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Study · Measured the body's own peptide · 1989

3 results

Diminished thymosin alpha-1 levels in persons exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Stehr-Green PA, Naylor PH, Hoffman RE

Journal of toxicology and environmental health1 Jan 1989Cited by 9 (Europe PMC)

PMID2585536 (opens in a new tab)DOI10.1080/15287398909531349 (opens in a new tab)PepBankPUB-02585536
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In persons presumed exposed to TCDD, mean serum levels of the body's own thymosin alpha‑1 were significantly lower than in unexposed persons.

    In plain wordsPeople presumed to be exposed to dioxin had lower levels of the body's own thymosin alpha‑1 than unexposed people.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseSerum thymosin alpha-1 level, exposed versus unexposed
    Study

    n = 199

    Comparator
    Unexposed persons
    Outcome group
    Immune response · Immune and inflammation

    Measurements

    Mean Thya-1 serum level
    977.3 pg/ml
    exposed group
    Mean Thya-1 serum level
    1148.7 pg/ml
    unexposed group

    Source sentences

    Summary
    The exposed group had a significantly lower mean Thya-1 serum level (977.3 +/- 304.1 pg/ml vs. 1148.7 +/- 482.1 pg/ml, p less than .01 by t-test).
    2 context sentences
    Summary · context
    We examined thymosin alpha-1 (Thya-1) levels in sera from a group of 94 persons who were presumed to be exposed to TCDD from living, working, or recreating in a contaminated residential area.
    Summary · context
    We compared these results, along with results from in vitro and in vivo tests of immune function, with those from a group of 105 unexposed persons who were similar with regard to age, sex, and race.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Among TCDD-exposed persons, serum thymosin alpha‑1 levels showed a significant trend of decrease with more years of residence in the contaminated area.

    In plain wordsAmong people exposed to dioxin, the body's own thymosin alpha‑1 levels were lower the longer they lived in the area.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseThymosin alpha-1 level trend with years of residence
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    We also found a statistically significant trend of decreasing Thya-1 levels with increasing number of years of residence in the TCDD-contaminated area.
    2 context sentences
    Summary · context
    We examined thymosin alpha-1 (Thya-1) levels in sera from a group of 94 persons who were presumed to be exposed to TCDD from living, working, or recreating in a contaminated residential area.
    Summary · context
    We compared these results, along with results from in vitro and in vivo tests of immune function, with those from a group of 105 unexposed persons who were similar with regard to age, sex, and race.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In TCDD-exposed persons, thymosin alpha‑1 levels were not associated with other measures of immune function.

    In plain wordsIn people exposed to dioxin, the body's own thymosin alpha‑1 levels were not linked to other immune tests.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeAssociation of thymosin alpha-1 level with other measures of immune function
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    However, Thya-1 levels were not associated with other measures of immune function in the TCDD-exposed group.
    2 context sentences
    Summary · context
    We examined thymosin alpha-1 (Thya-1) levels in sera from a group of 94 persons who were presumed to be exposed to TCDD from living, working, or recreating in a contaminated residential area.
    Summary · context
    We compared these results, along with results from in vitro and in vivo tests of immune function, with those from a group of 105 unexposed persons who were similar with regard to age, sex, and race.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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