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Study · In vitro (cells) · mouse · 1989

3 results

Prostaglandins promote osteoclastlike cell formation by a mechanism involving cyclic adenosine 3',5'-monophosphate in mouse bone marrow cell cultures.

Akatsu T, Takahashi N, Debari K, Morita I, Murota S, Nagata N, Takatani O, Suda T

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Feb 1989Cited by 140 (Europe PMC)

PMID2541600 (opens in a new tab)DOI10.1002/jbmr.5650040106 (opens in a new tab)PepBankPUB-02541600
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In mouse bone marrow cultures, salmon calcitonin greatly inhibited PGE2-induced osteoclast-like cell formation.

    In plain wordsIn mouse cells, salmon calcitonin inhibited PGE2-induced osteoclast-like cell formation compared with PGE2 alone.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreasePGE2-induced osteoclast-like cell formation
    Study

    mousen: not reported in source

    Mouse bone marrow cell cultures
    Comparator
    PGE2 without salmon calcitonin
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, isobutylmethylxanthine (IBMX), a potent inhibitor of phosphodiesterase, potentiated the OC-like cell formation induced by PGE2, whereas salmon calcitonin greatly inhibited it.
    2 context sentences
    Summary · context
    We have developed a mouse bone marrow culture system in which multinucleated osteoclast (OC)-like cells are formed within 8 days.
    Summary · context
    Using this culture system, we examined the effect of prostaglandins (PGs), potent bone-resorbing agents, on OC-like cell formation.
  2. 02LabIn vitro (cells)Mechanism

    In mouse bone marrow cultures treated with PGE2, calcitonin induced cAMP production.

    In plain wordsIn mouse cells treated with PGE2, calcitonin increased cAMP production.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreasecAMP production with PGE2
    Study

    mousen: not reported in source

    Mouse bone marrow cell cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Calcitonin induced cAMP production in cultures treated with PGE2, but not in cultures with vehicle.
    2 context sentences
    Summary · context
    We have developed a mouse bone marrow culture system in which multinucleated osteoclast (OC)-like cells are formed within 8 days.
    Summary · context
    Using this culture system, we examined the effect of prostaglandins (PGs), potent bone-resorbing agents, on OC-like cell formation.
  3. 03LabIn vitro (cells)Mechanism

    In mouse bone marrow cultures treated with vehicle, calcitonin did not induce cAMP production.

    In plain wordsIn mouse cells treated with vehicle, calcitonin did not increase cAMP production.

    Peptide
    Calcitonin-salmon
    Outcome
    No significant changecAMP production with vehicle
    Study

    mousen: not reported in source

    Mouse bone marrow cell cultures
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Calcitonin induced cAMP production in cultures treated with PGE2, but not in cultures with vehicle.
    2 context sentences
    Summary · context
    We have developed a mouse bone marrow culture system in which multinucleated osteoclast (OC)-like cells are formed within 8 days.
    Summary · context
    Using this culture system, we examined the effect of prostaglandins (PGs), potent bone-resorbing agents, on OC-like cell formation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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