Skip to content

Study · In vitro (cells) · mouse · 1989

4 results

Homologous and heterologous regulation of the helodermin/vasoactive-intestinal-peptide response in the murine radiation leukemia-virus-induced lymphoma cell line BL/VL3.

Abello J, Damien C, Robberecht P, Hooghe R, Vandermeers A, Vandermeers-Piret MC, Christophe J

European journal of biochemistry1 Aug 1989Cited by 8 (Europe PMC)

PMID2547607 (opens in a new tab)DOI10.1111/j.1432-1033.1989.tb14923.x (opens in a new tab)PepBankPUB-02547607
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In BL/VL3 cells, short-term (5-30 min) exposure to VIP induced both homologous and heterologous desensitization.

    In plain wordsIn mouse lymphoma cells, short exposure to VIP made the cells respond less to VIP and to other signals.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseDesensitization after short-term VIP exposure
    Study

    mousen: not reported in source

    BL/VL3 murine T-cell lymphoma cell line
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated · 5-30 minAs given in this study (mouse).

    Source sentences

    Summary
    Short-term (5-30 min) exposures of BL/VL3 cells to VIP or isoproterenol induced both homologous and heterologous desensitization.
    1 context sentence
    Summary · context
    Functional vasoactive intestinal peptide (VIP)/helodermin receptors and beta 2-adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T-cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal).
  2. 02LabIn vitro (cells)Mechanism

    In BL/VL3 cells, the potency of VIP to desensitize was similar to its potency to occupy receptors and activate adenylate cyclase.

    In plain wordsIn mouse lymphoma cells, how strongly VIP desensitized the cells matched how strongly it bound receptors and switched on adenylate cyclase.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicablePotency of VIP to desensitize versus receptor occupancy and adenylate cyclase activation
    Study

    mousen: not reported in source

    BL/VL3 murine T-cell lymphoma cell line
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The potency of VIP and isoproterenol to desensitize was similar to their potency to occupy receptors and activate adenylate cyclase.
    1 context sentence
    Summary · context
    Functional vasoactive intestinal peptide (VIP)/helodermin receptors and beta 2-adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T-cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal).
  3. 03LabIn vitro (cells)Mechanism

    In BL/VL3 cells, long-term (16-h) exposure to VIP induced homologous down regulation only.

    In plain wordsIn mouse lymphoma cells, 16 hours of VIP lowered the response to VIP itself but not to other signals.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseDown regulation after long-term VIP exposure
    Study

    mousen: not reported in source

    BL/VL3 murine T-cell lymphoma cell line
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated · 16 hoursAs given in this study (mouse).

    Source sentences

    Summary
    Long-term (16-h) exposure of BL/VL3 cells to VIP induced homologous down regulation only, whereas isoproterenol induced both homologous and heterologous down regulation.
    1 context sentence
    Summary · context
    Functional vasoactive intestinal peptide (VIP)/helodermin receptors and beta 2-adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T-cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal).
  4. 04LabIn vitro (cells)Mechanism

    In BL/VL3 cells, the potency of VIP and related peptides to decrease homologous responses was comparable to their potency for receptor occupancy and adenylate cyclase activation.

    In plain wordsIn mouse lymphoma cells, how strongly VIP and related peptides lowered the response matched how strongly they bound receptors and switched on adenylate cyclase.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicablePotency of VIP to decrease homologous responses versus receptor occupancy
    Study

    mousen: not reported in source

    BL/VL3 murine T-cell lymphoma cell line
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated · 16 hoursAs given in this study (mouse).

    Source sentences

    Summary
    The potency of VIP, peptide histidine isoleucinamide, helodermin, helospectin, and [D-Phe2]VIP on the one hand, and of isoproterenol on the other hand, to decrease homologous responses was comparable to their potency for receptor occupancy and adenylate cyclase activation.
    1 context sentence
    Summary · context
    Functional vasoactive intestinal peptide (VIP)/helodermin receptors and beta 2-adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T-cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.