Immunoreactive delta sleep-inducing peptide secretion from mouse dissociated, anterior pituitary cells: regulation by corticotropin-releasing factor and arginine vasopressin.

Bjartell A, Castro MG, Ekman R, Sundler F, Widerlöv E, Loh YP

Neuroendocrinology1 Nov 1989Cited by 11 (Europe PMC)

PMID2558325DOI10.1159/000125282PepBankPUB-02558325

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In dissociated mouse anterior pituitary cells, synthetic DSIP at or above 10(-9) M inhibited basal immunoreactive ACTH release.
In plain wordsIn mouse pituitary cells in lab tests, DSIP lowered the release of ACTH.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseBasal IR-ACTH release
Study
mousen: not reported in source
Dissociated mouse anterior pituitary cells
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
>= 10(-9) MAs given in this study (mouse).
Source sentences
Summary
DSIP (greater than or equal to 10(-9) M) inhibited both basal
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic DSIP on IR-ACTH release from dissociated mouse anterior pituitary cells was also studied.
Report a problemFND-0255832502
02LabIn vitro (cells)Efficacy outcome
In dissociated mouse anterior pituitary cells, synthetic DSIP at or above 10(-9) M inhibited CRF-induced immunoreactive ACTH release.
In plain wordsIn mouse pituitary cells in lab tests, DSIP reduced the ACTH release that CRF had triggered.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseCRF-induced IR-ACTH release
Study
mousen: not reported in source
Dissociated mouse anterior pituitary cells
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
>= 10(-9) MAs given in this study (mouse).
Source sentences
Summary
DSIP (greater than or equal to 10(-9) M) inhibited both basal and CRF-induced IR-ACTH release from these cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic DSIP on IR-ACTH release from dissociated mouse anterior pituitary cells was also studied.
Report a problemFND-0255832503

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

03LabEndogenous levelEx vivo tissueOther
In the mouse pituitary, immunoreactive DSIP was co-localized with TSH in anterior pituitary thyrotrophs and was present in nerve fibers of the posterior and intermediate lobes.
In plain wordsIn mouse pituitary tissue, the body's own DSIP-like material was found in thyroid-stimulating cells and in nerve fibres.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableIR-DSIP localization in mouse pituitary
Study
mousen: not reported in source
Mouse pituitary gland (immunocytochemistry)
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In this species, IR-DSIP was found to be co-localized with thyroid-stimulating hormone (TSH) in anterior pituitary thyrotrophs and was also present in nerve fibers in the posterior and intermediate lobes.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0255832501
04LabEndogenous levelIn vitro (cells)Other
In dissociated mouse anterior pituitary cells, CRF and AVP inhibited release of immunoreactive DSIP by 63%.
In plain wordsIn mouse pituitary cells in lab tests, CRF and AVP lowered release of the cells' own DSIP.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseIR-DSIP release after CRF and AVP
Study
mousen: not reported in source
Dissociated mouse anterior pituitary cells
Outcome group
Pituitary hormones · Endocrine and hormones
Measurements
Inhibition of IR-DSIP release
63%
CRF and AVP
Source sentences
Summary
CRF and AVP at concentrations of 10(-11)-10(-7)M inhibited release of IR-DSIP from mouse anterior pituitary cells by 63%.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0255832504
05LabEndogenous levelIn vitro (cells)Other
In dissociated mouse anterior pituitary cells, CRF and AVP given together showed no additive effect on immunoreactive DSIP secretion.
In plain wordsIn mouse pituitary cells in lab tests, CRF and AVP together did not lower the cells' own DSIP release more than each alone.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
No significant changeIR-DSIP release after concomitant CRF and AVP
Study
mousen: not reported in source
Dissociated mouse anterior pituitary cells
Outcome group
Pituitary hormones · Endocrine and hormones
Source sentences
Summary
When CRF and AVP (10(-10)-10(-7) M) were given concomitantly, the maximal inhibition of IR-DSIP release was observed at a concentration of 10(-8)M of CRF and AVP. However, these two peptides when given together showed no additive effect on IR-DSIP secretion.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0255832505

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.