Appearance and transient expression of oxytocin receptors in fetal, infant, and peripubertal rat brain studied by autoradiography and electrophysiology.

Tribollet E, Charpak S, Schmidt A, Dubois-Dauphin M, Dreifuss JJ

The Journal of neuroscience : the official journal of the Society for Neuroscience1 May 1989Cited by 166 (Europe PMC)

PMID2542479PMCIDPMC6569831DOI10.1523/jneurosci.09-05-01764.1989PepBankPUB-02542479

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study9

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In neonatal rat brainstem slices, oxytocin and a selective oxytocin agonist reversibly increased the firing rate of dorsal motor nucleus of the vagus neurons in a concentration-dependent manner.
In plain wordsIn slices of newborn rat brain, oxytocin made vagal nerve cells fire faster, and more oxytocin gave a larger effect.
Peptide
Oxytocin
Outcome
IncreaseFiring rate of vagal neurons in neonatal rat slices
Study
ratn: not reported in source
Brainstem slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
OT and a selective OT agonist reversibly increased the firing rate of these neurons in a concentration-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
OT receptors were labeled using a monoiodinated OT antagonist in tissue sections from animals aged between embryonic day 12 (E12) and postnatal day 90 (PN90); the response of ongoing spike activity to the addition of OT was assessed in neurons located in the dorsal motor nucleus of the vagus nerve of the neonate.
Report a problemFND-0254247908
02LabEx vivo tissueMechanism
In neonatal rat brainstem slices, the neuronal response to oxytocin was similar to that reported previously in adults.
In plain wordsIn slices of newborn rat brain, nerve cells responded to oxytocin much as adult cells are known to respond.
Peptide
Oxytocin
Outcome
No significant changeNeuronal responsiveness compared with adult
Study
ratn: not reported in source
Brainstem slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The neuronal responsiveness was similar to that reported previously in the adult.
1 context sentence(design, population, supporting numbers)
Summary · context
OT receptors were labeled using a monoiodinated OT antagonist in tissue sections from animals aged between embryonic day 12 (E12) and postnatal day 90 (PN90); the response of ongoing spike activity to the addition of OT was assessed in neurons located in the dorsal motor nucleus of the vagus nerve of the neonate.
Report a problemFND-0254247909

