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Study · Animal study (in vivo) · rat · 1989

4 results

[Comparison of the effects of thyroliberin and ACTH4-7 PGP on the learning of rats during the solving of spatial orientation tasks].

Chepurnova NE, Guseva AA, Efimova EV, Mart'ianov AA, Chepurnov SA

Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova1 May 1989Cited by 1 (Europe PMC)

PMID2548895 (opens in a new tab)PepBankPUB-02548895
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, ACTH4-7 Pro-Gly-Pro (semax) accelerated spatial learning on the 12-arm radial maze and the T-maze.

    In plain wordsIn rats, ACTH4-7 Pro-Gly-Pro (semax) sped up spatial learning in two mazes.

    Peptide
    Semax
    Outcome
    IncreaseSpatial learning on the 12-arm radial maze and T-maze
    Study

    ratn: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    15 and 25 micrograms/kgAs given in this study (rat).

    Source sentences

    Summary
    The influence of TRH (100 micrograms/kg) and ACTH4-7 Pro-Gly-Pro (15 micrograms/kg and 25 micrograms/kg) involved an acceleration of the spatial learning on the 12-arm radial maze and on T-maze in rats
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, ACTH4-7 Pro-Gly-Pro (semax) increased the number of correct choices after a short retention interval.

    In plain wordsIn rats, ACTH4-7 Pro-Gly-Pro (semax) increased correct choices after a short wait.

    Peptide
    Semax
    Outcome
    IncreaseCorrect choices after a short retention interval
    Study

    ratn: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    15 and 25 micrograms/kgAs given in this study (rat).

    Source sentences

    Summary
    an increase in the number of correct choice after short (5-10 min) retention interval
    1 context sentence
    Summary · context
    The influence of TRH (100 micrograms/kg) and ACTH4-7 Pro-Gly-Pro (15 micrograms/kg and 25 micrograms/kg)
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, ACTH4-7 Pro-Gly-Pro (semax) affected working and reference spatial memory in the reinforced place performance test. The abstract gives no direction.

    In plain wordsIn rats, ACTH4-7 Pro-Gly-Pro (semax) affected spatial memory in a place test. The direction is not stated.

    Peptide
    Semax
    Outcome
    Direction not reportedWorking and reference spatial memory
    Study

    ratn: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    15 and 25 micrograms/kgAs given in this study (rat).

    Source sentences

    Summary
    and affected the working and reference spatial memory in the test of reinforced place performance.
    1 context sentence
    Summary · context
    The influence of TRH (100 micrograms/kg) and ACTH4-7 Pro-Gly-Pro (15 micrograms/kg and 25 micrograms/kg)

Studies that did not test the peptide alone1

In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Semax.

  1. 04AnimalNot a test of Semax aloneAnimal study (in vivo)Other

    In rats, the effects of TRH and ACTH4-7 Pro-Gly-Pro (semax) did not interfere with one another.

    In plain wordsIn rats, the effects of TRH and ACTH4-7 Pro-Gly-Pro (semax) did not interfere with each other.

    Peptide
    Semax
    Outcome
    No significant changeInteraction between TRH and ACTH4-7 Pro-Gly-Pro effects
    Study

    ratn: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    The effects of the TRH and ACTH4-7 Pro-Gly-Pro did not interfere with one another.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:40 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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