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Study · In vitro (cells) · mouse · 1989

3 results

Properties of vasoactive-intestinal-peptide receptors and beta-adrenoceptors in the murine radiation leukemia-virus-induced lymphoma cell line BL/VL3.

Abello J, Damien C, De Neef P, Tastenoy M, Hooghe R, Robberecht P, Christophe J

European journal of biochemistry1 Aug 1989Cited by 15 (Europe PMC)

PMID2547606 (opens in a new tab)DOI10.1111/j.1432-1033.1989.tb14922.x (opens in a new tab)PepBankPUB-02547606
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In membranes from the murine T-cell lymphoma line BL/VL3, VIP/helodermin receptors were functional and activated adenylate cyclase.

    In plain wordsIn cells from a mouse lymphoma line, VIP acted on working receptors that switched on the enzyme adenylate cyclase.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP receptor coupling to adenylate cyclase
    Study

    mousen: not reported in source

    BL/VL3 murine T-cell lymphoma cell line membranes
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Based on radioligand binding and adenylate cyclase activation, functional receptors to vasoactive intestinal peptide(VIP)/helodermin, were shown to coexist with beta 2-adrenoceptors and prostaglandin receptors in membranes from a cultured cloned BL/VL3 cell line of murine T-cell lymphoma induced by…
  2. 02LabIn vitro (cells)Activity measurement

    In BL/VL3 membranes, helodermin was more potent than VIP, and VIP was more potent than peptide histidine isoleucinamide, at stimulating adenylate cyclase.

    In plain wordsIn cells from a mouse lymphoma line, VIP stimulated adenylate cyclase less than helodermin but more than peptide histidine isoleucinamide.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicablePotency to stimulate adenylate cyclase
    Study

    mousen: not reported in source

    BL/VL3 murine T-cell lymphoma cell line membranes
    Comparator
    helodermin; peptide histidine isoleucinamide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The relative potency of VIP-related peptides to stimulate adenylate cyclase activity was: helodermin greater than VIP greater than peptide histidine isoleucinamide.
    1 context sentence
    Summary · context
    Based on radioligand binding and adenylate cyclase activation, functional receptors to vasoactive intestinal peptide(VIP)/helodermin, were shown to coexist with beta 2-adrenoceptors and prostaglandin receptors in membranes from a cultured cloned BL/VL3 cell line of murine T-cell lymphoma induced by…
  3. 03LabIn vitro (cells)Activity measurement

    In BL/VL3 membranes, VIP was the most potent of VIP and five analogs at inhibiting 125I-iodo-VIP binding and at stimulating adenylate cyclase.

    In plain wordsIn cells from a mouse lymphoma line, VIP was stronger than all five tested VIP analogs at binding to receptors and switching on adenylate cyclase.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicablePotency of VIP and analogs: binding inhibition and adenylate cyclase stimulation
    Study

    mousen: not reported in source

    BL/VL3 murine T-cell lymphoma cell line membranes
    Comparator
    five VIP analogs
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Five VIP analogs inhibited 125I-iodo-VIP binding and stimulated adenylate cyclase activity, their decreasing order of potency being: VIP greater than [D-Asp3]VIP greater than [D-Ser2]VIP greater than [D-Ala4]VIP = [D-His1]VIP = [D-Phe2]VIP.
    1 context sentence
    Summary · context
    Based on radioligand binding and adenylate cyclase activation, functional receptors to vasoactive intestinal peptide(VIP)/helodermin, were shown to coexist with beta 2-adrenoceptors and prostaglandin receptors in membranes from a cultured cloned BL/VL3 cell line of murine T-cell lymphoma induced by…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

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