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Study · Animal study (in vivo) · rat · 1989

5 results

Dermorphin inhibits micturition reflex in rats at a central site of action.

Maggi CA, Giuliani S, Meli A

Journal of the autonomic nervous system1 Feb 1989Cited by 10 (Europe PMC)

PMID2540230 (opens in a new tab)DOI10.1016/0165-1838(89)90102-1 (opens in a new tab)PepBankPUB-02540230
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In urethane-anesthetized rats, intrathecal dermorphin dose-dependently inhibited reflex micturition until voiding stopped.

    In plain wordsIn rats under anesthesia, intrathecal dermorphin inhibited reflex urination until voiding stopped.

    Peptide
    Dermorphin
    Outcome
    DecreaseReflex micturition inhibition
    Study

    ratn: not reported in source

    Urethane-anesthetized rats
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    0.8-80 ng · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Intrathecal dermorphin (0.8-80 ng) or [D-Ala2, D-Leu5]-enkephalin (DADLE, 5.7-171 ng) produced a dose-related marked inhibition of reflex micturition in urethane-anesthetized rats until voiding was suppressed and overflow incontinence ensued.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In urethane-anesthetized rats, intrathecal dermorphin caused overflow incontinence after voiding suppression.

    In plain wordsIn rats under anesthesia, intrathecal dermorphin caused overflow incontinence after voiding stopped.

    Peptide
    Dermorphin
    Outcome
    IncreaseOverflow incontinence
    Study

    ratn: not reported in source

    Urethane-anesthetized rats
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    0.8-80 ng · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Intrathecal dermorphin (0.8-80 ng) or [D-Ala2, D-Leu5]-enkephalin (DADLE, 5.7-171 ng) produced a dose-related marked inhibition of reflex micturition in urethane-anesthetized rats until voiding was suppressed and overflow incontinence ensued.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intravenous dermorphin had little or no effect on micturition up to 8 micrograms/kg.

    In plain wordsIn rats, intravenous dermorphin had little or no effect on urination.

    Peptide
    Dermorphin
    Outcome
    No significant changeMicturition after intravenous dermorphin
    Study

    ratn: not reported in source

    Urethane-anesthetized rats
    Outcome group
    Urinary continence and bladder function · Kidney and urinary
    Studied dose
    up to 8 micrograms/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Intravenous dermorphin had little or no effect on micturition up to 8 micrograms/kg.

Studies that did not test the peptide alone2

In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Dermorphin.

  1. 04AnimalNot a test of Dermorphin aloneAnimal study (in vivo)Mechanism

    In rats, intravenous naloxone promptly abolished dermorphin-induced micturition inhibition.

    In plain wordsIn rats, intravenous naloxone promptly abolished dermorphin-induced inhibition of urination.

    Peptide
    Dermorphin
    Outcome
    Not applicableNaloxone reversal of micturition inhibition
    Study

    ratn: not reported in source

    Urethane-anesthetized rats
    Outcome group
    Urinary continence and bladder function · Kidney and urinary

    Source sentences

    Summary
    These effects of dermorphin or DADLE were promptly abolished by i.v. naloxone (0.2 mg/kg).
    1 context sentence
    Summary · context
    Intrathecal dermorphin (0.8-80 ng) or [D-Ala2, D-Leu5]-enkephalin (DADLE, 5.7-171 ng) produced a dose-related marked inhibition of reflex micturition in urethane-anesthetized rats until voiding was suppressed and overflow incontinence ensued.

    In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dermorphin.

  2. 05AnimalNot a test of Dermorphin aloneAnimal study (in vivo)Mechanism

    In rats, systemic capsaicin desensitization partially prevented dermorphin-induced micturition inhibition.

    In plain wordsIn rats, capsaicin desensitization partially prevented dermorphin-induced inhibition of urination.

    Peptide
    Dermorphin
    Outcome
    Not applicableCapsaicin sensitivity of micturition inhibition
    Study

    ratn: not reported in source

    Urethane-anesthetized rats
    Outcome group
    Urinary continence and bladder function · Kidney and urinary

    Source sentences

    Summary
    The inhibitory effect of dermorphin but not that of DADLE was partially prevented by systemic capsaicin desensitization (50 mg/kg s.c., 4 days before).
    1 context sentence
    Summary · context
    Intrathecal dermorphin (0.8-80 ng) or [D-Ala2, D-Leu5]-enkephalin (DADLE, 5.7-171 ng) produced a dose-related marked inhibition of reflex micturition in urethane-anesthetized rats until voiding was suppressed and overflow incontinence ensued.

    In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dermorphin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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