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Study · Animal study (in vivo) · mouse · 1989

2 results

[The effect of prolyl-leucyl-glycine (MIF-1) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on dopamine levels of the striatum].

Sheng JG

Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry1 Aug 1989

PMID2575971 (opens in a new tab)PepBankPUB-02575971
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In MPTP-treated mice, PLG pretreatment preserved higher mean striatal dopamine levels than MPTP alone despite a reduction.

    In plain wordsIn mice given MPTP, PLG pretreatment preserved higher dopamine levels than MPTP alone despite a decrease.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseStriatal dopamine
    Study

    mousen: not reported in source

    MPTP exposure
    Comparator
    MPTP alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the mice pretreated with PLG, although the striatal DA level was also reduced, mean DA and 5-HT levels were significantly higher than in mice given MPTP alone.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In MPTP-treated mice, PLG pretreatment preserved higher mean striatal serotonin levels than MPTP alone.

    In plain wordsIn mice given MPTP, PLG pretreatment preserved higher serotonin levels than MPTP alone.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseStriatal serotonin
    Study

    mousen: not reported in source

    MPTP exposure
    Comparator
    MPTP alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the mice pretreated with PLG, although the striatal DA level was also reduced, mean DA and 5-HT levels were significantly higher than in mice given MPTP alone.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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