Effects of corticotropin-releasing factor (CRF), tuftsin and dermorphin on behavior of squirrel monkeys maintained by different events.

Nader MA, Barrett JE

Peptides1 Nov 1989Cited by 12 (Europe PMC)

PMID2576126DOI10.1016/0196-9781(89)90013-2PepBankPUB-02576126

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In squirrel monkeys, dermorphin selectively increased food-maintained responding when shock presentation maintained the other schedule component.
In plain wordsIn squirrel monkeys, dermorphin increased food-maintained responding when shock presentation maintained the other schedule component.
Peptide
Dermorphin
Outcome
IncreaseFood-maintained responding with shock presentation
Study
squirrel monkeyn: not reported in source
Operant responding under food and shock schedules
Outcome group
Locomotor and behavioral activity · Nervous system and cognition
Studied dose
0.3-30.0 micrograms/kg · intracerebroventricularAs given in this study (squirrel monkey).
Source sentences
Summary
The heptapeptide dermorphin selectively increased food-maintained responding when responding in the other component of the multiple schedule was maintained by shock presentation.
1 context sentence(design, population, supporting numbers)
Summary · context
were examined in squirrel monkeys trained to respond under a multiple 3-min fixed-interval schedule of food presentation and either shock presentation or stimulus-shock termination.
Report a problemFND-0257612601
02AnimalAnimal study (in vivo)Activity measurement
In squirrel monkeys, dermorphin decreased food-maintained response rates under the multiple food and stimulus-shock termination schedule.
In plain wordsIn squirrel monkeys, dermorphin decreased food-maintained responding under the food and stimulus-shock termination schedule.
Peptide
Dermorphin
Outcome
DecreaseFood-maintained responding with stimulus-shock termination
Study
squirrel monkeyn: not reported in source
Operant responding under food and shock schedules
Outcome group
Locomotor and behavioral activity · Nervous system and cognition
Studied dose
0.3-30.0 micrograms/kg · intracerebroventricularAs given in this study (squirrel monkey).
Source sentences
Summary
When responding was maintained by a multiple food, stimulus-shock termination schedule, dermorphin decreased response rates in both components.
1 context sentence(design, population, supporting numbers)
Summary · context
were examined in squirrel monkeys trained to respond under a multiple 3-min fixed-interval schedule of food presentation and either shock presentation or stimulus-shock termination.
Report a problemFND-0257612602
03AnimalAnimal study (in vivo)Activity measurement
In squirrel monkeys, dermorphin decreased stimulus-shock termination response rates under the multiple food and stimulus-shock termination schedule.
In plain wordsIn squirrel monkeys, dermorphin decreased stimulus-shock termination responding under the multiple schedule.
Peptide
Dermorphin
Outcome
DecreaseStimulus-shock termination response rates
Study
squirrel monkeyn: not reported in source
Operant responding under food and shock schedules
Outcome group
Locomotor and behavioral activity · Nervous system and cognition
Studied dose
0.3-30.0 micrograms/kg · intracerebroventricularAs given in this study (squirrel monkey).
Source sentences
Summary
When responding was maintained by a multiple food, stimulus-shock termination schedule, dermorphin decreased response rates in both components.
1 context sentence(design, population, supporting numbers)
Summary · context
were examined in squirrel monkeys trained to respond under a multiple 3-min fixed-interval schedule of food presentation and either shock presentation or stimulus-shock termination.
Report a problemFND-0257612603

Studies that did not test the peptide alone1

In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Dermorphin.

04AnimalNot a test of Dermorphin aloneAnimal study (in vivo)Mechanism
In squirrel monkeys, naloxone blocked dermorphin-induced response rate increases.
In plain wordsIn squirrel monkeys, naloxone blocked dermorphin-induced increases in responding.
Peptide
Dermorphin
Outcome
Not applicableNaloxone sensitivity of response increases
Study
squirrel monkeyn: not reported in source
Operant responding under food and shock schedules
Outcome group
Locomotor and behavioral activity · Nervous system and cognition
Source sentences
Summary
Dermorphin's rate increases were blocked by the opiate antagonist naloxone, indicating that dermorphin's actions were mediated through the opiate receptor.
1 context sentence(design, population, supporting numbers)
Summary · context
were examined in squirrel monkeys trained to respond under a multiple 3-min fixed-interval schedule of food presentation and either shock presentation or stimulus-shock termination.
In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dermorphin.
Report a problemFND-0257612604

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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