Skip to content

Study · Not a test of the peptide alone · 1989

5 results

Characterization of oxytocin receptors in rat adenohypophysis using a radioiodinated receptor antagonist peptide.

Chadio SE, Antoni FA

The Journal of endocrinology1 Aug 1989Cited by 17 (Europe PMC)

PMID2549159 (opens in a new tab)DOI10.1677/joe.0.1220465 (opens in a new tab)PepBankPUB-02549159
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In rat uterine and pituitary membranes, a radioiodinated oxytocin antagonist bound reversibly and with high affinity to a single class of sites.

    In plain wordsIn rat uterus and pituitary membranes, a labelled oxytocin blocker bound tightly to one type of receptor site.

    Peptide
    Oxytocin
    Outcome
    Not applicableAffinity of radioiodinated oxytocin antagonist binding
    Study

    ratn = 3

    Uterine and adenohypophysial membrane suspensions
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Measurements

    Kd
    0.2 nmol/l
    uterus
    Kd
    0.1 nmol/l
    adenohypophysis

    Source sentences

    Summary
    In uterine as well as the pituitary membrane suspensions, the radioligand was bound reversibly and with high affinity (dissociation constants 0.2 +/- 0.1 and 0.1 +/- 0.01 nmol/l respectively; mean +/- S.E.M., n = 3) to a single class of sites with limited binding capacity, which varied with the type of pretreatment.
    1 context sentence
    Summary · context
    In the present study we have investigated the properties of putative oxytocin receptors in the rat adenohypophysis by radioligand-binding assay.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In ovariectomized rats, oestradiol-17 beta increased the oxytocin antagonist binding capacity fivefold in the uterus.

    In plain wordsIn rats, oestradiol raised the number of oxytocin receptors in the uterus about fivefold.

    Peptide
    Oxytocin
    Outcome
    IncreaseBinding capacity in uterus after oestradiol
    Study

    ratn: not reported in source

    Uterine and adenohypophysial membrane suspensions
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Oestradiol-17 beta increased the binding capacity fivefold in the uterus in ovariectomized rats
    1 context sentence
    Summary · context
    In the present study we have investigated the properties of putative oxytocin receptors in the rat adenohypophysis by radioligand-binding assay.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In ovariectomized rats given oestradiol-17 beta, only very low specific radioligand binding was found in pituitary preparations.

    In plain wordsIn rats given oestradiol, the pituitary showed only very low oxytocin receptor binding.

    Peptide
    Oxytocin
    Outcome
    No significant changeBinding capacity in pituitary after oestradiol
    Study

    ratn: not reported in source

    Uterine and adenohypophysial membrane suspensions
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    but only very low specific radioligand binding was found in pituitary preparations from the same animals.
    1 context sentence
    Summary · context
    In the present study we have investigated the properties of putative oxytocin receptors in the rat adenohypophysis by radioligand-binding assay.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In rats, diethylstilboestrol treatment markedly increased the number of oxytocin receptors in both the uterus and the adenohypophysis.

    In plain wordsIn rats, diethylstilboestrol clearly raised the number of oxytocin receptors in both uterus and pituitary.

    Peptide
    Oxytocin
    Outcome
    IncreaseReceptor number after diethylstilboestrol
    Study

    ratn: not reported in source

    Uterine and adenohypophysial membrane suspensions
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Treatment with DES markedly increased the number of receptors in both the uterus and the adenohypophysis.
    1 context sentence
    Summary · context
    In the present study we have investigated the properties of putative oxytocin receptors in the rat adenohypophysis by radioligand-binding assay.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  5. 05LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In rat tissue, several agonist and antagonist analogues showed no difference in ligand specificity between the uterine and adenohypophysial binding sites.

    In plain wordsIn rat tissue, the uterus and pituitary binding sites reacted to the same compounds, so they appear to be the same receptor.

    Peptide
    Oxytocin
    Outcome
    No significant changeLigand specificity of uterine and adenohypophysial sites
    Study

    ratn: not reported in source

    Uterine and adenohypophysial membrane suspensions
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Studies with several agonist and antagonist analogues revealed no difference in the ligand specificity of the uterine and adenohypophysial sites binding 125I-OTA, indicating that they are the same species of receptor
    1 context sentence
    Summary · context
    In the present study we have investigated the properties of putative oxytocin receptors in the rat adenohypophysis by radioligand-binding assay.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.