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Study · Non-randomized trial · n = 17 · 1989

9 results

Effect of a new synthetic hexapeptide to selectively stimulate growth hormone release in healthy human subjects.

Ilson BE, Jorkasky DK, Curnow RT, Stote RM

The Journal of clinical endocrinology and metabolism1 Jul 1989Cited by 46 (Europe PMC)

PMID2543692 (opens in a new tab)DOI10.1210/jcem-69-1-212 (opens in a new tab)PepBankPUB-02543692
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

  1. 01HumanNon-randomized trialSafety outcome

    GHRP was safe and well tolerated in all normal men studied.

    In plain wordsThe study reported that all men tolerated GHRP well.

    Peptide
    GHRP-6
    Outcome
    Not applicableTolerability
    Study

    n = 17

    Outcome group
    Adverse events · Whole body
    Studied dose
    0.05 to 2.5 micrograms/kg · intravenous infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    GHRP was safe and well-tolerated in all men.
    2 context sentences
    Summary · context
    GHRP was administered to 17 normal men at doses of from 0.05 to 2.5 micrograms/kg as a 30 min intravenous infusion.
    Summary · context
    Eight of the men were infused with saline as a control.
  2. 02HumanNon-randomized trialEfficacy outcome

    In normal men, GHRP at 0.25 microgram/kg increased peak serum GH versus saline.

    In plain wordsIn normal men, GHRP at this dose increased peak growth hormone compared with saline.

    Peptide
    GHRP-6
    Outcome
    IncreasePeak serum GH at 0.25 microgram/kg
    Study

    n = 4

    Comparator
    saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.25 microgram/kg · intravenous infusion · 30 minAs given in this study (human).

    Measurements

    Mean peak serum GH
    17.8 micrograms/L
    0.25 microgram/kg
    SE
    6.1 micrograms/L
    0.25 microgram/kg

    Source sentences

    Summary
    The mean peak serum GH concentrations (+/- SE) in response to GHRP infusion were 17.8 +/- 6.1 micrograms/L at a dose of 0.25 microgram/kg (n = 4, p = .03 vs saline),
    2 context sentences
    Summary · context
    GHRP was administered to 17 normal men at doses of from 0.05 to 2.5 micrograms/kg as a 30 min intravenous infusion.
    Summary · context
    Eight of the men were infused with saline as a control.
  3. 03HumanNon-randomized trialEfficacy outcome

    In normal men, GHRP at 0.5 microgram/kg increased peak serum GH versus saline.

    In plain wordsIn normal men, GHRP at this dose increased peak growth hormone compared with saline.

    Peptide
    GHRP-6
    Outcome
    IncreasePeak serum GH at 0.5 microgram/kg
    Study

    n = 4

    Comparator
    saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.5 microgram/kg · intravenous infusion · 30 minAs given in this study (human).

    Measurements

    Mean peak serum GH
    38.3 micrograms/L
    0.5 microgram/kg
    SE
    9.2 micrograms/L
    0.5 microgram/kg

    Source sentences

    Summary
    38.3 +/- 9.2 micrograms/L at 0.5 microgram/kg (n = 4, p = .04 vs saline)
    2 context sentences
    Summary · context
    GHRP was administered to 17 normal men at doses of from 0.05 to 2.5 micrograms/kg as a 30 min intravenous infusion.
    Summary · context
    Eight of the men were infused with saline as a control.
  4. 04HumanNon-randomized trialEfficacy outcome

    In normal men, GHRP at 1.0 microgram/kg increased peak serum GH versus saline.

    In plain wordsIn normal men, GHRP at this dose increased peak growth hormone compared with saline.

    Peptide
    GHRP-6
    Outcome
    IncreasePeak serum GH at 1.0 microgram/kg
    Study

    n = 4

    Comparator
    saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.0 microgram/kg · intravenous infusion · 30 minAs given in this study (human).

