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Study · In vitro (cells) · mouse · 1985

2 results

Thymus hormones do not induce proliferative ability or cytolytic function in PNA+ cortical thymocytes.

Andrews P, Shortman K, Scollay R, Potworowski EF, Kruisbeek AM, Goldstein G, Trainin N, Bach JF

Cellular immunology1 Apr 1985Cited by 18 (Europe PMC)

PMID2581700 (opens in a new tab)DOI10.1016/0008-8749(85)90243-6 (opens in a new tab)PepBankPUB-02581700
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In mouse cortical thymocytes, FTS did not increase extended-clone precursor levels.

    In plain wordsIn cells from mice, FTS did not increase extended-clone precursor levels.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeExtended-clone precursors
    Study

    mousen: not reported in source

    sorted cortical thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In no case did the hormone preparations cause any increase in the level of PTL-p or CTL-p in the PNA+ or low H-2K thymocyte population, even though a conversion of only a few percent to functional cells could have been detected.
    2 context sentences
    Summary · context
    Murine cortical thymocytes, defined as the high peanut agglutinin (PNA) binding or as the low H-2K, major [86%] thymocyte subpopulation, were isolated by fluorescence-activated cell sorting.
    Summary · context
    The hormone preparations tested were crude or partially purified culture supernatants from thymus "epithelial" monolayers (TES), soluble extracts of thymic nonlymphoid tissue (STF), semipure thymus humoral factor (THF), and the pure peptides thymopoietin 32-36 (TP5) and "facteur thymique sérique" (FTS).
  2. 02LabIn vitro (cells)Activity measurement

    In mouse cortical thymocytes, FTS did not increase cytolytic-clone precursor levels.

    In plain wordsIn cells from mice, FTS did not increase cytolytic-clone precursor levels.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeCytolytic-clone precursors
    Study

    mousen: not reported in source

    sorted cortical thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In no case did the hormone preparations cause any increase in the level of PTL-p or CTL-p in the PNA+ or low H-2K thymocyte population, even though a conversion of only a few percent to functional cells could have been detected.
    2 context sentences
    Summary · context
    Murine cortical thymocytes, defined as the high peanut agglutinin (PNA) binding or as the low H-2K, major [86%] thymocyte subpopulation, were isolated by fluorescence-activated cell sorting.
    Summary · context
    The hormone preparations tested were crude or partially purified culture supernatants from thymus "epithelial" monolayers (TES), soluble extracts of thymic nonlymphoid tissue (STF), semipure thymus humoral factor (THF), and the pure peptides thymopoietin 32-36 (TP5) and "facteur thymique sérique" (FTS).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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