Mechanisms of central hemodynamic and sympathetic regulation by mu opioid receptors: effects of dermorphin in the conscious rat.

Sirén AL, Paakkari P, Goldstein DS, Feuerstein G

The Journal of pharmacology and experimental therapeutics1 Feb 1989Cited by 8 (Europe PMC)

PMID2563768DOI10.1016/s0022-3565(25)23743-0PepBankPUB-02563768

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In conscious rats, dermorphin increased blood pressure.
In plain wordsIn rats, dermorphin increased blood pressure.
Peptide
Dermorphin
Outcome
IncreaseBlood pressure
Study
ratn: not reported in source
Conscious rats
Outcome group
Blood pressure · Cardiovascular
Studied dose
0.1-100 nmol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Dermorphin, at doses of 0.1-100 nmol/kg, increased blood pressure and hindquarter blood flow, renal and mesenteric resistance, and core temperature.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376801
02AnimalAnimal study (in vivo)Activity measurement
In conscious rats, dermorphin increased hindquarter blood flow.
In plain wordsIn rats, dermorphin increased hindquarter blood flow.
Peptide
Dermorphin
Outcome
IncreaseHindquarter blood flow
Study
ratn: not reported in source
Conscious rats
Outcome group
Vascular function · Cardiovascular
Studied dose
0.1-100 nmol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Dermorphin, at doses of 0.1-100 nmol/kg, increased blood pressure and hindquarter blood flow, renal and mesenteric resistance, and core temperature.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376802
03AnimalAnimal study (in vivo)Activity measurement
In conscious rats, dermorphin increased renal vascular resistance.
In plain wordsIn rats, dermorphin increased resistance to blood flow in the kidneys.
Peptide
Dermorphin
Outcome
IncreaseRenal vascular resistance
Study
ratn: not reported in source
Conscious rats
Outcome group
Vascular function · Cardiovascular
Studied dose
0.1-100 nmol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Dermorphin, at doses of 0.1-100 nmol/kg, increased blood pressure and hindquarter blood flow, renal and mesenteric resistance, and core temperature.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376803
04AnimalAnimal study (in vivo)Activity measurement
In conscious rats, dermorphin increased mesenteric vascular resistance.
In plain wordsIn rats, dermorphin increased mesenteric resistance to blood flow.
Peptide
Dermorphin
Outcome
IncreaseMesenteric vascular resistance
Study
ratn: not reported in source
Conscious rats
Outcome group
Vascular function · Cardiovascular
Studied dose
0.1-100 nmol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Dermorphin, at doses of 0.1-100 nmol/kg, increased blood pressure and hindquarter blood flow, renal and mesenteric resistance, and core temperature.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376804
05AnimalAnimal study (in vivo)Activity measurement
In conscious rats, dermorphin increased core temperature.
In plain wordsIn rats, dermorphin increased core temperature.
Peptide
Dermorphin
Outcome
IncreaseCore temperature
Study
ratn: not reported in source
Conscious rats
Outcome group
Body temperature · Whole body
Studied dose
0.1-100 nmol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Dermorphin, at doses of 0.1-100 nmol/kg, increased blood pressure and hindquarter blood flow, renal and mesenteric resistance, and core temperature.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376805
06AnimalAnimal study (in vivo)Safety outcome
In conscious rats, higher dermorphin doses caused respiratory depression.
In plain wordsIn rats, higher dermorphin doses caused respiratory depression.
Peptide
Dermorphin
Outcome
IncreaseRespiratory depression
Study
ratn: not reported in source
Conscious rats
Outcome group
Adverse events · Respiratory
Studied dose
1-5 mumol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Higher doses (1-5 mumol/kg) caused respiratory depression, acidosis, and shock despite profound sympatho-adrenomedullary stimulation.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376806
07AnimalAnimal study (in vivo)Safety outcome
In conscious rats, higher dermorphin doses caused acidosis.
In plain wordsIn rats, higher dermorphin doses caused acidosis.
Peptide
Dermorphin
Outcome
IncreaseAcidosis
Study
ratn: not reported in source
Conscious rats
Outcome group
Adverse events · Whole body
Studied dose
1-5 mumol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Higher doses (1-5 mumol/kg) caused respiratory depression, acidosis, and shock despite profound sympatho-adrenomedullary stimulation.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376807
08AnimalAnimal study (in vivo)Safety outcome
In conscious rats, higher dermorphin doses caused shock despite profound sympatho-adrenomedullary stimulation.
In plain wordsIn rats, higher dermorphin doses caused shock despite strong sympatho-adrenomedullary stimulation.
Peptide
Dermorphin
Outcome
IncreaseShock
Study
ratn: not reported in source
Conscious rats
Outcome group
