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Study · Non-randomized trial · n = 7 · 1989

5 results

Effects of intranasal calcitonin administration on pituitary GH response to hGHRH (1-29)NH2 in normal adult subjects.

Giustina A, Romanelli G, Doga M, Pizzocolo G, Giustina G

Clinical endocrinology1 Jun 1989Cited by 8 (Europe PMC)

PMID2556224 (opens in a new tab)DOI10.1111/j.1365-2265.1989.tb00276.x (opens in a new tab)PepBankPUB-02556224
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy volunteers, a 100 microgram IV bolus of GHRH(1-29)NH2 alone produced a mean GH peak of 22.9 micrograms/l.

    In plain wordsIn healthy volunteers, a single GHRH injection into a vein produced a clear growth hormone peak.

    Peptide
    Sermorelin
    Outcome
    IncreaseGH peak after GHRH alone
    Study

    n = 7

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms · intravenous · single bolusAs given in this study (human).

    Measurements

    GH peak
    22.9 micrograms/l
    GHRH alone

    Source sentences

    Summary
    GHRH alone 22.9 +/- 2.5 vs
    1 context sentence
    Summary · context
    Seven healthy non-obese volunteers (five men, two women; mean age +/- SDM 25 +/- 2) underwent a bolus intravenous injection of GHRH, 100 micrograms, alone or associated with sCT, administered either i.n., 300 IU, or i.m., 100 IU.

Studies that did not test the peptide alone4

In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Sermorelin.

  1. 02HumanNot a test of Sermorelin aloneNon-randomized trialMechanism

    In healthy volunteers, intranasal salmon calcitonin reduced the GH peak after GHRH from 22.9 to 8.9 micrograms/l (P less than 0.001).

    In plain wordsIn healthy volunteers, calcitonin sprayed in the nose lowered the growth hormone peak after GHRH compared with GHRH alone.

    Peptide
    Sermorelin
    Outcome
    DecreaseGH peak after GHRH with intranasal calcitonin
    Study

    n = 7

    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH peak
    22.9 micrograms/l
    GHRH alone
    GH peak
    8.9 micrograms/l
    GHRH plus i.n. sCT

    Source sentences

    Summary
    GH peak (mean +/- SDM); GHRH alone 22.9 +/- 2.5 vs GHRH plus i.n. sCT, 8.9 +/- 1.5 micrograms/l, P less than 0.001; or vs GHRH plus i.m. sCT 12.3 +/- 2.5 micrograms/l, P less than 0.001.
    1 context sentence
    Summary · context
    Seven healthy non-obese volunteers (five men, two women; mean age +/- SDM 25 +/- 2) underwent a bolus intravenous injection of GHRH, 100 micrograms, alone or associated with sCT, administered either i.n., 300 IU, or i.m., 100 IU.

    In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.

  2. 03HumanNot a test of Sermorelin aloneNon-randomized trialMechanism

    In healthy volunteers, intramuscular salmon calcitonin reduced the GH peak after GHRH from 22.9 to 12.3 micrograms/l (P less than 0.001).

    In plain wordsIn healthy volunteers, calcitonin injected into muscle lowered the growth hormone peak after GHRH compared with GHRH alone.

    Peptide
    Sermorelin
    Outcome
    DecreaseGH peak after GHRH with intramuscular calcitonin
    Study

    n = 7

    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH peak
    22.9 micrograms/l
    GHRH alone
    GH peak
    12.3 micrograms/l
    GHRH plus i.m. sCT

    Source sentences

    Summary
    GH peak (mean +/- SDM); GHRH alone 22.9 +/- 2.5 vs GHRH plus i.n. sCT, 8.9 +/- 1.5 micrograms/l, P less than 0.001; or vs GHRH plus i.m. sCT 12.3 +/- 2.5 micrograms/l, P less than 0.001.
    1 context sentence
    Summary · context
    Seven healthy non-obese volunteers (five men, two women; mean age +/- SDM 25 +/- 2) underwent a bolus intravenous injection of GHRH, 100 micrograms, alone or associated with sCT, administered either i.n., 300 IU, or i.m., 100 IU.

    In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.

  3. 04HumanNot a test of Sermorelin aloneNon-randomized trialMechanism

    In healthy volunteers, intranasal salmon calcitonin reduced the GH area under the curve after GHRH from 1211 to 551 micrograms 120 min/l.

    In plain wordsIn healthy volunteers, calcitonin sprayed in the nose lowered the total growth hormone response to GHRH compared with GHRH alone.

    Peptide
    Sermorelin
    Outcome
    DecreaseGH area under the curve after GHRH with intranasal calcitonin
    Study

    n = 7

    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH AUC
    1211 micrograms 120 min/l
    GHRH alone
    GH AUC
    551 micrograms 120 min/l
    GHRH plus i.n. sCT

    Source sentences

    Summary
    Area under the curve of GH secretion: GHRH alone 1211 +/- 196 vs GHRH plus i.n. sCT 551 +/- 116 micrograms 120 min/l.
    2 context sentences
    Summary · context
    P less than 0.001; or vs GHRH plus i.m. sCT 700 +/- 167 micrograms 120 min/l, P less than 0.001.
    Summary · context
    Seven healthy non-obese volunteers (five men, two women; mean age +/- SDM 25 +/- 2) underwent a bolus intravenous injection of GHRH, 100 micrograms, alone or associated with sCT, administered either i.n., 300 IU, or i.m., 100 IU.

    In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.

  4. 05HumanNot a test of Sermorelin aloneNon-randomized trialMechanism

    In healthy volunteers, intramuscular salmon calcitonin reduced the GH area under the curve after GHRH to 700 micrograms 120 min/l (P less than 0.001).

    In plain wordsIn healthy volunteers, calcitonin injected into muscle lowered the total growth hormone response to GHRH compared with GHRH alone.

    Peptide
    Sermorelin
    Outcome
    DecreaseGH area under the curve after GHRH with intramuscular calcitonin
    Study

    n = 7

    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH AUC
    700 micrograms 120 min/l
    GHRH plus i.m. sCT

    Source sentences

    Summary
    P less than 0.001; or vs GHRH plus i.m. sCT 700 +/- 167 micrograms 120 min/l, P less than 0.001.
    1 context sentence
    Summary · context
    Seven healthy non-obese volunteers (five men, two women; mean age +/- SDM 25 +/- 2) underwent a bolus intravenous injection of GHRH, 100 micrograms, alone or associated with sCT, administered either i.n., 300 IU, or i.m., 100 IU.

    In this study, Sermorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Sermorelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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