    Measurements

    Mean peak serum GH
    63 micrograms/L
    1.0 microgram/kg
    SE
    5.4 micrograms/L
    1.0 microgram/kg

    Source sentences

    Summary
    63.0 +/- 5.4 micrograms/L at 1.0 microgram/kg (n = 4, p = .002 vs saline).
    2 context sentences
    Summary · context
    GHRP was administered to 17 normal men at doses of from 0.05 to 2.5 micrograms/kg as a 30 min intravenous infusion.
    Summary · context
    Eight of the men were infused with saline as a control.
  5. 05HumanNon-randomized trialEfficacy outcome

    In normal men, GHRP increased serum GH during infusion, with a peak at 45 min and baseline values by 210 min.

    In plain wordsIn normal men, GHRP increased blood growth hormone during infusion, then levels returned to baseline.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH response time course
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.25 microgram/kg and above · intravenous infusion · 30 minAs given in this study (human).

    Measurements

    Time to peak serum GH
    45 min
    GHRP infusion
    Time to return to baseline serum GH
    ≤ 210 min
    GHRP infusion

    Source sentences

    Summary
    Serum GH increased consistently at doses of 0.25 microgram/kg and above during the infusion of the peptide, peaked at 45 min and then decreased to baseline values by 210 min.
    2 context sentences
    Summary · context
    GHRP was administered to 17 normal men at doses of from 0.05 to 2.5 micrograms/kg as a 30 min intravenous infusion.
    Summary · context
    Eight of the men were infused with saline as a control.
  6. 06HumanNon-randomized trialEfficacy outcome

    In normal men, GHRP did not affect serum LH.

    In plain wordsIn normal men, GHRP did not change blood LH levels.

    Peptide
    GHRP-6
    Outcome
    No significant changeSerum LH
    Study

    n: not reported in source

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    0.05 to 2.5 micrograms/kg · intravenous infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    Serum LH, FSH, TSH and ACTH were unaffected by GHRP administration.
    2 context sentences
    Summary · context
    GHRP was administered to 17 normal men at doses of from 0.05 to 2.5 micrograms/kg as a 30 min intravenous infusion.
    Summary · context
    Eight of the men were infused with saline as a control.
  7. 07HumanNon-randomized trialEfficacy outcome

    In normal men, GHRP did not affect serum FSH.

    In plain wordsIn normal men, GHRP did not change blood FSH levels.

    Peptide
    GHRP-6
    Outcome
    No significant changeSerum FSH
    Study

    n: not reported in source

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    0.05 to 2.5 micrograms/kg · intravenous infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    Serum LH, FSH, TSH and ACTH were unaffected by GHRP administration.
    2 context sentences
    Summary · context
    GHRP was administered to 17 normal men at doses of from 0.05 to 2.5 micrograms/kg as a 30 min intravenous infusion.
    Summary · context
    Eight of the men were infused with saline as a control.
  8. 08HumanNon-randomized trialEfficacy outcome

    In normal men, GHRP did not affect serum TSH.

    In plain wordsIn normal men, GHRP did not change blood TSH levels.

    Peptide
    GHRP-6
    Outcome
    No significant changeSerum TSH
    Study

    n: not reported in source

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    0.05 to 2.5 micrograms/kg · intravenous infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    Serum LH, FSH, TSH and ACTH were unaffected by GHRP administration.
    2 context sentences
    Summary · context
    GHRP was administered to 17 normal men at doses of from 0.05 to 2.5 micrograms/kg as a 30 min intravenous infusion.
    Summary · context
    Eight of the men were infused with saline as a control.
  9. 09HumanNon-randomized trialEfficacy outcome

    In normal men, GHRP did not affect serum ACTH.

    In plain wordsIn normal men, GHRP did not change blood ACTH levels.

    Peptide
    GHRP-6
    Outcome
    No significant changeSerum ACTH
    Study

    n: not reported in source

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    0.05 to 2.5 micrograms/kg · intravenous infusion · 30 minAs given in this study (human).

    Source sentences

    Summary
    Serum LH, FSH, TSH and ACTH were unaffected by GHRP administration.
    2 context sentences
    Summary · context
    GHRP was administered to 17 normal men at doses of from 0.05 to 2.5 micrograms/kg as a 30 min intravenous infusion.
    Summary · context
    Eight of the men were infused with saline as a control.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:59 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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