Studies that did not test the peptide alone7

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

03LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In the developing rat brain, specific oxytocin receptor binding was first detected at embryonic day 14 in a region that became the dorsal motor nucleus of the vagus nerve.
In plain wordsIn rat brain tissue, oxytocin receptors first appeared at embryonic day 14.
Peptide
Oxytocin
Outcome
IncreaseOnset of oxytocin receptor binding in the fetal rat brain
Study
ratn: not reported in source
Brain tissue sections
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Specific binding was detected first at E14 in a region that later differentiated into the dorsal motor nucleus of the vagus nerve.
1 context sentence(design, population, supporting numbers)
Summary · context
OT receptors were labeled using a monoiodinated OT antagonist in tissue sections from animals aged between embryonic day 12 (E12) and postnatal day 90 (PN90); the response of ongoing spike activity to the addition of OT was assessed in neurons located in the dorsal motor nucleus of the vagus nerve of the neonate.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0254247901
04LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In the rat brain, many other regions were progressively labelled for oxytocin receptors between embryonic day 20 and postnatal day 5.
In plain wordsIn rat brain tissue, oxytocin receptors appeared in many more brain regions between late fetal life and the first days after birth.
Peptide
Oxytocin
Outcome
IncreaseProgressive labelling of brain regions between E20 and PN5
Study
ratn: not reported in source
Brain tissue sections
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Many other regions were progressively labeled between E20 and PN5.
1 context sentence(design, population, supporting numbers)
Summary · context
OT receptors were labeled using a monoiodinated OT antagonist in tissue sections from animals aged between embryonic day 12 (E12) and postnatal day 90 (PN90); the response of ongoing spike activity to the addition of OT was assessed in neurons located in the dorsal motor nucleus of the vagus nerve of the neonate.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0254247902
05LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In the rat brain, the distribution of oxytocin binding sites stayed essentially unchanged from postnatal day 5 to 16 but differed from the adult pattern.
In plain wordsIn rat brain tissue, the pattern of oxytocin receptors stayed the same for the first weeks of life and differed from the mature pattern.
Peptide
Oxytocin
Outcome
No significant changeBinding site distribution from PN5 to PN16
Study
ratn: not reported in source
Brain tissue sections
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
From PN5 to PN16, the distribution of binding sites remained essentially unchanged but differed markedly from that characteristic of the adult.
1 context sentence(design, population, supporting numbers)
Summary · context
OT receptors were labeled using a monoiodinated OT antagonist in tissue sections from animals aged between embryonic day 12 (E12) and postnatal day 90 (PN90); the response of ongoing spike activity to the addition of OT was assessed in neurons located in the dorsal motor nucleus of the vagus nerve of the neonate.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0254247903
06LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In the rat brain, the switch from the infant to the adult pattern of oxytocin binding happened in two stages, at preweaning and after postnatal day 35 at puberty onset.
In plain wordsIn rat brain tissue, oxytocin receptor patterns changed from the infant to the adult pattern in two stages.
Peptide
Oxytocin
Outcome
MixedChange from infant to adult binding pattern
Study
ratn: not reported in source
Brain tissue sections
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
The change-over from the "infant pattern" to the "adult pattern" occurred in 2 stages: the first change took place between PN16 and PN22, a time corresponding to the preweaning period; the second change occurred after PN35 and thus coincided with the onset of puberty.
1 context sentence(design, population, supporting numbers)
Summary · context
OT receptors were labeled using a monoiodinated OT antagonist in tissue sections from animals aged between embryonic day 12 (E12) and postnatal day 90 (PN90); the response of ongoing spike activity to the addition of OT was assessed in neurons located in the dorsal motor nucleus of the vagus nerve of the neonate.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0254247904
07LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In the rat brain, oxytocin binding was reduced or disappeared in several areas, particularly the cingulate cortex and dorsal hippocampus, during the first transition period.
In plain wordsIn rat brain tissue, oxytocin receptors were lost from some regions, such as the cingulate cortex, as the rats matured.
Peptide
Oxytocin
Outcome
DecreaseBinding in cingulate cortex and dorsal hippocampus during first transition
Study
ratn: not reported in source
Brain tissue sections
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
During the first transition period, binding was reduced or disappeared in several areas intensely labeled at earlier stages, in particular, in the cingulate cortex and the dorsal hippocampus.
1 context sentence(design, population, supporting numbers)
Summary · context
OT receptors were labeled using a monoiodinated OT antagonist in tissue sections from animals aged between embryonic day 12 (E12) and postnatal day 90 (PN90); the response of ongoing spike activity to the addition of OT was assessed in neurons located in the dorsal motor nucleus of the vagus nerve of the neonate.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0254247905
08LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In the rat brain, oxytocin binding sites appeared in the ventral hippocampus during the first transition period.
In plain wordsIn rat brain tissue, oxytocin receptors appeared in the lower part of the hippocampus as the rats matured.
Peptide
Oxytocin
Outcome
IncreaseBinding in ventral hippocampus during first transition
Study
ratn: not reported in source
Brain tissue sections
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
At the same time, binding sites appeared in the ventral hippocampus.
1 context sentence(design, population, supporting numbers)
Summary · context
OT receptors were labeled using a monoiodinated OT antagonist in tissue sections from animals aged between embryonic day 12 (E12) and postnatal day 90 (PN90); the response of ongoing spike activity to the addition of OT was assessed in neurons located in the dorsal motor nucleus of the vagus nerve of the neonate.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0254247906
09LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In the rat brain at puberty, high densities of oxytocin binding sites appeared in the ventromedial hypothalamic nucleus and the olfactory tubercle.
In plain wordsIn rat brain tissue, oxytocin receptors became dense in two brain regions at puberty.
Peptide
Oxytocin
Outcome
IncreaseBinding in ventromedial hypothalamic nucleus and olfactory tubercle at puberty
Study
ratn: not reported in source
Brain tissue sections
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
At puberty, high densities of OT binding sites appeared in the ventromedial hypothalamic nucleus and the olfactory tubercle.
1 context sentence(design, population, supporting numbers)
Summary · context
OT receptors were labeled using a monoiodinated OT antagonist in tissue sections from animals aged between embryonic day 12 (E12) and postnatal day 90 (PN90); the response of ongoing spike activity to the addition of OT was assessed in neurons located in the dorsal motor nucleus of the vagus nerve of the neonate.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0254247907

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

Subjects

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