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Study · Animal study (in vivo) · mouse · 1989

4 results

Involvement of spinal noradrenergic system in the mechanism of an antinociceptive effect of delta-sleep-inducing peptide (DSIP).

Nakamura A, Sugao T, Yamaue K, Kobatake M, Shiomi H

Brain research1 Feb 1989Cited by 1 (Europe PMC)

PMID2713670 (opens in a new tab)DOI10.1016/0006-8993(89)91569-2 (opens in a new tab)PepBankPUB-02713670
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, reserpine pretreatment (3 mg/kg i.p.), which depleted monoamines, significantly reduced the antinociceptive effect of DSIP in the tail-pinch test.

    In plain wordsIn mice, depleting brain monoamines with reserpine reduced the pain-relieving effect of DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP antinociception after reserpine (tail-pinch test)
    Study

    mousen: not reported in source

    Comparator
    No reserpine pretreatment
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    In the tail-pinch test, the antinociceptive effect of DSIP was significantly reduced by the pretreatment with reserpine (3 mg/kg i.p.) which depleted endogenous monoamines.
    1 context sentence
    Summary · context
    We studied whether the antinociceptive effect produced by intracerebroventricular injection of delta-sleep-inducing peptide (DSIP) to mice involved the monoaminergic pathways that descended from brainstem to spinal cord (the descending inhibitory systems).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, intrathecal phentolamine, an alpha-adrenergic blocker, significantly antagonized the antinociceptive effect of DSIP in the tail-pinch and hot plate tests.

    In plain wordsIn mice, blocking alpha-adrenergic receptors in the spinal cord reduced the pain-relieving effect of DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP antinociception after phentolamine (tail-pinch and hot plate tests)
    Study

    mousen: not reported in source

    Comparator
    No phentolamine pretreatment
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    In both tail-pinch and hot plate tests, the antinociceptive effect of DSIP was significantly antagonized by the previous intrathecal administration of phentolamine (an alpha-adrenergic blocker)
    1 context sentence
    Summary · context
    We studied whether the antinociceptive effect produced by intracerebroventricular injection of delta-sleep-inducing peptide (DSIP) to mice involved the monoaminergic pathways that descended from brainstem to spinal cord (the descending inhibitory systems).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, intrathecal yohimbine, an alpha 2-adrenergic blocker, significantly antagonized the antinociceptive effect of DSIP in the tail-pinch and hot plate tests.

    In plain wordsIn mice, blocking alpha 2-adrenergic receptors in the spinal cord reduced the pain-relieving effect of DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP antinociception after yohimbine (tail-pinch and hot plate tests)
    Study

    mousen: not reported in source

    Comparator
    No yohimbine pretreatment
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    In both tail-pinch and hot plate tests, the antinociceptive effect of DSIP was significantly antagonized by the previous intrathecal administration of phentolamine (an alpha-adrenergic blocker) or yohimbine (an alpha 2-adrenergic blocker), but was unaffected by the pretreatment with methysergide (a…
    1 context sentence
    Summary · context
    We studied whether the antinociceptive effect produced by intracerebroventricular injection of delta-sleep-inducing peptide (DSIP) to mice involved the monoaminergic pathways that descended from brainstem to spinal cord (the descending inhibitory systems).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, pretreatment with the serotonin antagonist methysergide did not change the antinociceptive effect of DSIP.

    In plain wordsIn mice, blocking serotonin receptors did not change the pain-relieving effect of DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDSIP antinociception after methysergide (tail-pinch and hot plate tests)
    Study

    mousen: not reported in source

    Comparator
    No methysergide pretreatment
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    In both tail-pinch and hot plate tests, the antinociceptive effect of DSIP was
    2 context sentences
    Summary · context
    but was unaffected by the pretreatment with methysergide (a serotonin antagonist).
    Summary · context
    We studied whether the antinociceptive effect produced by intracerebroventricular injection of delta-sleep-inducing peptide (DSIP) to mice involved the monoaminergic pathways that descended from brainstem to spinal cord (the descending inhibitory systems).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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