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Study · Non-randomized trial · n = 8 · 1989

5 results

Adrenocorticotropin stimulation of aldosterone: prolonged continuous versus pulsatile infusion.

Seely EW, Conlin PR, Brent GA, Dluhy RG

The Journal of clinical endocrinology and metabolism1 Nov 1989Cited by 30 (Europe PMC)

PMID2551915 (opens in a new tab)DOI10.1210/jcem-69-5-1028 (opens in a new tab)PepBankPUB-02551915
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In normal men, sodium, potassium, plasma renin activity, angiotensin-II and cortisol did not differ significantly between pulsatile and continuous cosyntropin infusions.

    In plain wordsIn normal men, sodium, potassium, renin activity, angiotensin-II and cortisol did not differ significantly between pulsatile and continuous cosyntropin infusions.

    Peptide
    Cosyntropin
    Outcome
    No significant changeSodium, potassium, renin activity, angiotensin-II and cortisol
    Study

    n = 8

    Comparator
    Continuous cosyntropin infusion
    Outcome group
    Adrenal Response · Endocrine and hormones
    Studied dose
    4 U/24 h · intravenous · 48 or 72 hAs given in this study (human).

    Source sentences

    Summary
    There were no significant differences in sodium, potassium, PRA, angiotensin-II, or cortisol between infusions to explain these differences in aldosterone levels.
    3 context sentences
    Summary · context
    Since CRH and ACTH are released in a pulsatile pattern in man, this study sought to investigate whether pulsatile administration of alpha-cosyntropin-(1-24) would lead to the maintenance of aldosterone stimulation over time.
    Summary · context
    Eight normal male subjects on a 10-meq sodium, 100-meq potassium diet received both a continuous and a pulsatile (0.33 U ACTH/pulse over 15 min, pulsed every 2 h) infusion of cosyntropin (4 U/24 h) for 48 h (n = 4) or 72 h (n = 4).
    Summary · context
    Aldosterone and cortisol were sampled every 6 h, and PRA and angiotensin-II every 24 h.
  2. 02HumanNon-randomized trialActivity measurement

    In normal men, aldosterone after continuous cosyntropin returned to preinfusion levels by 72 h.

    In plain wordsIn normal men, aldosterone after continuous cosyntropin returned to its starting level by 72 h.

    Peptide
    Cosyntropin
    Outcome
    No significant changeAldosterone after continuous infusion
    Study

    n = 4

    Comparator
    Preinfusion
    Outcome group
    Adrenal Response · Endocrine and hormones
    Studied dose
    4 U/24 h · intravenous · 48 or 72 hAs given in this study (human).

    Measurements

    Aldosterone
    29 ng/dL
    preinfusion mean +/- 5
    Aldosterone
    810 pmol/L
    preinfusion mean +/- 139
    Aldosterone
    38 ng/dL
    72 h mean +/- 10
    Aldosterone
    1054 pmol/L
    72 h mean +/- 277
    P
    0.4
    baseline comparison

    Source sentences

    Summary
    Continuous infusion led to a stimulation of aldosterone followed by a progressive decline to preinfusion levels by 72 h [preinfusion 29 +/- 5 ng/dL (810 +/- 139 pmol/L); 72 h, 38 +/- 10 ng/dL (1054 +/- 277 pmol/L); P = 0.40].
    3 context sentences
    Summary · context
    Since CRH and ACTH are released in a pulsatile pattern in man, this study sought to investigate whether pulsatile administration of alpha-cosyntropin-(1-24) would lead to the maintenance of aldosterone stimulation over time.
    Summary · context
    Eight normal male subjects on a 10-meq sodium, 100-meq potassium diet received both a continuous and a pulsatile (0.33 U ACTH/pulse over 15 min, pulsed every 2 h) infusion of cosyntropin (4 U/24 h) for 48 h (n = 4) or 72 h (n = 4).
    Summary · context
    Aldosterone and cortisol were sampled every 6 h, and PRA and angiotensin-II every 24 h.
  3. 03HumanNon-randomized trialActivity measurement

    In normal men, pulsatile cosyntropin maintained elevated aldosterone through 72 h.

    In plain wordsIn normal men, pulsatile cosyntropin kept aldosterone above its starting level through 72 h.

    Peptide
    Cosyntropin
    Outcome
    IncreaseAldosterone after pulsatile infusion
    Study

    n = 4

    Comparator
    Preinfusion
    Outcome group
    Adrenal Response · Endocrine and hormones
    Studied dose
    4 U/24 h · intravenous · 48 or 72 hAs given in this study (human).

