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Study · Non-randomized trial · n = 36 · 1989

3 results

Growth hormone (GH) release after administration of GH-releasing hormone in relation to endogenous 24-h GH secretion in short children.

Gelander L, Albertsson-Wikland K

The Journal of endocrinology1 Jul 1989Cited by 9 (Europe PMC)

PMID2549156 (opens in a new tab)DOI10.1677/joe.0.1220061 (opens in a new tab)PepBankPUB-02549156
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialOther

    In 36 short children, the maximal GH response to GHRH(1-29)-NH2 varied widely, from 5 to 296 mU/l.

    In plain wordsIn 36 short children, the growth hormone response to GHRH varied widely between children.

    Peptide
    Sermorelin
    Outcome
    Not applicableMaximal GH response to GHRH
    Study

    n = 36

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg · intravenous · single injectionAs given in this study (human).

    Measurements

    Maximal GH response
    5 to 296 mU/l
    after GHRH

    Source sentences

    Summary
    A high variability was found both in the 24-h GH secretion expressed as area under the curve above the baseline (0-1588 mU/l x 24 h) and the maximal GH response to GHRH (5-296 mU/l)
    2 context sentences
    Summary · context
    Endogenous GH secretion was measured every 20 min for 24 h in 36 short children.
    Summary · context
    This was immediately followed by an i.v. injection of GH-releasing hormone (GHRH)(1-29)-NH2 (1 microgram/kg), and GH was estimated every 15 min for the following 2 h.
  2. 02HumanNon-randomized trialOther

    In short children, the GH response to GHRH correlated positively with spontaneous 24-h GH secretion (rs = 0.49; P less than 0.01).

    In plain wordsIn short children, a larger growth hormone response to GHRH was linked to higher natural growth hormone release over 24 hours.

    Peptide
    Sermorelin
    Outcome
    IncreaseCorrelation of GHRH-induced GH response with 24-h spontaneous GH secretion
    Study

    n = 36

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg · intravenous · single injectionAs given in this study (human).

    Measurements

    Spearman rs
    0.49
    GH response to GHRH vs 24-h GH secretion

    Source sentences

    Summary
    We found a positive correlation (correlation coefficient of Spearman (rs) = 0.49; P less than 0.01) between the GH response to GHRH and the spontaneous GH secretion over a 24-h period
    2 context sentences
    Summary · context
    Endogenous GH secretion was measured every 20 min for 24 h in 36 short children.
    Summary · context
    This was immediately followed by an i.v. injection of GH-releasing hormone (GHRH)(1-29)-NH2 (1 microgram/kg), and GH was estimated every 15 min for the following 2 h.
  3. 03HumanNon-randomized trialOther

    In short children, the GH response to GHRH correlated negatively with GH secretion during the preceding 3 h (rs = -0.80; P less than 0.01).

    In plain wordsIn short children, a larger growth hormone response to GHRH was linked to less natural growth hormone release in the 3 hours before.

    Peptide
    Sermorelin
    Outcome
    DecreaseCorrelation of GHRH-induced GH response with GH secretion in preceding 3 h
    Study

    n = 36

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg · intravenous · single injectionAs given in this study (human).

    Measurements

    Spearman rs
    −0.8
    GH response to GHRH vs GH secretion in preceding 3 h

    Source sentences

    Summary
    in spite of a negative correlation (rs = -0.80; P less than 0.01) with the GH secretion during the preceding 3 h.
    2 context sentences
    Summary · context
    Endogenous GH secretion was measured every 20 min for 24 h in 36 short children.
    Summary · context
    This was immediately followed by an i.v. injection of GH-releasing hormone (GHRH)(1-29)-NH2 (1 microgram/kg), and GH was estimated every 15 min for the following 2 h.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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