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Study · Measured the body's own peptide · 1989

2 results

Vasopressin and oxytocin responses to hypertonic saline infusion: effect of the opioid antagonist naloxone.

Seckl JR, Johnson MR, Lightman SL

Clinical endocrinology1 May 1989Cited by 3 (Europe PMC)

PMID2605788 (opens in a new tab)DOI10.1111/j.1365-2265.1989.tb01422.x (opens in a new tab)PepBankPUB-02605788
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In six men, hypertonic saline infusion produced a small but significant decrease in plasma oxytocin.

    In plain wordsIn six men, salt-water infusion lowered the body's own oxytocin level slightly.

    Peptide
    Oxytocin
    Outcome
    DecreasePlasma oxytocin response to hypertonic saline
    Study

    n = 6

    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Hypertonic saline resulted in similar significant rises of plasma osmolality and AVP in both groups and a small but significant decrease in OT.
    1 context sentence
    Summary · context
    In two separate studies, six male subjects were infused with hypertonic saline (675 mmol/l, 0.05 ml/kg/min for 2 h) and either naloxone (4 mg bolus and 6 mg/h) or normal saline in random order.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialOther

    In six men given hypertonic saline, naloxone did not change the decrease in plasma oxytocin compared with normal saline.

    In plain wordsIn six men, naloxone did not alter the small fall in the body's own oxytocin level compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeEffect of naloxone on the oxytocin response to hypertonic saline
    Study

    n = 6

    Comparator
    Normal saline
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Hypertonic saline resulted in similar significant rises of plasma osmolality and AVP in both groups and a small but significant decrease in OT.
    2 context sentences
    Summary · context
    Endogenous opioids do not play an important role in the suppression of OT release when AVP is secreted in response to an osmotic stimulus in man.
    Summary · context
    In two separate studies, six male subjects were infused with hypertonic saline (675 mmol/l, 0.05 ml/kg/min for 2 h) and either naloxone (4 mg bolus and 6 mg/h) or normal saline in random order.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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