    Measurements

    Aldosterone
    33 ng/dL
    preinfusion mean +/- 7
    Aldosterone
    915 pmol/L
    preinfusion mean +/- 194
    Aldosterone
    85 ng/dL
    72 h mean +/- 13
    Aldosterone
    2358 pmol/L
    72 h mean +/- 361
    P
    < 0.05
    baseline comparison

    Source sentences

    Summary
    Pulsatile infusion led to a stimulation of aldosterone which was maintained up to 72 h [preinfusion 33 +/- 7 ng/dL (915 +/- 194 pmol/L); 72 h, 85 +/- 13 ng/dL (2358 +/- 361 pmol/L); P less than 0.05].
    3 context sentences
    Summary · context
    Since CRH and ACTH are released in a pulsatile pattern in man, this study sought to investigate whether pulsatile administration of alpha-cosyntropin-(1-24) would lead to the maintenance of aldosterone stimulation over time.
    Summary · context
    Eight normal male subjects on a 10-meq sodium, 100-meq potassium diet received both a continuous and a pulsatile (0.33 U ACTH/pulse over 15 min, pulsed every 2 h) infusion of cosyntropin (4 U/24 h) for 48 h (n = 4) or 72 h (n = 4).
    Summary · context
    Aldosterone and cortisol were sampled every 6 h, and PRA and angiotensin-II every 24 h.
  4. 04HumanNon-randomized trialActivity measurement

    In normal men, aldosterone declined progressively from its peak at 18 h during continuous cosyntropin infusion.

    In plain wordsIn normal men, aldosterone declined from its peak at 18 h during continuous cosyntropin infusion.

    Peptide
    Cosyntropin
    Outcome
    DecreaseAldosterone time trend during continuous infusion
    Study

    n: not reported in source

    Outcome group
    Adrenal Response · Endocrine and hormones
    Studied dose
    4 U/24 h · intravenous · 48 or 72 hAs given in this study (human).

    Measurements

    Correlation
    0.63 r
    time trend
    P
    0.001
    regression

    Source sentences

    Summary
    Regression analysis of aldosterone (y) over time (x) from the peak level at 18 h for the continuous infusion showed a significant negative relation (r = 0.63; P = 0.001), indicating a progressive decline in aldosterone.
    3 context sentences
    Summary · context
    Since CRH and ACTH are released in a pulsatile pattern in man, this study sought to investigate whether pulsatile administration of alpha-cosyntropin-(1-24) would lead to the maintenance of aldosterone stimulation over time.
    Summary · context
    Eight normal male subjects on a 10-meq sodium, 100-meq potassium diet received both a continuous and a pulsatile (0.33 U ACTH/pulse over 15 min, pulsed every 2 h) infusion of cosyntropin (4 U/24 h) for 48 h (n = 4) or 72 h (n = 4).
    Summary · context
    Aldosterone and cortisol were sampled every 6 h, and PRA and angiotensin-II every 24 h.
  5. 05HumanNon-randomized trialActivity measurement

    In normal men, aldosterone showed no time relationship during pulsatile cosyntropin infusion, indicating maintained levels.

    In plain wordsIn normal men, aldosterone levels stayed stable during pulsatile cosyntropin infusion.

    Peptide
    Cosyntropin
    Outcome
    No significant changeAldosterone time trend during pulsatile infusion
    Study

    n: not reported in source

    Outcome group
    Adrenal Response · Endocrine and hormones
    Studied dose
    4 U/24 h · intravenous · 48 or 72 hAs given in this study (human).

    Measurements

    Correlation
    0.02 r
    time trend
    P
    0.85
    regression

    Source sentences

    Summary
    However, for the pulsatile infusion, there was no relation (r = 0.02; P = 0.85), indicating maintenance of aldosterone levels.
    3 context sentences
    Summary · context
    Since CRH and ACTH are released in a pulsatile pattern in man, this study sought to investigate whether pulsatile administration of alpha-cosyntropin-(1-24) would lead to the maintenance of aldosterone stimulation over time.
    Summary · context
    Eight normal male subjects on a 10-meq sodium, 100-meq potassium diet received both a continuous and a pulsatile (0.33 U ACTH/pulse over 15 min, pulsed every 2 h) infusion of cosyntropin (4 U/24 h) for 48 h (n = 4) or 72 h (n = 4).
    Summary · context
    Aldosterone and cortisol were sampled every 6 h, and PRA and angiotensin-II every 24 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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