Adverse events · Cardiovascular
Studied dose
1-5 mumol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Higher doses (1-5 mumol/kg) caused respiratory depression, acidosis, and shock despite profound sympatho-adrenomedullary stimulation.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376808
09AnimalAnimal study (in vivo)Mechanism
In conscious rats, higher dermorphin doses produced profound sympatho-adrenomedullary stimulation.
In plain wordsIn rats, higher dermorphin doses strongly stimulated the sympatho-adrenomedullary system.
Peptide
Dermorphin
Outcome
IncreaseSympatho-adrenomedullary stimulation
Study
ratn: not reported in source
Conscious rats
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1-5 mumol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Higher doses (1-5 mumol/kg) caused respiratory depression, acidosis, and shock despite profound sympatho-adrenomedullary stimulation.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376809
10AnimalAnimal study (in vivo)Activity measurement
In conscious rats, dermorphin significantly increased circulating catecholamine levels.
In plain wordsIn rats, dermorphin significantly increased circulating catecholamine levels.
Peptide
Dermorphin
Outcome
IncreaseCirculating catecholamines
Study
ratn: not reported in source
Conscious rats
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
0.1-100 nmol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Circulating levels of catecholamines were significantly increased at the dermorphin doses of 0.1-100 nmol/kg.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376810
11AnimalAnimal study (in vivo)Activity measurement
In conscious rats, dermorphin increased plasma epinephrine within a reported 2-15-fold range across measured analytes.
In plain wordsIn rats, dermorphin increased plasma epinephrine.
Peptide
Dermorphin
Outcome
IncreasePlasma epinephrine
Study
ratn: not reported in source
Conscious rats
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
100 nmol/kg · intracerebroventricularAs given in this study (rat).
Measurements
Analyte increase range
2 to 15 fold
Range across epinephrine, norepinephrine, DOPAC and 3,4-dihydroxyphenylalanine
Source sentences
Summary
At the 100 nmol/kg dose, plasma levels of epinephrine, norepinephrine, the dopamine metabolite dihydroxyphenylacetic acid and the catecholamine precursor 3,4-dihydroxyphenylalanine were increased by 2-15-fold.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376811
12AnimalAnimal study (in vivo)Activity measurement
In conscious rats, dermorphin increased plasma norepinephrine within a reported 2-15-fold range across measured analytes.
In plain wordsIn rats, dermorphin increased plasma norepinephrine.
Peptide
Dermorphin
Outcome
IncreasePlasma norepinephrine
Study
ratn: not reported in source
Conscious rats
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
100 nmol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
At the 100 nmol/kg dose, plasma levels of epinephrine, norepinephrine, the dopamine metabolite dihydroxyphenylacetic acid and the catecholamine precursor 3,4-dihydroxyphenylalanine were increased by 2-15-fold.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376812
13AnimalAnimal study (in vivo)Activity measurement
In conscious rats, dermorphin increased plasma dihydroxyphenylacetic acid within a reported 2-15-fold range across measured analytes.
In plain wordsIn rats, dermorphin increased plasma dihydroxyphenylacetic acid.
Peptide
Dermorphin
Outcome
IncreasePlasma dihydroxyphenylacetic acid
Study
ratn: not reported in source
Conscious rats
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
100 nmol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
At the 100 nmol/kg dose, plasma levels of epinephrine, norepinephrine, the dopamine metabolite dihydroxyphenylacetic acid and the catecholamine precursor 3,4-dihydroxyphenylalanine were increased by 2-15-fold.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376813
14AnimalAnimal study (in vivo)Activity measurement
In conscious rats, dermorphin increased plasma 3,4-dihydroxyphenylalanine within a reported 2-15-fold range across measured analytes.
In plain wordsIn rats, dermorphin increased plasma 3,4-dihydroxyphenylalanine.
Peptide
Dermorphin
Outcome
IncreasePlasma 3,4-dihydroxyphenylalanine
Study
ratn: not reported in source
Conscious rats
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
100 nmol/kg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
At the 100 nmol/kg dose, plasma levels of epinephrine, norepinephrine, the dopamine metabolite dihydroxyphenylacetic acid and the catecholamine precursor 3,4-dihydroxyphenylalanine were increased by 2-15-fold.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of i.c.v. administered dermorphin, a highly selective mu-opioid agonist, on cardiac function and renal, mesenteric and hindquarter blood flow were studied in conscious rats.
Report a problemFND-0256376814

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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