MIF-1 is active in a chronic stress animal model of depression.

Pignatiello MF, Olson GA, Kastin AJ, Ehrensing RH, McLean JH, Olson RD

Pharmacology, biochemistry, and behavior1 Mar 1989Cited by 29 (Europe PMC)

PMID2568001DOI10.1016/0091-3057(89)90027-0PepBankPUB-02568001

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In chronically stressed rats, MIF‑1 increased open-field activity on day 21.
In plain wordsIn rats with chronic stress, MIF‑1 increased open-field activity.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseOpen-field activity
Study
ratn: not reported in source
unpredictable chronic stress
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
0.1 mg/kg · intraperitoneal · 20 daysAs given in this study (rat).
Source sentences
Summary
The tricyclic antidepressant imipramine (5 mg/kg) and low doses (0.1 and 1.0 mg/kg) of MIF-1 significantly increased activity and decreased defecation in an open field on day 21.
2 context sentences(design, population, supporting numbers)
Summary · context
MIF-1 was tested in an animal model of depression that used unpredictable chronic stress.
Summary · context
In this paradigm, rats received either no stressors or a daily protocol of a variety of stressors for 20 days, during which time daily, intraperitoneal injections of various compounds were given.
Report a problemFND-0256800101
02AnimalAnimal study (in vivo)Efficacy outcome
In chronically stressed rats, MIF‑1 increased open-field activity on day 21.
In plain wordsIn rats with chronic stress, MIF‑1 increased open-field activity.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseOpen-field activity
Study
ratn: not reported in source
unpredictable chronic stress
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
1.0 mg/kg · intraperitoneal · 20 daysAs given in this study (rat).
Source sentences
Summary
The tricyclic antidepressant imipramine (5 mg/kg) and low doses (0.1 and 1.0 mg/kg) of MIF-1 significantly increased activity and decreased defecation in an open field on day 21.
2 context sentences(design, population, supporting numbers)
Summary · context
MIF-1 was tested in an animal model of depression that used unpredictable chronic stress.
Summary · context
In this paradigm, rats received either no stressors or a daily protocol of a variety of stressors for 20 days, during which time daily, intraperitoneal injections of various compounds were given.
Report a problemFND-0256800102
03AnimalAnimal study (in vivo)Efficacy outcome
In chronically stressed rats, MIF‑1 decreased open-field defecation on day 21.
In plain wordsIn rats with chronic stress, MIF‑1 decreased defecation in an open field.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreaseDefecation
Study
ratn: not reported in source
unpredictable chronic stress
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
0.1 mg/kg · intraperitoneal · 20 daysAs given in this study (rat).
Source sentences
Summary
The tricyclic antidepressant imipramine (5 mg/kg) and low doses (0.1 and 1.0 mg/kg) of MIF-1 significantly increased activity and decreased defecation in an open field on day 21.
2 context sentences(design, population, supporting numbers)
Summary · context
MIF-1 was tested in an animal model of depression that used unpredictable chronic stress.
Summary · context
In this paradigm, rats received either no stressors or a daily protocol of a variety of stressors for 20 days, during which time daily, intraperitoneal injections of various compounds were given.
Report a problemFND-0256800103
04AnimalAnimal study (in vivo)Efficacy outcome
In chronically stressed rats, MIF‑1 decreased open-field defecation on day 21.
In plain wordsIn rats with chronic stress, MIF‑1 decreased defecation in an open field.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
DecreaseDefecation
Study
ratn: not reported in source
unpredictable chronic stress
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
1.0 mg/kg · intraperitoneal · 20 daysAs given in this study (rat).
Source sentences
Summary
The tricyclic antidepressant imipramine (5 mg/kg) and low doses (0.1 and 1.0 mg/kg) of MIF-1 significantly increased activity and decreased defecation in an open field on day 21.
2 context sentences(design, population, supporting numbers)
Summary · context
MIF-1 was tested in an animal model of depression that used unpredictable chronic stress.
Summary · context
In this paradigm, rats received either no stressors or a daily protocol of a variety of stressors for 20 days, during which time daily, intraperitoneal injections of various compounds were given.
Report a problemFND-0256800104
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, high-dose MIF‑1 increased the effects of chronic stress.
In plain wordsIn rats, high-dose MIF‑1 increased the effects of chronic stress.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseChronic stress effects
Study
ratn: not reported in source
unpredictable chronic stress
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
10.0 mg/kg · intraperitoneal · 20 daysAs given in this study (rat).
Source sentences
Summary
A high dose (10.0 mg/kg) of MIF-1 significantly increased the effects of chronic stress and produced hyperalgesia.
2 context sentences(design, population, supporting numbers)
Summary · context
MIF-1 was tested in an animal model of depression that used unpredictable chronic stress.
Summary · context
In this paradigm, rats received either no stressors or a daily protocol of a variety of stressors for 20 days, during which time daily, intraperitoneal injections of various compounds were given.
Report a problemFND-0256800105
06AnimalAnimal study (in vivo)Safety outcome
In chronically stressed rats, high-dose MIF‑1 produced hyperalgesia.
In plain wordsIn rats with chronic stress, high-dose MIF‑1 increased pain sensitivity.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseHyperalgesia
Study
ratn: not reported in source
unpredictable chronic stress
Outcome group
Pain · Nervous system and cognition
Studied dose
10.0 mg/kg · intraperitoneal · 20 daysAs given in this study (rat).
Source sentences
Summary
A high dose (10.0 mg/kg) of MIF-1 significantly increased the effects of chronic stress and produced hyperalgesia.
2 context sentences(design, population, supporting numbers)
Summary · context
MIF-1 was tested in an animal model of depression that used unpredictable chronic stress.
Summary · context
In this paradigm, rats received either no stressors or a daily protocol of a variety of stressors for 20 days, during which time daily, intraperitoneal injections of various compounds were given.
Report a problemFND-0256800106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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