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Study · Not a test of the peptide alone · 1989

5 results

Ontogeny of vasopressin and oxytocin binding sites in the brain of Wistar and Brattleboro rats as demonstrated by lightmicroscopical autoradiography.

Snijdewint FG, Van Leeuwen FW, Boer GJ

Journal of chemical neuroanatomy1 Jan 1989Cited by 43 (Europe PMC)

PMID2551339 (opens in a new tab)PepBankPUB-02551339
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    This study shows oxytocin binding sites in the developing rat brain for the first time.

    In plain wordsIn rat brain tissue, oxytocin binding sites were shown for the first time in the developing brain.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin binding sites in the developing brain
    Study

    ratn: not reported in source

    Brain tissue sections
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    This study shows, for the first time, OT binding sites in the developing rat brain.
    1 context sentence
    Summary · context
    Vasopressin (VP) and oxytocin (OT) binding sites were localized and quantified in the developing brain of the Wistar, heterozygous (Het) and homozygous (Hom) VP-deficient Brattleboro rat using an autoradiographical technique.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In the developing rat brain, oxytocin binding overlapped considerably with vasopressin binding, sometimes with the same developmental pattern and sometimes with a later appearance.

    In plain wordsIn developing rat brain tissue, oxytocin and vasopressin binding sites often occurred in the same areas, sometimes later for oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableOverlap of oxytocin and vasopressin binding
    Study

    ratn: not reported in source

    Brain tissue sections
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    There is a considerable overlap with VP binding in the brain, sometimes with the same developmental pattern, e.g. in the anterior olfactory nucleus and caudate putamen and sometimes with a later appearance, e.g. in the central amygdala and thalamic nuclei.
    1 context sentence
    Summary · context
    Vasopressin (VP) and oxytocin (OT) binding sites were localized and quantified in the developing brain of the Wistar, heterozygous (Het) and homozygous (Hom) VP-deficient Brattleboro rat using an autoradiographical technique.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In the developing rat brain, most areas with vasopressin binding sites did not show oxytocin binding.

    In plain wordsIn developing rat brain tissue, most areas with vasopressin binding sites had no oxytocin binding.

    Peptide
    Oxytocin
    Outcome
    No significant changeAreas with vasopressin binding but without oxytocin binding
    Study

    ratn: not reported in source

    Brain tissue sections
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    However most areas with VP binding sites did not show OT binding.
    1 context sentence
    Summary · context
    Vasopressin (VP) and oxytocin (OT) binding sites were localized and quantified in the developing brain of the Wistar, heterozygous (Het) and homozygous (Hom) VP-deficient Brattleboro rat using an autoradiographical technique.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In the developing rat brain, only oxytocin binding sites were present in some areas, for example the islands of Calleja and the ventromedial hypothalamus.

    In plain wordsIn developing rat brain tissue, some areas had oxytocin binding sites but no vasopressin binding sites.

    Peptide
    Oxytocin
    Outcome
    Not applicableAreas with only oxytocin binding
    Study

    ratn: not reported in source

    Brain tissue sections
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In some areas only OT binding sites were present, for instance in the islands of Calleja and ventromedial hypothalamus.
    1 context sentence
    Summary · context
    Vasopressin (VP) and oxytocin (OT) binding sites were localized and quantified in the developing brain of the Wistar, heterozygous (Het) and homozygous (Hom) VP-deficient Brattleboro rat using an autoradiographical technique.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  5. 05LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In the developing rat brain, oxytocin binding decreased between postnatal days 5 and 15 in the dorsal hippocampus and disappeared completely in the parietal cortex.

    In plain wordsIn rat brain tissue, oxytocin binding sites declined as the rats grew and vanished from one cortex region.

    Peptide
    Oxytocin
    Outcome
    DecreaseDecline of oxytocin binding between PN5 and PN15
    Study

    ratn: not reported in source

    Brain tissue sections
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Similar to some areas with VP binding, OT binding decreased between postnatal day 5 and 15 in the dorsal hippocampus and even completely disappeared in the parietal cortex.
    1 context sentence
    Summary · context
    Vasopressin (VP) and oxytocin (OT) binding sites were localized and quantified in the developing brain of the Wistar, heterozygous (Het) and homozygous (Hom) VP-deficient Brattleboro rat using an autoradiographical technique.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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