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Study · Not a test of the peptide alone · 1989

2 results

Insulin-like growth factor (IGF)-binding proteins inhibit the biological activities of IGF-1 and IGF-2 but not des-(1-3)-IGF-1.

Ross M, Francis GL, Szabo L, Wallace JC, Ballard FJ

The Biochemical journal1 Feb 1989Cited by 90 (Europe PMC)

PMID2539101 (opens in a new tab)PMCIDPMC1138350 (opens in a new tab)DOI10.1042/bj2580267 (opens in a new tab)PepBankPUB-02539101
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 01LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement

    In chick embryo fibroblasts, MDBK-cell binding protein did not influence the biological activities of des-(1-3)-IGF-1.

    In plain wordsIn cells, the binding protein did not change des-(1-3)-IGF-1 biological activities.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeBiological activity with binding protein
    Study

    chickenn: not reported in source

    Chick embryo fibroblasts
    Comparator
    Without MDBK-cell binding protein
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The binding protein did not influence the biological activities of des-(1-3)-IGF-1, while effects on IGF-1 were intermediate.
    1 context sentence
    Summary · context
    (2) A binding protein purified from bovine kidney (MDBK) cells potently inhibited the ability of IGF-2 to stimulate DNA synthesis or protein accumulation as well as to reduce rates of protein breakdown in chick embryo fibroblasts.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  2. 02LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism

    In cultured-cell assays, des-(1-3)-IGF-1 enhanced potency correlated with its lack of binding to purified or cell-released binding proteins.

    In plain wordsIn lab tests, stronger des-(1-3)-IGF-1 activity was linked to its lack of binding to binding proteins.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Not applicableBinding protein association and potency
    Study

    n: not reported in source

    Cultured-cell and purified binding-protein assays
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    (4) The biological potencies of IGF-1, IGF-2 and des-(1-3)-IGF-1 correlate inversely with their binding to proteins released into the medium by cells, so that the enhanced potency of des-(1-3)-IGF-1 is a consequence of it not binding to purified binding proteins or those released by cultured cells.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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