except puberty.

    In plain wordsIn mouse testis cells in the lab, oxytocin or vasopressin pretreatment raised testosterone output, except in pubertal cells, which reacted more strongly.

    Peptide
    Oxytocin
    Outcome
    IncreaseAcute testosterone production after 24-h pretreatment, all ages except pubertal
    Study

    mousen: not reported in source

    Purified Leydig cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 24 hAs given in this study (mouse).

    Source sentences

    Summary
    A 24-h pretreatment by the neurohypophysial hormones significantly increased the acute (3-h) testosterone production by 1.3- to 3-fold at all ages studied, with the exception of pubertal Leydig cells which responded with a 5- to 7-fold increment of testosterone production (P less than 0.05).
    1 context sentence
    Summary · context
    The steroidogenic response of purified Leydig cells from mice at various ages (from 10-95 days old) was investigated after exposure of cells to arginine vasopressin (AVP) or oxytocin (OT).
  2. 02LabIn vitro (cells)Mechanism

    In purified pubertal mouse Leydig cells, 24-h pretreatment with oxytocin or vasopressin increased acute testosterone production 5- to 7-fold (P less than 0.05).

    In plain wordsIn mouse testis cells from pubertal animals in the lab, oxytocin or vasopressin pretreatment raised testosterone output 5- to 7-fold.

    Peptide
    Oxytocin
    Outcome
    IncreaseAcute testosterone production after 24-h pretreatment, pubertal cells
    Study

    mousen: not reported in source

    Purified Leydig cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 24 hAs given in this study (mouse).

    Source sentences

    Summary
    A 24-h pretreatment by the neurohypophysial hormones significantly increased the acute (3-h) testosterone production by 1.3- to 3-fold at all ages studied, with the exception of pubertal Leydig cells which responded with a 5- to 7-fold increment of testosterone production (P less than 0.05).
    1 context sentence
    Summary · context
    The steroidogenic response of purified Leydig cells from mice at various ages (from 10-95 days old) was investigated after exposure of cells to arginine vasopressin (AVP) or oxytocin (OT).
  3. 03LabIn vitro (cells)Activity measurement

    In mouse Leydig cells, the ED50 of oxytocin for stimulating testosterone production was 10 times higher than that of vasopressin.

    In plain wordsIn mouse testis cells in the lab, oxytocin needed a dose ten times higher than vasopressin to stimulate testosterone.

    Peptide
    Oxytocin
    Outcome
    Not applicablePotency of oxytocin versus vasopressin for testosterone stimulation
    Study

    mousen: not reported in source

    Purified Leydig cells
    Comparator
    Arginine vasopressin
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    ED50 ratio (oxytocin to vasopressin)
    10 times
    Leydig cells

    Source sentences

    Summary
    In addition, the ED50 for OT was 10 times higher than that for AVP.
    1 context sentence
    Summary · context
    The steroidogenic response of purified Leydig cells from mice at various ages (from 10-95 days old) was investigated after exposure of cells to arginine vasopressin (AVP) or oxytocin (OT).
  4. 04LabIn vitro (cells)Mechanism

    In mouse Leydig cells of all ages studied, 24-h pretreatment with oxytocin or vasopressin did not change hCG-stimulated testosterone production.

    In plain wordsIn mouse testis cells in the lab, 24-hour oxytocin or vasopressin pretreatment did not change testosterone output stimulated by hCG.

    Peptide
    Oxytocin
    Outcome
    No significant changehCG-stimulated testosterone production after 24-h pretreatment
    Study

    mousen: not reported in source

    Purified Leydig cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 24 hAs given in this study (mouse).

    Source sentences

    Summary
    No modification of hCG-stimulated testosterone production occurred after a 24-h pretreatment of Leydig cells by AVP or OT for all ages studied.
    1 context sentence
    Summary · context
    The steroidogenic response of purified Leydig cells from mice at various ages (from 10-95 days old) was investigated after exposure of cells to arginine vasopressin (AVP) or oxytocin (OT).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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